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All Journal Indonesian Journal of Global Health research
Silaban, Roy Efendi
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Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Neutrophil-To-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as Predictors of Mortality in Chronic Kidney Disease Patients Undergoing Hemodialysis Silaban, Roy Efendi; Arto, Nindia Sugih; Lubis, Mohammad Riza
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6998

Abstract

Chronic Kidney Disease (CKD) is associated with high mortality, especially among patients undergoing hemodialysis (HD). Inflammation markers such as the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) have been linked to mortality prediction. This study aims to evaluate the role of NLR and PLR as mortality predictors in CKD patients undergoing HD at H. Adam Malik Hospital, Medan. This retrospective study analyzed CKD patients receiving HD from January to December 2023, aged 18-60 years, and undergoing routine HD for at least 3 months. Excluded were those with comorbidities, immunosuppressant use, or incomplete records. Data on demographics, laboratory values (including NLR and PLR), and mortality outcomes were collected. ROC curve and logistic regression analysis were used. Out of 108 patients, 35 (32.4%) died. The median NLR was significantly higher in the mortality group (7.89 vs. 3.41, p < 0.001), while PLR showed no significant difference. ROC analysis revealed NLR's moderate accuracy (AUC = 73.3%, cut-off = 5). Multivariate analysis identified coronary artery disease history, age, and creatinine levels as significant mortality factors. NLR is a moderate predictor of mortality in CKD patients undergoing HD, while PLR is not.
Co-Authors Lubis, Mohammad Riza Nindia Sugih Arto, Nindia Sugih