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All Journal JOURNAL SCIENTIFIC OF MANDALIKA (JSM) IPSSJ
Jodii Arlan Kurnia
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Humanities Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Public Health Social Sciences Other

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The Relationship Between Dysbiosis in Geriatrics and the Risk of HMPV: A Literature Review Adnexa Miftah Firdausy; Adib Danurdipta; Jodii Arlan Kurnia
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 6 No. 9 (2025)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol6iss9pp3686-3694

Abstract

This study investigates the relationship between dysbiosis in the geriatric population and the increased risk of Human Metapneumovirus (HMPV) infection through a literature review. The aim of the study is to identify the underlying pathophysiological mechanisms by which dysbiosis affects the immune system, particularly via the gut-lung axis, and its implications for HMPV infection risk. A systematic review was conducted on reputable journals published over the last 10 years (2015–2025) by searching PubMed, Scopus, and ScienceDirect using the keywords "dysbiosis," "geriatrics," "HMPV," "respiratory infection," and "gut-lung axis." The findings indicate that elderly individuals experience a decrease in gut microbiota diversity and an increase in pathogenic bacteria, contributing to a state of inflammaging. This disturbance leads to increased intestinal permeability and the translocation of endotoxins into systemic circulation, which in turn causes excessive immune activation. A reduction in the production of anti-inflammatory short-chain fatty acids (SCFA) was also observed, weakening the immune response to viral infections, including HMPV. The data suggest that the elderly with dysbiosis are at a higher risk of developing serious complications from HMPV, such as pneumonia and exacerbation of pulmonary diseases.The implications of this study support the development of intervention strategies, including the administration of probiotics, prebiotics, and dietary modifications, to restore gut microbiota balance and enhance immune responses in the geriatric population. Although further clinical research is needed to fully elucidate these mechanisms, the findings provide a strong foundation for preventive interventions aimed at reducing the disease burden caused by HMPV.
Fenomena Sound Horeg dan Ancaman Tersembunyi: Kajian Hipotetik NIHL dan Dampak Pada Fungsi Kognitif Asfarina Prihandini; Jodii Arlan Kurnia
Integrative Perspectives of Social and Science Journal Vol. 2 No. 03 Agustus (2025): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Fenomena sound horeg, yaitu penggunaan sistem audio berdaya tinggi dalam acara sosial masyarakat Indonesia, telah menjadi bagian dari ekspresi budaya yang dilegitimasi secara sosial. Namun, praktik ini menyimpan potensi risiko kesehatan yang sering diabaikan, yaitu terhadap pendengaran. Paparan suara keras berulang dapat menyebabkan Noise-Induced Hearing Loss (NIHL). NIHL adalah gangguan pendengaran permanen akibat kerusakan sel rambut koklea. Lebih jauh, NIHL juga berhubungan dengan penurunan fungsi kognitif melalui berbagai mekanisme, seperti auditory deprivation, Cognitive load theory, dan Social isolation pathway. Kajian ini bertujuan untuk merumuskan hipotesis konseptual mengenai keterkaitan antara fenomena sound horeg, NIHL, dan penurunan kognitif. Metode yang digunakan adalah kajian literatur terhadap studi-studi relevan dari 2010–2025 yang membahas paparan kebisingan, NIHL, dan dampak kognitifnya. Hasil studi menunjukkan adanya kebutuhan mendesak untuk memahami dampak jangka panjang dari kebisingan oleh sound horeg terhadap kesehatan masyarakat. Kajian ini menjadi langkah awal untuk membuka diskursus ilmiah, mendorong penelitian primer di Indonesia, serta menyusun kebijakan mitigasi kebisingan pada acara budaya lokal.
Mekanisme Suplementasi Magnesium Glycinate Sebagai Terapi Adjuvan pada Pasien Depresi Asfarina Prihandini; Jodii Arlan Kurnia
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 6 No. 11 (2025)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol6iss11pp4245-4250

Abstract

Depression is a mood disorder characterized by feelings of sadness, loss of interest, and energy deficit. Furthermore, depression can lead to cognitive and somatic disorders, even suicidal ideation. Pharmacological therapy using antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) has proven effective but has several side effects. In the last decade, attention has shifted to micronutrients such as magnesium glycinate as adjuvant therapy. This literature review analyzes the latest scientific evidence regarding the neurobiological mechanisms of magnesium glycinate in supporting the management of depression. Magnesium glycinate works through several mechanisms; N-Methyl-D-Aspartate (NMDA) receptor antagonism to prevent excitotoxicity; modulation of monoamine and Gamma-Aminobutyric Acid (GABA) neurotransmitters for mood stabilization; increasing Brain Derived Neurotrophic Factor (BDNF) to support neuroplasticity; modulation of the hypothalamic-pituitary-adrenal axis (HPA axis); reduction of proinflammatory cytokines. Magnesium glycinate has high bioavailability and good gastrointestinal tolerance, making it promising as an adjunctive depression therapy and opening up opportunities for further clinical research.
TANTANGAN DIAGNOSIS TUBERKULOSIS TULANG PADA ANAK: LAPORAN KASUS DAN IMPLIKASI BAGI MANAJEMEN RUMAH SAKIT Corina Primanda Rahman; Jodii Arlan Kurnia
Integrative Perspectives of Social and Science Journal Vol. 2 No. 07 Desember (2025): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Pendahuluan: Tuberkulosis (TBC) tulang pada anak merupakan bentuk TBC ekstraparu yang jarang dan sering terlambat terdiagnosis karena gejala awal tidak spesifik serta keterbatasan pemeriksaan konvensional. Deskripsi Kasus: Dilaporkan seorang anak laki-laki usia 3 tahun dengan keluhan nyeri tungkai dan pincang progresif tanpa riwayat trauma. Pemeriksaan radiologi awal dan tes tuberkulin menunjukkan hasil tidak mendukung, sementara kondisi klinis memburuk hingga tidak dapat berjalan. Pemeriksaan lanjutan menunjukkan paraparese dan hasil TB-LAM urin positif. Pasien mendapat terapi obat anti-tuberkulosis fase intensif dan fisioterapi dengan perbaikan klinis signifikan setelah satu bulan. Pembahasan: Kasus ini menyoroti peran TB-LAM urin sebagai alat bantu diagnosis non-invasif pada TBC tulang anak ketika pemeriksaan standar tidak konklusif. Implikasi Manajerial: Diperlukan penguatan clinical pathway, sistem rujukan, dan akses diagnostik untuk mencegah keterlambatan diagnosis. Simpulan: Integrasi pendekatan klinis dan manajerial penting untuk meningkatkan luaran pasien TBC pediatrik.
Co-Authors Adib Danurdipta Adnexa Miftah Firdausy Asfarina Prihandini Corina Primanda Rahman