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All Journal JK Unila (Jurnal Kedokteran Universitas Lampung) Indonesian Journal of Life Sciences Indonesian Journal of Biomedicine and Clinical Sciences JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Maya Ulfah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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West Sumatera curd effect on fecal IgA and IgG in BALB/c mice colon inflammation induced by dextran sodium sulphate Utami, Diah Dwi; Yasmon, Andi; Heri Wibowo; Maya Ulfah; Ibnu Agus Ariyanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17334

Abstract

Curd, a fermented buffalo milk product from West Sumatra, is known for its probiotic content. Probiotics are recognized for their health benefits, including potential advantages for inflammatory bowel disease (IBD). Previous studies have confirmed the probiotic status of curd. However, the effects of curd on the immunoglobulin response in colon inflammation are still not well understood. This study employs an experimental design to investigate the impact of curd on the levels of total immunoglobulins A (IgA) and G (IgG) in feces and analyze the correlation between total IgA levels in feces and IL-10 expression in serum and feces and total IgG levels in feces and TNF-α expression in serum and feces of BALB/c with colon inflammation. In the normal group, curd administration significantly increased total IgA levels in feces, indicating a potential modulation of the immune response. Conversely, in the inflammatory group, curd reduced total IgA levels, though this effect was not statistically significant. Similarly, while curd reduced total IgG levels in feces for both the normal and inflammatory groups, the reduction was not statistically significant. No significant relationships were found between total IgA levels in feces and IL-10 expression in serum and feces, nor between total IgG levels in feces and TNF-α expression in serum and feces.
EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) BAGI KELOMPOK PENGAJIAN SITI KHODIJAH-MASJID AL-HIDAYAH DI KELURAHAN RAJABASA RAYA BANDAR LAMPUNG Ulfah, Maya; Nurfatihah Z, Zahara; Hijami, Nurul Afifah; Andriansyah; Permana, Muhammad Aditya
JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Vol. 10 No. 2 (2025): JURNAL PENGABDIAN MASYARAKAT RUWA JURAI
Publisher : FK Unila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpmrj.v10i2.3759

Abstract

Lansia dan kelompok ibu rumah tangga memiliki peran krusial dalam kesehatan keluarga, namun sering menghadapi tantangan fisik dan pengetahuan terkait Perilaku Hidup Bersih dan Sehat (PHBS). Pengabdian ini bertujuan memberikan edukasi PHBS kepada kelompok ibu-ibu pengajian Siti Khodijah di Masjid Al-Hidayah, Kelurahan Rajabasa, Bandar Lampung. Metode kegiatan menggunakan pendekatan penyuluhan interaktif dan tanya jawab, dengan efektivitas yang diukur melalui desain pre-test dan post-test pada 22 orang peserta. Hasil evaluasi awal (pre-test) menunjukkan tingkat pengetahuan peserta sebesar 86,3% (kategori Tinggi). Setelah intervensi edukasi, terjadi peningkatan skor post-test menjadi 90,8% (kategori Tinggi). Peningkatan ini membuktikan bahwa materi edukasi berhasil memperdalam pemahaman peserta terkait sanitasi dan kebiasaan sehat. Disimpulkan bahwa edukasi kesehatan interaktif efektif sebagai upaya pemberdayaan masyarakat dalam meningkatkan penerapan PHBS di lingkungan rumah tangga secara berkelanjutan.
Mekanisme Respons Imun terhadap Infeksi Sekunder pada Severe Dengue: Sebuah Tinjauan Pustaka Ulfah, Maya
Jurnal Kedokteran Universitas Lampung Vol. 9 No. 2 (2025): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila.v9i2.pp318-327

Abstract

Dengue merupakan salah satu penyakit infeksi arbovirus (arthropod-borne virus) yang ditemukan pada sekitar 100 negara baik tropis maupun subtropis di seluruh dunia. Mekanisme yang menyebabkan timbulnya keparahan bahkan berujung pada kematian dalam infeksi DENV (severe Dengue) masih belum dipahami secara baik. Meskipun demikian, beberapa penelitian yang berkaitan dengan respons imun di dalam tubuh dan peranannya dalam infeksi severe Dengue telah banyak dilakukan. Hipotesis umum yang paling dapat diterima untuk terjadinya severe Dengue adalah infeksi sekunder yang disebabkan oleh serotipe DENV yang berbeda. Sel-T memori yang terbentuk selama infeksi primer dapat bereaksi dengan cepat, tetapi memiliki efektivitas yang lebih rendah daripada sel-T naïve selama proses infeksi sekunder non-spesifik terjadi. Proses tersebut mengakibatkan terjadinya respons imun yang tidak efisien dengan deregulasi produksi cytokine. Teori tersebut juga dikenal dengan istilah original antigenic sin. Hipotesis lainnya yang juga masih berkaitan dengan original antigenic sin, yaitu Antibody Dependent Enhancement (ADE). Berdasarkan teori ADE, non-spesifik antibodi yang diproduksi selama proses infeksi sekunder dengan serotipe heterologous mengakibatkan serapan dan replikasi virus yang lebih tinggi di dalam sel target, seperti yang terjadi pada sel monosit melalui reseptor Fc. Pemahaman yang baik mengenai kedua hipotesis tersebut dapat sangat bermanfaat untuk memahami kejadian DHF/DSS pada infeksi DENV.
Smartphone Use and Musculoskeletal Disorders: A Systematic Review of Epidemiological Evidence and Potential on Inflammatory Mechanisms Hijami, Nurul Afifah; Ulfah, Maya
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.301

Abstract

Smartphone use among adults has increased and often involves prolonged exposure with sustained non-neutral neck posture. Epidemiological studies report a high prevalence of neck and shoulder pain among frequent users. Biomechanical loading of the cervical spine is considered a main mechanism, while inflammatory processes have been proposed as an additional pathway. This systematic review evaluated the association between smartphone use and musculoskeletal complaints, focusing on inflammatory biomarkers as a potential biological mechanism. The review followed PRISMA 2020 guidelines. Searches were conducted in PubMed and ScienceDirect for peer-reviewed studies published between 2018 and 2025. Eligible studies included adults aged 18 years or older who reported smartphone use exceeding 2 to 3 hours per day. Exposure was commonly assessed using self-report questionnaires or structured surveys. Studies examining neck or shoulder outcomes, posture, or inflammatory biomarkers were included. Observational studies, randomized controlled trials, and ergonomic interventions were eligible. Thirty studies met the inclusion criteria. Most reported significant associations between prolonged smartphone use, sustained neck flexion, and musculoskeletal pain in the neck and shoulders. Prevalence ranged from moderate to high among students and workers with a daily use of 3 to 9 hours. No included study directly measured inflammatory biomarkers in general smartphone users. Related evidence indicates elevated IL-6 and C-reactive protein in sedentary populations with high device exposure.
Co-Authors Andi Yasmon ANDRIANSYAH Heri Wibowo Hijami, Nurul Afifah Ibnu Agus Ariyanto Nurfatihah Z, Zahara Permana, Muhammad Aditya Utami, Diah Dwi