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All Journal Respiratory Science
Martini, Ni Putu Laksmi Ananda
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Health Professions Medicine & Pharmacology

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Positivity Rates of Histology Results Based on Lesion Size and Bronchus Sign in Lung Cancer Navratilova, Melfia; Aniwidyaningsih, Wahju; Soehardiman, Dicky; Prasenohadi, Prasenohadi; Alatas, Muhamad Fahmi; Elhidsi, Mia; Desiyanti, Ginanjar Arum; Reisa, Tina; Martini, Ni Putu Laksmi Ananda
Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i3.175

Abstract

Background: Lung cancer continues to be a major cause of cancer-related deaths globally. Bronchoscopy serves as a key diagnostic tool, allowing histological sampling through transbronchial biopsy (TBB). The bronchus sign, identified on pre-biopsy CT scans, is associated with improved diagnostic yield in TBB. Method: A retrospective study was conducted between October and December 2023 at Persahabatan Hospital, Jakarta, analyzing 88 patients suspected of lung cancer. Data collected comprised patient demographics, lesion size as determined by CT scans, and the presence or absence of the bronchus sign. Fisher’s exact test was applied for statistical analysis, with a predetermined significance level of P<0.05. Results: Positive histology results were identified in 38 cases (55.07%) for lesions ≥3 cm and 9 cases (47.39%) for <3 cm(P=0.607). In lesions ≥3 cm, the positivity rate was similar between those with the presence (55.81%) and absence (53.85%) of a bronchus sign (P>0.99). In lesions <3 cm, positivity was higher with a bronchus sign (60%) than without (25%) (P=0.55). Conclusion: The bronchus sign appears to increase TBB positivity, especially in peripheral lesions <3 cm. Lesion size also appears to influence TBB yield. However, the findings were not statistically significant, likely due to small sample size and missing CT data.
Dry Pleuroscopy as a Diagnostic Tool for Lung Cancer with Minimal Pleural Effusion Putra, Muhammad Ryan Adi; Aniwidyaningsih, Wahju; Martini, Ni Putu Laksmi Ananda
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.178

Abstract

Dry pleuroscopy is a minimally invasive procedure used to evaluate and manage pleural conditions, particularly in cases of minimal pleural effusion (mini-PE) or dry pleural dissemination (DPD). This procedure involves the induction of artificial pneumothorax to create a workspace, allowing for direct access to the pleura without relying on a significant pleural effusion, unlike wet pleuroscopy. The key advantages of dry pleuroscopy include the elimination of the need for general anesthesia, mechanical ventilation, or specialized operating rooms, thereby reducing the risk of complications and associated costs. With a sensitivity of 94.4% and a specificity of 92.8%, dry pleuroscopy is highly effective for diagnosing lung cancer and pleural metastases in cases of minimal effusion. It also aids in lung cancer staging, minimizing the need for invasive procedures like lobectomy in complex cases. Artificial pneumothorax is a key step in dry pleuroscopy. It can be achieved through blunt dissection, optical trocars, or specialized tools such as the Boutin needle or Veress cannula. Ultrasound (USG) guidance further enhances procedural accuracy and safety by reducing complications. Dry pleuroscopy provides a safe, effective, and cost-efficient diagnostic and therapeutic solution, making it preferable to methods such as video-assisted thoracoscopic surgery (VATS), especially in patients unfit for invasive procedures.
Co-Authors Alatas, Muhamad Fahmi Aniwidyaningsih, Wahju Desiyanti, Ginanjar Arum Elhidsi, Mia Navratilova, Melfia Prasenohadi, Prasenohadi Putra, Muhammad Ryan Adi Reisa, Tina Soehardiman, Dicky