In mathematics study, problem solving is an activity that plays an important role when learning mathematics. In the process of learning mathematics, it is important to apply models, methods and media that are appropriate to students' needs to support more interesting and easy-to-understand learning. This study aims to examine the effectiveness of the Guided Inquiry learning model assisted by ANVIPI media on the problem-solving abilities of fourth grade elementary school students. This study uses a quantitative method with a quasi-experimental design, the population in this study were students of SDN Susukan 01 and the sample in this study was class IV A as the experimental class while class IV B as the control class. Data collection techniques were in the form of tests and non-tests. The results of the study showed that there was a significant difference between the experimental and control classes. The average posttest score of the experimental group (75.64) was higher than the control class (72.79). The results of the Paired Sample T-test analysis showed a significance value of 0.00 <0.05, with the average pretest and posttest results of the experimental class showing 67.42 and 72.79. Therefore, it can be seen that there is an average increase between the pretest results and the posttest results of 5.37. This shows that the Guided Inquiry learning model has increased students' problem-solving abilities.