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All Journal JOURNAL SCIENTIFIC OF MANDALIKA (JSM) IPSSJ
Asfarina Prihandini
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Humanities Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Public Health Social Sciences Other

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Fenomena Sound Horeg dan Ancaman Tersembunyi: Kajian Hipotetik NIHL dan Dampak Pada Fungsi Kognitif Asfarina Prihandini; Jodii Arlan Kurnia
Integrative Perspectives of Social and Science Journal Vol. 2 No. 03 Agustus (2025): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Fenomena sound horeg, yaitu penggunaan sistem audio berdaya tinggi dalam acara sosial masyarakat Indonesia, telah menjadi bagian dari ekspresi budaya yang dilegitimasi secara sosial. Namun, praktik ini menyimpan potensi risiko kesehatan yang sering diabaikan, yaitu terhadap pendengaran. Paparan suara keras berulang dapat menyebabkan Noise-Induced Hearing Loss (NIHL). NIHL adalah gangguan pendengaran permanen akibat kerusakan sel rambut koklea. Lebih jauh, NIHL juga berhubungan dengan penurunan fungsi kognitif melalui berbagai mekanisme, seperti auditory deprivation, Cognitive load theory, dan Social isolation pathway. Kajian ini bertujuan untuk merumuskan hipotesis konseptual mengenai keterkaitan antara fenomena sound horeg, NIHL, dan penurunan kognitif. Metode yang digunakan adalah kajian literatur terhadap studi-studi relevan dari 2010–2025 yang membahas paparan kebisingan, NIHL, dan dampak kognitifnya. Hasil studi menunjukkan adanya kebutuhan mendesak untuk memahami dampak jangka panjang dari kebisingan oleh sound horeg terhadap kesehatan masyarakat. Kajian ini menjadi langkah awal untuk membuka diskursus ilmiah, mendorong penelitian primer di Indonesia, serta menyusun kebijakan mitigasi kebisingan pada acara budaya lokal.
Mekanisme Suplementasi Magnesium Glycinate Sebagai Terapi Adjuvan pada Pasien Depresi Asfarina Prihandini; Jodii Arlan Kurnia
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 6 No. 11 (2025)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol6iss11pp4245-4250

Abstract

Depression is a mood disorder characterized by feelings of sadness, loss of interest, and energy deficit. Furthermore, depression can lead to cognitive and somatic disorders, even suicidal ideation. Pharmacological therapy using antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) has proven effective but has several side effects. In the last decade, attention has shifted to micronutrients such as magnesium glycinate as adjuvant therapy. This literature review analyzes the latest scientific evidence regarding the neurobiological mechanisms of magnesium glycinate in supporting the management of depression. Magnesium glycinate works through several mechanisms; N-Methyl-D-Aspartate (NMDA) receptor antagonism to prevent excitotoxicity; modulation of monoamine and Gamma-Aminobutyric Acid (GABA) neurotransmitters for mood stabilization; increasing Brain Derived Neurotrophic Factor (BDNF) to support neuroplasticity; modulation of the hypothalamic-pituitary-adrenal axis (HPA axis); reduction of proinflammatory cytokines. Magnesium glycinate has high bioavailability and good gastrointestinal tolerance, making it promising as an adjunctive depression therapy and opening up opportunities for further clinical research.
Co-Authors Jodii Arlan Kurnia