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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Pengabdian Masyarakat dan Riset Pendidikan
Hilma Marisa
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Humanities Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Other

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Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5991

Abstract

Hyperlipidemia is a condition in which lipid levels in the bloodstream (plasma) experience an imbalance in lipid levels, although it does not show severe symptoms but can trigger various serious diseases. Statins are used as the main therapy for antidyslipidemia, but with long-term use, statins cause various side effects such as muscle pain, muscle disorders and muscle discomfort. Indonesia has a variety of plants that have benefits for lowering blood cholesterol levels. To determine the potential of metabolite compounds contained in several plants as HMG-COA Reductase inhibitors, research can be carried out using molecular docking. The purpose of this literature study is to determine the comparison of compounds that have HMG-COA Reductase inhibitor inhibitor activity. The method used in compiling this literature study is from various national and international scientific articles published in the period 2020-2025. The natural compounds that have been studied have significant inhibitory activity against the HMG-CoA Reductase enzyme, namely from the 10 plants studied, Rhodomyrtus tomentosa has the best activity in inhibiting the HMG-CoA Reductase enzyme with an Affinity of the Binding value of -11.4 so that it has the potential to be further developed as a natural anti-cholesterol drug.
Inovasi Produk Ramah Lingkungan: Ember Tumpuk sebagai Solusi Pengelolaan Limbah Rumah Tangga dan Pembuatan Lilin Aromaterapi dari Minyak Jelantah: Pengabdian Hani Humaeriyah; Hilma Marisa; Putri Rahmawati; Firda Fauziyyah; Nada Salma Salsabila; Azzahra Nur Khoiriyah; Martindo Alexander; Muthia Tsabita; Zahra Shabira Nikmati; Sofwan Adima Nurfadillah; Muhammad Hilman
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2538

Abstract

The issue of household waste management remains a significant challenge in society, including in Bongkok Village, Paseh Subdistrict, Sumedang Regency. Low awareness and limited utilization of waste often lead to environmental pollution and potential health problems. Through the Community Service Program Kuliah Kerja Nyata (KKN) of Universitas Muhammadiyah Bandung, Group 27 conducted educational and training activities for the community, especially housewives, on managing used cooking oil (minyak jelantah) and organic waste by applying the 3R concept (reduce, reuse, recycle). The innovation introduced includes processing household waste into aromatherapy candles made from used cooking oil, providing economic value while being environmentally friendly. Meanwhile, organic waste is processed into compost and liquid fertilizer using the stacked bucket method (ember tumpuk). This program aims to improve the community’s knowledge, skills, and awareness of responsible waste management while offering practical solutions to reduce environmental pollution. The results show an increase in community enthusiasm and understanding of the importance of proper household waste management. It is expected that, through this activity, the community will become more independent and actively contribute to creating a cleaner, healthier, and more productive environment.
Co-Authors Azzahra Nur Khoiriyah Firda Fauziyyah Hani Humaeriyah Indah Lestari Jelita Septiani Jihan Al Ihsani Khansa Aliifah Martindo Alexander Muhamad Iqbal Rhamadianto Muhammad Hilman Muthia Tsabita Nada Salma Salsabila Putri Rahmawati Sofwan Adima Nurfadillah Zahra Shabira Nikmati