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All Journal Science and Technology Indonesia Communications in Science and Technology
Al Hafidl, Achmad Naufal
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Engineering Environmental Science Materials Science & Nanotechnology Physics

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Ionic liquid ultrasound-assisted extraction (IL-UAE) for duck feather keratin and in silico evaluation as a potential procollagen n-endopeptidase inhibitor Sianita, Maria Monica; Kusumawati, Nita; Asri, Mahanani Tri; Dzulkarnain, Shod Abdurrachman; Al Hafidl, Achmad Naufal; Kahfi, Ashabul; Nabila, Mutiara Azfa; Setiawan, Ferdiansyah; Isyrak, Luthfiyah; Rahmawati, Khofifatul
Communications in Science and Technology Vol 10 No 1 (2025)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.10.1.2025.1669

Abstract

This research aims to optimize keratin extraction from duck feathers using an eco-friendly ionic liquid-ultrasound-assisted extraction (IL-UAE) method and evaluate its potential applications in tissue engineering. It investigated the effects of deposition pH (1-6), ultrasonication temperature (40-60°C), and time (60-180 min) on extraction yield and physicochemical properties. The results demonstrated the optimal extraction conditions at pH 3, 40°C, and 60 minutes, yielding 82% keratin with a 0.50 mg/mL concentration, while the lowest yield production was found at pH 6 (33%, 0.20 mg/mL). Meanwhile, characterization via FTIR confirmed predominant ?-sheet structures with characteristic peaks at 3250-3300 cm?¹ (N-H/O-H stretching) and 1700-1500 cm?¹ (C=O stretching). SDS-PAGE revealed pure keratin bands (10-15 kDa), while SEM showed layered, porous morphology suitable for biomaterial applications. Thermogravimetric analysis, furthermore, identified three degradation stages occurred at 0-200°C (3.05% loss), 200-400°C (39.37% loss), and 400-700°C (31.13% loss). Amino acid profiling revealed high L-cystine content (153,064.90-156,926.33 mg/kg) with the significant amounts of glycine (63,958.25-64,064.73 mg/kg), L-proline (77,631.16-77,717.42 mg/kg), and L-leucine (59,111.43-59,198.60 mg/kg). In silico molecular docking studies identified leucine as a promising procollagen N-endopeptidase inhibitor (binding energy -5.0 kcal/mol), which controlled the collagen-breaking and forming process. This ability makes keratin potential to be developed as a scaffold for bone tissue regeneration in medical industry.
Effect of pH on Brazilin Extraction from Sappanwood (Caesalpinia sappan L.) and Its Impact on the Efficiency of Natural Dye-Sensitized Solar Cells (DSSCs) Al Hafidl, Achmad Naufal; Nita Kusumawati; Pirim Setiarso; Samik, Samik; Maria Monica Sianita Basukiwardojo; Khofifatul Rahmawati
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.378-388

Abstract

Dye-sensitized solar cells (DSSCs) are a sustainable photovoltaic technology for addressing the global energy crisis through the conversion of solar energy using photosensitive dyes. This study aims to investigate the effect of pH variation during extraction on the optical, electrochemical, and photovoltaic characteristics of brazilin dye from sappanwood (Caesalpinia sappan L.) for DSSC applications. Brazilian extraction was performed using Microwave-Assisted Extraction (MAE) with pH conditioning from 2 to 12. UV-Vis spectroscopy showed an increase in light absorbance at 400–800 nm. The pH 8 dye exhibited a maximum absorption peak at 444.59 nm due to the formation of a quinoidal base through partial deprotonation of the hydroxyl (-OH) group. FTIR characterization confirmed the chemical structure of the dye with characteristic absorption spectra of broad bands at 3000–3500 cm-1 for the phenolic hydroxyl group and peaks at 2800–3000 cm-1 for aromatic C-H stretching vibrations, as well as aromatic C=C and C=O stretching vibrations at 1600–1400 cm-1. Energy band gap analysis revealed that the dye at pH 2–12 has an energy gap range of 0.1788–0.5355 eV. Optimizing the extraction pH revealed that pH 8 yields the most effective dye performance, resulting in a peak DSSC efficiency of 2.17%, a minimal charge transfer resistance of 100 Ω, and the narrowest energy bandgap at 0.1788 eV. Weakly basic conditions enhance dye molecule conjugation, strengthen bonding with TiO2, and optimize the overall charge transfer process. The research findings confirm the potential of optimizing natural dye extraction conditions as a strategy to enhance DSSC efficiency in a sustainable and environmentally friendly manner.
Co-Authors Ashabul Kahfi, Ashabul Dzulkarnain, Shod Abdurrachman Isyrak, Luthfiyah Khofifatul Rahmawati Mahanani Tri Asri Maria Monica Sianita Maria Monica Sianita Basukiwardojo Nabila, Mutiara Azfa Nita Kusumawati Nita Kusumawati Pirim Setiarso Rahmawati, Khofifatul Samik Samik Setiawan, Ferdiansyah