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All Journal Medicinus : Jurnal Kedokteran COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Amly, Harzalina Zilfi
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Humanities Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences

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Vaccine-Based Immunotherapy for Metastatic Colorectal Cancer: A Systematic Review Amelia, Sesa; Mathlubaa, Asya; Amly, Harzalina Zilfi; Jacobs, Christin Yosefin; Halim, Kurnia; Heriawan, Timotius Ivan; Guantoro, Vincent; Putri, Hesti Andika
Medicinus Vol. 14 No. 3 (2025): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i3.10166

Abstract

Background: Metastatic colorectal cancer (mCRC) remains a therapeutic challenge, particularly in microsatellite stable (MSS) tumors, which are largely unresponsive to current immunotherapy approaches. Vaccine-based immunotherapy offers a strategy to elicit tumor-specific immune responses in these immunologically “cold” tumors. However, clinical results have been mixed, and the efficacy and safety of cancer vaccines in mCRC remain to be clarified. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines. Randomized controlled trials (RCTs) evaluating vaccine-based immunotherapy in mCRC were identified from PubMed, EMBASE, and Scopus as of May 2, 2025. Eligible studies included human subjects with mCRC receiving vaccine therapy with or without additional treatments, compared to standard or placebo regimens. The primary outcomes were overall survival (OS) and progression-free survival (PFS); safety was assessed by the incidence of grade ≥3 treatment-related adverse events. Result: Five RCTs comprising 804 patients met inclusion criteria. Pooled analysis showed a trend toward improved OS with vaccine-based immunotherapy (HR 0.81; 95% CI, 0.65–1.00; p = 0.05; I² = 0%), and a modest, non-significant improvement in PFS (HR 0.80; 95% CI, 0.62–1.05; p = 0.07; I² = 0%). The incidence of severe adverse events was lower with vaccine-based therapies (RR 0.31; 95% CI, 0.02–6.09; p = 0.23; I² = 90%). Conclusions: Vaccine-based immunotherapy in mCRC demonstrates potential clinical benefit, particularly in prolonging survival with a favorable safety profile. Further biomarker-driven studies are needed to optimize patient selection and therapeutic combinations.
The NGAL serum level in patient with contrast-induced nephropathy (CIN): a systematic review and meta-analysis Amly, Harzalina Zilfi; Sitorus, Igna Laurensus; sitepu, Evi ananta ulisa
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 8 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i8.2714

Abstract

Contrast media are commonly injected into the bloodstream to increase image contrast and improve the diagnostic capabilities of radiological examinations. Contrast-induced nephropathy (CIN) is a severe complication of renal impairment after administration of contrast media. NGAL is a reliable early biomarker that has been studied in contrast to kidney damage and other conditions that affect the kidney. This study aimed to determine the mean difference in serum NGAL levels between patients with and non-CIN which will be used as the cutoff value for predicting CIN.  The search was performed using three databases with the following eligibility criteria: (1) adult patients (> 18 years old), (2) patients who underwent the procedure with contrast medium injection, and (3) diagnosis of CIN based on the increase in serum creatinine level after contrast infusion. Meta-analysis was performed using a random-effect model. The mean difference (MD) and confidence interval of serum NGAL (ng/mL) between CIN and non-CIN after contrast media injection based on nine studies (1,293 subjects) was 84.14 (95% CI: 48.90, 119.38) ng/mL. Egger’s regression test showed significant asymmetry in the funnel plot (p < .0001). This study found a positive difference in serum NGAL levels between patients with and without CIN after contrast medium injection.
Co-Authors Amelia, Sesa Guantoro, Vincent Halim, Kurnia Heriawan, Timotius Ivan Jacobs, Christin Yosefin Mathlubaa, Asya Putri, Hesti Andika sitepu, Evi ananta ulisa Sitorus, Igna Laurensus