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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Medicinus : Jurnal Kedokteran
Periyanto, Toni
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Humanities Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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The Therapeutic Potential of Neural Stem Cell in Ischemic Stroke: A Systematic Review Periyanto, Toni; Putri, Evira Agustina; Romano, Sultan Adhitya; Riantiarno, Chairizia; Kamal, M. Aulady Rifki; Aulia, Indri Noer; Sugianto, Michael Aquilar
Medicinus Vol. 14 No. 3 (2025): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i3.10165

Abstract

Background: Ischemic stroke remains a leading cause of disability and mortality worldwide, with over 12 million new cases annually and limited treatment options confined to narrow therapeutic windows. Neural stem cells (NSCs) have emerged as a promising therapeutic avenue due to their ability to self-renew, differentiate into all neural lineages, and exert paracrine effects that modulate inflammation and promote neurogenesis. Preclinical studies have demonstrated functional improvements of up to 60% in animal stroke models, but a systematic evaluation of these findings is needed to inform future clinical applications. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Databases searched included PubMed, EMBASE, and Scopus, covering literature up to May 8, 2025. Inclusion criteria comprised in vivo preclinical studies investigating NSC transplantation in animal models of ischemic stroke with at least one neurological, infarct, or histological outcome. Data extraction and risk of bias assessment (ROBINS-I) were independently performed by three reviewers. Due to study heterogeneity, a narrative synthesis was undertaken. Result: Eight studies met the inclusion criteria. NSC therapy improved neurological recovery in over 80% of cases, reduced infarct volume by up to 40%, and downregulated pro-inflammatory and apoptotic markers. Benefits were dose- and timing-dependent, with intracerebral and intravenous routes demonstrating variable efficacy. One study reported tumorigenicity, highlighting the need for safety profiling. Conclusions: Preclinical evidence supports the therapeutic potential of NSCs in ischemic stroke through neuroprotective and neurorestorative mechanisms. High-certainty findings justify continued investigation in clinical trials to refine dosing, delivery, and safety protocols.
Pengaruh Ewom, Outcome Quality, Service Encounter dan Price Reasonable Terhadap Revisit Intention yang dimediasi Patient Satisfaction Periyanto, Toni; Ardi, Ardi; Sunarjo, Richard Andre
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i9.16677

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Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang mempengaruhi niat kunjungan kembali pasien di Klinik Estetika UAC di Jakarta Barat. Penelitian ini menguji pengaruh eWOM, kualitas hasil (outcome quality), interaksi layanan (service encounter), dan kewajaran harga (price reasonableness) terhadap niat berkunjung kembali (revisit intention), dengan kepuasan pasien (patient satisfaction) sebagai variabel mediasi. Kerangka pemikiran penelitian ini dirancang untuk menjawab bagaimana variabel-variabel independen tersebut dapat memberikan pengaruh positif terhadap variabel dependen. Penelitian ini dilakukan pada pasien di Klinik Estetika UAC yang berdomisili di Jabodetabek, dengan jumlah sampel ditentukan menggunakan perangkat lunak G*Power untuk Regresi Linier Berganda, menghasilkan 151 responden. Analisis data dilakukan menggunakan PLS Structural Equation Modelling(SEM) dengan bantuan Smart PLS versi 4.1.0.0. Hasil penelitian menunjukkan bahwa eWOM, outcome quality, dan service encounterberpengaruh signifikan terhadap patient satisfaction, tetapi tidak berpengaruh terhadap revisit intention. Sementara itu, Price reasonable berpengaruh signifikan terhadap patient satisfaction dan revisit intention, serta patient satisfaction berpengaruh signifikan terhadap revisit intention. Dari hasil penelitian ini, dapat disimpulkan bahwa variabel eWOM, outcome quality, dan service encountertidak cukup kuat dalam mempengaruhi keputusan untuk berkunjung kembali jika tidak diikuti oleh kepuasan pasien.
Co-Authors Ardi Ardi Aulia, Indri Noer Kamal, M. Aulady Rifki Putri, Evira Agustina Riantiarno, Chairizia Romano, Sultan Adhitya Sugianto, Michael Aquilar Sunarjo, Richard Andre