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All Journal Jurnal Kedokteran Universitas Palangka Raya Jurnal Ekonomi Syariah Indonesia
Kartika, Tasya
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Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Immunology & microbiology Medicine & Pharmacology Public Health

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Ketidakseimbangan Th17 dan Treg Pada Pasien PCOS Dengan Resistensi Insulin: Tinjauan Literatur Terhadap Potensi Suntikan Terapi Franciska, Shelly; Hestiantro, Andon; Kartika, Tasya
Jurnal Kedokteran Universitas Palangka Raya Vol 13 No 1 (2025): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v13i1.17456

Abstract

Polycystic ovary syndrome or polycystic ovary syndrome (PCOS) is a metabolic-endocrine disorder characterized by oligoovulation/anovulation, hyperandrogenism, and polycystic ovaries on ultrasound. Globally, PCOS affects 6-21% of women of reproductive age and about 95% of them experience insulin resistance. In Indonesia, the prevalence of PCOS reaches 5-10% where 72.04% are associated with infertility and insulin resistance. Immunoendocrinology notes that the immune response plays a role in the development of PCOS. Several mechanisms cause chronic inflammation caused by insulin resistance, hyperandrogenemia, and dyslipidemia. Research shows a correlation between pro-inflammatory cytokines, especially T-helper 17 (Th17) cells and T-regulatory cells (Treg), in PCOS and insulin resistance. Th17 cells increase inflammation, while Tregs play the opposite role, with their differentiation modulated by interleukin-6 (IL-6) and Transforming Growth Factor-β (TGF-β). Th17/Treg balance can be regulated by targeting IL-6. This study compared Th17 and Treg levels in PCOS patients with and without insulin resistance using IL-17 and IL-10 markers. Th17 was higher and Treg was lower in PCOS with insulin resistance, resulting in a higher Th17/Treg ratio compared to patients without insulin resistance. The results of this study provide an opportunity to target the Th17/Treg axis in new therapies to break the cycle of PCOS and insulin resistance and reduce complications
PENERAPAN PRINSIP KUALITAS DAN ETIKA ISLAM DALAM MENCAPAI MUTU HASIL PRODUKSI Wahyudin, Ahmad; Mulyana, Dede; Nuralimin, Hardik; Diki Zatnika, Satria; Kartika, Tasya
Jurnal Ekonomi Syariah Indonesia (JESI) Vol. 4 No. 1 (2025): Maret
Publisher : STEI Al-Amar Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57171/jesi.v4i1.152

Abstract

PT. Piranti Teknik Indonesia merupakan salah satu perusahaan manufacturing yang bergerak pada bidang otomotif, khususnya pada pembuatan wiring harnes atau kabel body motor. saat ini perusahaan tersebut sudah memberikan jasa kepada beberapa customer baik dari dalam maupun luar negeri, contohnya yaitu Astra Honda Motor (AHM), Kawasaki, Suzuki, Asahi Denso, Toyo Denso, dan lain-lain. Penelitian ini bertujuan untuk mengevaluasi penerapan prinsip kualitas jika dijalankan dan dipatuhi secara konsisten dalam mempertahankan kelancaran proses produksi dengan mengacu pada etika Islam yang berlaku. Penelitian ini menggunakan sistem penelitian kualitatif, teknik dalam pengumpulan data yang dilakukan melalui proses wawancara, observasi dan data dokumentasi berupa Standar Operasional Prosedur yaitu SOP-QAS-009. Hasil penelitian menunjukan bahwa penerapan prinsip-prinsip etika islam terutama dalam hal kejujuran yang memiliki peran penting dalam menciptakan lingkungan kerja yang mendukung integritas dan kualitas produk.
Co-Authors Ahmad Wahyudin Dede Mulyana, Dede Diki Zatnika, Satria Franciska, Shelly Hestiantro, Andon Nuralimin, Hardik