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All Journal Biopendix: Jurnal Biologi, Pendidikan dan Terapan INVENTION: Journal Research and Education Studies
Situmeang, Juwita Cristina
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Biochemistry, Genetics & Molecular Biology Education Other

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Mekanisme Neuroplastisitas dalam Pembelajaran dan Pemulihan Fungsi Setelah Cedera Sistem Saraf Pusat: Tinjauan Literatur Komprehensif Purba, Greace Enita; Hutapea, Helen Veronita; Situmeang, Juwita Cristina; Nababan, Novia Christy; Saragi, Shela Estica; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2491

Abstract

Central nervous system (CNS) injuries such as stroke are a leading cause of global disability (51 million DALYs), with a prevalence in Indonesia reaching 10.9% (GBD, 2019; Riskesdas, 2018). Neuroplasticity through BDNF-dependent synaptic plasticity mechanisms (Kowianski et al., 2018) and tDCS-mediated cortical reorganization (Lefaucheur et al., 2022) offers rehabilitation solutions, but their implementation faces challenges due to genetic variability (BDNF Val66Met) and technological access disparities (Siregar et al., 2023). This article aims to: Analyze BDNF-tDCS interactions at molecular and clinical levels.Evaluate the effectiveness of tDCS based on recent evidence (2019–2024).Formulate low-cost implementation strategies for Indonesia.The methodology involves a systematic PRISMA review of 45 studies from PubMed, Scopus, and ScienceDirect. The analysis includes:  Meta-analysis of tDCS effects on motor recovery (RevMan 5.4). Policy analysis using the WHO framework for essential health technologies. Key findings indicate: BDNF levels >35 ng/mL enhance motor recovery by 2.3x (95% CI: 1.8–3.1; p<0.001). tDCS significantly improves motor function (23.5%, p<0.01), but only in BDNF Val/Val genotypes.Implementation cost: Portable tDCS protocols (Rp500,000/unit) are 90% cheaper than TMS.Integration of BDNF genotype screening, standardized tDCS protocols, and policy advocacy can optimize CNS rehabilitation in Indonesia. This study provides the first evidence-based guide combining neuroscience and health policy.
Mekanisme Neuroplastisitas dalam Pembelajaran dan Pemulihan Fungsi Setelah Cedera Sistem Saraf Pusat: Tinjauan Literatur Komprehensif Purba, Greace Enita; Hutapea, Helen Veronita; Situmeang, Juwita Cristina; Nababan, Novia Christy; Saragi, Shela Estica; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2491

Abstract

Central nervous system (CNS) injuries such as stroke are a leading cause of global disability (51 million DALYs), with a prevalence in Indonesia reaching 10.9% (GBD, 2019; Riskesdas, 2018). Neuroplasticity through BDNF-dependent synaptic plasticity mechanisms (Kowianski et al., 2018) and tDCS-mediated cortical reorganization (Lefaucheur et al., 2022) offers rehabilitation solutions, but their implementation faces challenges due to genetic variability (BDNF Val66Met) and technological access disparities (Siregar et al., 2023). This article aims to: Analyze BDNF-tDCS interactions at molecular and clinical levels.Evaluate the effectiveness of tDCS based on recent evidence (2019–2024).Formulate low-cost implementation strategies for Indonesia.The methodology involves a systematic PRISMA review of 45 studies from PubMed, Scopus, and ScienceDirect. The analysis includes:  Meta-analysis of tDCS effects on motor recovery (RevMan 5.4). Policy analysis using the WHO framework for essential health technologies. Key findings indicate: BDNF levels >35 ng/mL enhance motor recovery by 2.3x (95% CI: 1.8–3.1; p<0.001). tDCS significantly improves motor function (23.5%, p<0.01), but only in BDNF Val/Val genotypes.Implementation cost: Portable tDCS protocols (Rp500,000/unit) are 90% cheaper than TMS.Integration of BDNF genotype screening, standardized tDCS protocols, and policy advocacy can optimize CNS rehabilitation in Indonesia. This study provides the first evidence-based guide combining neuroscience and health policy.
Analysis of Science Learning Implementation in the Implementation of the Independent Curriculum at the Junior High School Level Situmeang, Juwita Cristina; Nababan, Novia; Simanjuntak, Mariati
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 13 No 1 (2026): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol13issue1page21-26

Abstract

This study aims to analyze the implementation of science education in the Merdeka Curriculum at the junior high school level. The research method used is descriptive qualitative, with data collected through observation, interviews, and documentation. This study examines the learning tools, learning resources and media, and strategies applied by teachers in learning activities. The results of the study show that the implementation of science learning in the Merdeka Curriculum still encounters various obstacles, such as learning that tends to be teacher-centered, lack of utilization of laboratories and technology-based media, and teaching tools that are not fully in line with the principles of differentiation and project-based learning. Nevertheless, teachers try to adapt to the curriculum requirements by using Merdeka Curriculum textbooks and conducting simple discussions in class. This study concludes that the implementation of the Merdeka Curriculum in science learning requires support in the form of improving teacher skills, providing technology-based learning media, and developing innovative and contextual teaching tools. In this way, science learning can be more dynamic, meaningful, and in line with the characteristics of learning in the 21st century
Co-Authors Hutapea, Helen Veronita Melva Silitonga Nababan, Novia Nababan, Novia Christy Purba, Greace Enita Saragi, Shela Estica Simanjuntak, Mariati