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All Journal Science Midwifery Medical Sains : Jurnal Ilmiah Kefarmasian
Solihah, Nurlaella
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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ARTICLE REVIEW: EFFECTIVENESS OF COMBINATION OF PLANT EXTRACTS AS ALTERNATIVE HYPERTENSION THERAPY Almasih, Royan; Hasimun, Patonah; Solihah, Nurlaella
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1704

Abstract

Hypertension is a global health problem requiring effective and safe management. Conventional therapies often face challenges, such as drug resistance, side effects, and patient non-compliance, increasing the need for alternative therapies. This article aims to review the effectiveness of plant extract combinations as antihypertensive therapies. This study used a literature review approach to studies published in the last 10 years, focusing on the mechanism of action, effectiveness, and synergistic potential of plant combinations. The results showed that combinations such as Anredera cordifolia (ten.) v. Steenis and Sonchus arvensis L. provided a decrease in systolic blood pressure (SBP) by 27.95 mmHg and diastolic blood pressure (DBP) by 33.89 mmHg, approaching the effectiveness of standard drugs such as valsartan. The main mechanisms include the inhibition of angiotensin-converting enzyme (ACE), vasodilation through the release of nitric oxide (NO), and diuretic effects. The combination of plant extracts shows potential as a safe and effective alternative; however, further clinical trials are needed to strengthen these findings. Keywords: Combination of Plant Extracts, Antihypertensive, Alternative Therapy.
Article review: The role of probiotics in maintaining balance intestinal microbiota on diarrhea infection therapy Solihah, Nurlaella; Mulyani, Yani; Kaniawati, Marita
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2165

Abstract

Diarrhea infections are a significant global health problem, especially in developing countries and can be caused by bacterial, viral or parasitic infections. Antibiotics are often given times ineffective in long-term use and risk disrupting the balance of intestinal microbiota. So that probiotics are needed that come from living microorganisms that provide health benefits if consumed in sufficient quantities. Review This article aims to review the role of probiotics in maintaining the balance of intestinal microbiota and their effectiveness in diarrheal infection therapy. Through literature analysis, several probiotic strains such as Lactobacillus and Bifidobacterium have shown their ability to inhibit the growth of pathogens, such as Escherichia coli and Clostridium difficile, through nutrient competition, production of antimicrobial substances, and immune modulation. This article concludes that probiotics have great potential as an additional therapy that is safe, effective and has minimal side effects in treating diarrheal infections. However, further studies are needed to determine the optimal dose, duration of use, and effectiveness of probiotics in various populations and types of diarrhea.
Co-Authors Almasih, Royan Hasimun, Patonah Marita Kaniawati Yani Mulyani