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All Journal Jurna Beta Kimia
Marliana, Eva Syaiful
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Chemical Engineering, Chemistry & Bioengineering Chemistry Education

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Strategies and Solutions in Overcoming the Challenges of Lipase Utilization in Biodiesel Production: A Review Aulia, Cindy; Lase, Yuyun Krisdayanti; Annisa, Lutfillah Dini; Putri, Sauza Shafa Salsabila; Saputri, Dhista Dwi; Arif, Moh. Syaiful; Marliana, Eva Syaiful
Jurnal Beta Kimia Vol 5 No 1 (2025): Volume 5 Number 1, May 2025
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v5i1.21071

Abstract

Biodiesel production using lipase as a catalyst offers a more environmentally friendly approach compared to chemical catalysts. However, the application of lipase in industry still faces various challenges, such as high production costs, low enzyme stability, and longer reaction times. To address these constraints, various strategies have been developed. This review not only summarizes these strategies but also highlights recent approaches that are less commonly discussed in the literature, such as the use of non-alcohol routes with methyl acetate and the application of ultrasonic technology to improve conversion efficiency. Additionally, this review provides a fresh perspective by systematically comparing the effectiveness of various lipase immobilization methods and low-cost lipase sources. The uniqueness of this study lies in the comprehensive integration of conventional biocatalysis strategies and emerging innovative approaches. It is hoped that this approach will offer more practical and relevant guidance for the development of enzyme-based biodiesel production technologies, making lipase-based biodiesel production more efficient, economical, and sustainable, while contributing to the reduction of dependency on fossil fuels and the advancement of renewable energy.
A Karakterisasi Self Nanoemulsifying Drug Delivery System Dengan VCO Dan PEG 400 Sebagai Kosurfaktan: Review Jurnal Pasarrin, Theresia Adelia; Hadijah, Siti Nur; Selvi, Selvi Nur; Effendie, Andre Maulana; Arif, Moh. Syaiful; Marliana, Eva Syaiful
Jurnal Beta Kimia Vol 4 No 2 (2024): Volume 4, Nomor 2: November 2024
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v4i2.21193

Abstract

Jurnal ini membahas karakterisasi Self Nanoemulsifying Drug Delivery System (SNEDDS) yang menggunakan Virgin Coconut Oil (VCO) dan PEG 400 sebagai kosurfaktan. Tujuan dari penelitian ini adalah untuk mengevaluasi efektivitas SNEDDS dalam meningkatkan kelarutan obat lipofilik, khususnya yang termasuk dalam Biopharmaceutical Classification System (BCS) kelas II dan IV. VCO dipilih karena kemampuannya dalam mengikat surfaktan, sedangkan PEG 400 berfungsi untuk menurunkan tegangan permukaan dan meningkatkan emulsifikasi. Metode sonikasi digunakan untuk memproduksi SNEDDS, dengan pengukuran karakteristik meliputi ukuran droplet, zeta potensial, dan indeks polidispersitas. Hasil penelitian menunjukkan bahwa variasi konsentrasi VCO mempengaruhi ukuran droplet, dengan ukuran droplet yang diinginkan kurang dari 200 nm. Nilai zeta potensial dan indeks polidispersitas juga menunjukkan stabilitas dan keseragaman ukuran partikel dari sediaan. Penelitian ini memberikan wawasan tentang potensi SNEDDS dalam meningkatkan bioavailabilitas obat yang tidak larut dalam air. Dengan demikian, penggunaan VCO dan PEG 400 dalam SNEDDS dapat menjadi alternatif yang menjanjikan dalam pengembangan sediaan farmasi untuk obat lipofilik, serta meningkatkan efektivitas terapi obat yang bersifat hidrofob.
Co-Authors Annisa, Lutfillah Dini Arif, Moh. Syaiful Aulia, Cindy Effendie, Andre Maulana Hadijah, Siti Nur Lase, Yuyun Krisdayanti Pasarrin, Theresia Adelia Putri, Sauza Shafa Salsabila Saputri, Dhista Dwi Selvi, Selvi Nur