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All Journal Jurnal Mandala Pengabdian Masyarakat Indonesian Journal of Health Sciences Research and Development (IJHSRD)
Purnamasari, Wa Ode Gustiani
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Health Professions Public Health Social Sciences

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IMMUNOMODULATORY POTENTIAL OF ETHANOL EXTRACT OF HENNA LEAF (Lawsonia Inermis L.) AGAINST MACROPHAGE PHAGOCYTOSIS IN MALE MICE (Mus Musculus): EXTRACT OF HENNA LEAF Purnamasari, Wa Ode Gustiani; Mulanna, Fauziah; Yuliastri, Wa Ode; Yuhadi, Asfani
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 7 No. 1 (2025): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol7.Iss1/293

Abstract

Background: One of the herbal plants that can be used as an immunomodulator is henna leaves (Lawsonia inermis L.) that increase the function of the immune system. The purpose of this study was to determine the immunomodulatory potential of henna leaves on macrophage phagocytosis and to determine at what dose the ethanol extract of henna leaves has the potential for macrophage phagocytosis in male mice (Mus musculus). Methods: The type of research used is analytical research using administering ethanol extract of henna leaves on increasing macrophage phagocytosis in male mice (Mus musculus) induced by Staphylococcus aureus, and to determine which dose is more effective in increasing phagocytosis using the phagocytosis test. The analysis method uses the ANOVA Statistical Test and the LSD Post Hoc Test. Results: The study showed that the ethanol extract of henna leaves has an immunomodulatory effect based on the results of the One Way ANOVA statistical test and post hoc test (p-value <0.05). The dose of ethanol extract of henna leaves that has immunomodulatory potential is a dose of 100 mg/kgBW (34.33%), a dose of 200 mg/kgBW (46%), a dose of 300 mg/kgBW (74.66%) and a dose of 400 mg/kgBW (75.33%). Conclusion: The study conclude that Ethanol extract of henna leaves has mmunomodulatory potential by increasing macrophage phagocytosis activity in male mice. Ethanol extract of henna leaves which is effective as an immunomodulator is 400 mg/kgBW which has a higher percentage of macrophage phagocytosis activity value compared to other dose variations, and is approximately the same as the positive control this is due to the number of phagocytic cells that actively carry out phagocytosis and is expressed as a percentage.
Edukasi Dan Pemeriksaan Kesehatan (Kimia Darah & Hipertensi) Untuk Meningkatkan Derajat Kesehatan Pada Masyarakat Desa Walelei Kecamatan Barangka Kabupaten Muna Barat Purnama, Titi; Purnamasari, Wa Ode Gustiani; Yuhadi, Asfani; Sanatang, Sanatang
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 1 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i1.559

Abstract

Edukasi dan Pemeriksaan kesehatan yang meliputi pemeriksaan kimia darah seperti, glukosa darah, kolesterol, asam urat merupakan salah satu pemeriksaan penunjang utama untuk medeteksi adanya suatu gejala penyakit yang di alami oleh warga desa. Tujuan utama dari pemeriksaan-pemeriksaan ini adalah untuk mendeteksi dini adanya penyakit atau kondisi kesehatan yang berpotensi serius, seperti diabetes, gout, atau tekanan darah tinggi, dengan melakukan pemeriksaan rutin, dokter dapat mengidentifikasi masalah kesehatan sebelum berkembang menjadi lebih parah, sehingga memungkinkan intervensi dini yang efektif. Lokasi pengabdian dilaksanakan di Desa Walelei Kecamatan Barangka Kanupaten Muna barat Provinsi Sulawesi Tenggara. Jumlah Responden sebanyak 20 orang yang melakukan pemeriksaan kesehatan. Kesimpulan pada pengabdian ini adalah bahwa Edukasi dan Pemeriksaan kesehatan (Kimia Darah dan Hipertensi) di Desa Walelei Kecamatan Barangka  Kabupaten Muna Barat Provinsi Sulawesi Tenggara merupakan komponen integral dalam manajemen kesehatan komprehensif, terutama bagi populasi berisiko tinggi seperti lansia. Pendekatan terpadu dalam pemeriksaan dan edukasi ini tidak hanya memfasilitasi deteksi dini dan manajemen yang efektif, tetapi juga memberdayakan individu untuk berpartisipasi aktif dalam perawatan kesehatan mereka sendiri serta dapat meningkatkan derajat kesehatan.
Co-Authors Mulanna, Fauziah Purnama, Titi Sanatang Yuhadi, Asfani Yuliastri, Wa Ode