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All Journal Jambura Journal of Chemistry Indonesian Journal of Science and Pharmacy
Rosaldi, Hikmah
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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Simultaneous Solubility Analysis of Paracetamol, Propyphenazone, and Caffeine Using Principal Component and Absorbance Ratio Regression Methods Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.39

Abstract

Medicines can cause changes in the physiology or psychology of an organism when consumed. In general, medicines consist of several mixtures of active ingredients such as paracetamol (PCT), propifenazone (PRO), and caffeine (KAF), which are often found in several types of branded medicines that are claimed to be able to cure or treat. This research aims to obtain a type of solvent that has the smallest photometric error value and can completely dissolve the active ingredient mixture of PCT, PRO, and KAF. In general, organic solvents such as ethanol and methanol are very often used to dissolve compounds that mix with each other, but these solvents cannot always dissolve other active substances. Therefore, researchers carried out an analysis of several types of solvents that could dissolve the three active ingredients. Solvents that can dissolve perfectly without any specification stage must go through a solvent optimization process. The types of solvents that will be tested are methanol, HCl 0.1N, phosphate buffer pH 7.2, and the ratio of phosphate buffer: methanol (DM) (DM 9:1 pH 7.4), (DM 7:3 pH 7.8), (DM 5:5 pH 8.3), (DM 3:7 pH 8.9), and (DM 1:9 pH 9.6). The results of this research show that the solvent that has the smallest photometric error value and can completely dissolve the three active substances is the DM 7:3 pH 7.8 solvent with a total percentage of 0.0846%, which is the smallest value compared to other solvents that have been optimized.
Analisis Kadar Parasetamol dan Kafein Dalam Sediaan Tablet Menggunakan Metode Spektrofotometri Derivatif Zero Crossing Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto
Jambura Journal of Chemistry Vol 7, No 2 (2025): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i2.24392

Abstract

The development of drugs in the form of combination tablets at this time has increased a lot; combining drugs in a tablet preparation can provide an increasing reaction and ability. This makes combining drugs such as Paracetamol and caffeine an effective combination in the pharmaceutical field. Paracetamol is an antipyretic analgesic drug that can be combined with caffeine which can be used in therapy with a combination of these drugs. The objective of this research was to ascertain the concentration of a combination of paracetamol and caffeine in a tablet formulation by employing a zero cross-derivative spectrophotometric method. In this study, solvent optimization was carried out with 17 categories of solvent selection, and acetate: methanol (30:70) was selected using the zero cross-derivative methods with a dA / d plot utilizing the maximum wavelength of paracetamol 258 nm and caffeine 288 nm, because there was an actual wavelength shift in this analysis. To validate the determination of the level of the zero cross-derivative method using the second absorption in the ace solvent (30:70 acetate: methanol). Spectrophotometric analysis of zero crossing derivatives of a mixture of paracetamol and caffeine found that paracetamol levels in tablet A were 95.24 8.47%, in tablet B of 92.86 0%, and in tablet C of 96.5 0%, while the caffeine content was 104.89 0%, 102.09 0%, and 91.6 0%. According to USP 30 NF 25 (2007), it can be concluded that the test results of the composition of paracetamol and caffeine in tablets meet the requirements.
Co-Authors Anny Sartika Daulay Fithri Pulungan, Ainil Ridwanto Ridwanto