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All Journal Medicinus : Jurnal Kedokteran Jurnal Sehat Indonesia (JUSINDO)
Sugianto, Michael Aquilar
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Therapeutic Potential of Neural Stem Cell in Ischemic Stroke: A Systematic Review Periyanto, Toni; Putri, Evira Agustina; Romano, Sultan Adhitya; Riantiarno, Chairizia; Kamal, M. Aulady Rifki; Aulia, Indri Noer; Sugianto, Michael Aquilar
Medicinus Vol. 14 No. 3 (2025): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i3.10165

Abstract

Background: Ischemic stroke remains a leading cause of disability and mortality worldwide, with over 12 million new cases annually and limited treatment options confined to narrow therapeutic windows. Neural stem cells (NSCs) have emerged as a promising therapeutic avenue due to their ability to self-renew, differentiate into all neural lineages, and exert paracrine effects that modulate inflammation and promote neurogenesis. Preclinical studies have demonstrated functional improvements of up to 60% in animal stroke models, but a systematic evaluation of these findings is needed to inform future clinical applications. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Databases searched included PubMed, EMBASE, and Scopus, covering literature up to May 8, 2025. Inclusion criteria comprised in vivo preclinical studies investigating NSC transplantation in animal models of ischemic stroke with at least one neurological, infarct, or histological outcome. Data extraction and risk of bias assessment (ROBINS-I) were independently performed by three reviewers. Due to study heterogeneity, a narrative synthesis was undertaken. Result: Eight studies met the inclusion criteria. NSC therapy improved neurological recovery in over 80% of cases, reduced infarct volume by up to 40%, and downregulated pro-inflammatory and apoptotic markers. Benefits were dose- and timing-dependent, with intracerebral and intravenous routes demonstrating variable efficacy. One study reported tumorigenicity, highlighting the need for safety profiling. Conclusions: Preclinical evidence supports the therapeutic potential of NSCs in ischemic stroke through neuroprotective and neurorestorative mechanisms. High-certainty findings justify continued investigation in clinical trials to refine dosing, delivery, and safety protocols.
Penatalaksanaan Hiperurisemia, Dislipidemia dan Obesitas Melalui Pendekatan Kedokteran Keluarga Sugianto, Michael Aquilar; Susanto, Tirta Darmawan; Moningkey, Shirley
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 2 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i2.314

Abstract

Hiperurisemia merupakan suatu kondisi di mana kadar asam urat terlampaui dalam tubuh. Jika tidak segera diobati, hiperemia dapat menyebabkan pembentukan kristal gout, yang dapat menyebabkan gout dan batu ginjal. Dislipidemia adalah penyakit yang ditandai dengan kadar kolesterol, LDL, HDL, dan trigliserida, yang tidak normal. Kondisi ini dapat disebabkan oleh gaya hidup yang tidak sehat atau gangguan genetik. Dislipidemia sering berubah hanya ketika komplikasi seperti stroke atau serangan jantung terjadi. Obesitas adalah akumulasi lemak yang berlebihan karena ketidakseimbangan penyerapan energi (asupan energi), dan energi digunakan untuk waktu yang lama (pengeluaran energi). Laporan kasus ini bertujuan untuk membahas lebih lanjut peran dokter umum untuk mencegah dan mengurangi komplikasi dari tiga jenis penyakit, termasuk batu ginjal, garis keturunan, serangan jantung dan penyakit metabolisme lainnya. Kedokteran keluarga memainkan peran penting dalam deteksi, pencegahan dan manajemen tiga penyakit. Pendekatan kedokteran keluarga menekankan intervensi preventif, pendidikan pasien dan manajemen jangka panjang. Pendekatan ini berharap bahwa pasien dan keluarga mereka akan meningkatkan pentingnya mengelola tiga jenis penyakit..
Co-Authors Aulia, Indri Noer Kamal, M. Aulady Rifki Moningkey, Shirley Periyanto, Toni Putri, Evira Agustina Riantiarno, Chairizia Romano, Sultan Adhitya Susanto, Tirta Darmawan