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All Journal Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam (JURRIMIPA) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Pengabdian Masyarakat dan Riset Pendidikan
Muhamad Iqbal Rhamadianto
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Humanities Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Other

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Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5991

Abstract

Hyperlipidemia is a condition in which lipid levels in the bloodstream (plasma) experience an imbalance in lipid levels, although it does not show severe symptoms but can trigger various serious diseases. Statins are used as the main therapy for antidyslipidemia, but with long-term use, statins cause various side effects such as muscle pain, muscle disorders and muscle discomfort. Indonesia has a variety of plants that have benefits for lowering blood cholesterol levels. To determine the potential of metabolite compounds contained in several plants as HMG-COA Reductase inhibitors, research can be carried out using molecular docking. The purpose of this literature study is to determine the comparison of compounds that have HMG-COA Reductase inhibitor inhibitor activity. The method used in compiling this literature study is from various national and international scientific articles published in the period 2020-2025. The natural compounds that have been studied have significant inhibitory activity against the HMG-CoA Reductase enzyme, namely from the 10 plants studied, Rhodomyrtus tomentosa has the best activity in inhibiting the HMG-CoA Reductase enzyme with an Affinity of the Binding value of -11.4 so that it has the potential to be further developed as a natural anti-cholesterol drug.
Studi in Silico dari Senyawa Turunan Flavonoid pada Bahan Alam sebagai Terapi Antinyeri dan Inflamasi dalam Menghambat COX 2 Balqis Khansa Rahmatillah; Anisa Humaira Pelupessy; Amelia Putri; Aisril Eka Pertiwi; Afiq Rabbani Majid; Muhamad Iqbal Rhamadianto
JURNAL RISET RUMPUN MATEMATIKA DAN ILMU PENGETAHUAN ALAM Vol. 4 No. 2 (2025): Agustus: Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrimipa.v4i2.6373

Abstract

Inflammation is the body's natural biological response to tissue injury, infection, or other harmful stimuli. Inflammatory processes play an important role in maintaining the body's homeostasis, but excessive or chronic inflammation can trigger various degenerative diseases, including arthritis, cancer, and cardiovascular disorders. One of the main mediators of inflammation is the enzyme cyclooxygenase-2 (COX-2), which is in charge of converting arachidonic acid into pro-inflammatory prostaglandins. Inhibition of COX-2 activity is an important strategy in controlling inflammation. Selective COX-2 inhibitors (Coxibs) have been developed to reduce the gastrointestinal side effects commonly caused by conventional nonsteroidal anti-inflammatory drugs (OAINS). However, the use of Coxibs still poses a significant cardiovascular risk, so the search for alternatives from natural ingredients continues. Flavonoid compounds, which are abundant in fruits, vegetables, teas, and spices, show great potential as natural COX-2 inhibitors. Flavonoids have a polyphenol structure that allows for strong interactions with COX-2 active sites through hydrogen bonding and hydrophobic forces. This study is a literature review that examines the potential of flavonoids from natural ingredients as COX-2 inhibitors based on an in silico approach. This method was carried out through a literature search on the Google Scholar database using the keywords "Flavonoid", "COX-2", "In Silico", "Molecular Docking", and "Anti-inflammatory". The results of the analysis of ten articles showed that compounds such as myricetin, quercetin, rutin, catechin, and epicatechin-3-O-gallate have a high bonding affinity with COX-2, even exceeding in some cases standard drugs such as diclofenac and dexamethasone. Low bond energy values (ΔG) and optimal amount of hydrogen bonds support this potential. The findings indicate that flavonoids from natural ingredients can be developed into candidates for selective anti-inflammatory drugs COX-2 that are safer and more effective than existing synthetic therapies.
Edukasi Pencegahan Bullying Terhadap Anak Sekolah Dasar Pelag di Wilayah Desa Nagrak: Pengabdian Abdul Gafur Josan; Andi Nadia Zata Amani; Arkaan Zachary Hermawan; Asyifa Nuramalia; Fahrul Assalam; Rafli Fathur Rahman; Rahmah Syahidah; Shera Lusiana Putri; Shofura Naila Syahidatulhaq; Sri Yulandasari Lajai Mandam; Muhamad Iqbal Rhamadianto
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2507

Abstract

Bullying is a serious issue in the educational environment that significantly affects children’s psychological and social development. This problem is still prevalent at the elementary school level, including at SDN Pelag in Nagrak Village, which highlights the need for preventive measures through education. This community service activity aimed to improve students’ understanding of bullying, covering its definition, types, impacts, and prevention strategies. The method employed was a quasi-experimental approach using a pre-test and post-test design, combined with participatory education through interactive discussions, Q&A sessions, self-reflection, and psychoeducation. The program involved 87 students from grades III to VI. The analysis results indicated a significant increase in students’ knowledge, shown by an improvement from 77% in the pre-test to 91% in the post-test. These findings demonstrate that participatory education effectively fosters awareness among students to reject bullying and helps create a safe and comfortable school environment. This program is expected to serve as a sustainable bullying prevention model through collaboration among schools, teachers, and parents.
Budidaya Maggot BSF: Solusi Sampah Organik dan Pakan Ternak Lele di Desa Nagrak: Pengabdian Fadhillah Azzahra; Musyafa Abdillah; R.M. Abdurrohim; Amelia Putri; Shani Azhara; Shaumy Adellya N; Aldi Zaidahanis; Salman Herlambang; Fajar Yunawwirudin Haq; Siti Rahmawati; Muhamad Iqbal Rhamadianto
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2508

Abstract

The Community Service Program (KKN) conducted by Muhammadiyah University of Bandung in Nagrak Village aims to empower the community in maintaining environmental cleanliness in accordance with the potential of the region and available human resources. Specifically, this activity is aimed at enabling students to identify problems, foster community awareness of the environment, and encourage the community to cultivate Black Soldier Fly (BSF) Maggots as an alternative for managing organic waste. The research used a qualitative approach through field surveys, interviews, and secondary data analysis. The survey was conducted to determine the condition of waste management, while interviews with village officials, community leaders, and youth aimed to explore needs and appropriate solutions. The Maggot management program was implemented with an educational approach through socialization, namely providing an understanding of the differences between organic and non-organic waste and the benefits of Maggots in decomposing organic waste quickly and efficiently. The results of the activity showed an increase in community understanding and awareness in sorting waste, as well as the use of Maggots as alternative feed, for example for catfish. Thus, Maggot management not only contributes to reducing the volume of organic waste but also opens up new, environmentally friendly economic opportunities.
Co-Authors Abdul Gafur Josan Afiq Rabbani Majid Aisril Eka Pertiwi Aldi Zaidahanis Amelia Putri Andi Nadia Zata Amani Anisa Humaira Pelupessy Arkaan Zachary Hermawan Asyifa Nuramalia Balqis Khansa Rahmatillah Fadhillah Azzahra Fahrul Assalam Fajar Yunawwirudin Haq Hilma Marisa Indah Lestari Jelita Septiani Jihan Al Ihsani Khansa Aliifah Musyafa Abdillah R.M. Abdurrohim Rafli Fathur Rahman Rahmah Syahidah Salman Herlambang Shani Azhara Shaumy Adellya N Shera Lusiana Putri Shofura Naila Syahidatulhaq Siti Rahmawati Sri Yulandasari Lajai Mandam