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All Journal JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH Jurnal Farmasi Kryonaut
Kusdiharti, Meutia Sri
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Anti-Inflammatory Potential of Fermented Red Ginger Extract (Zingiber officinale var. Rubrum) Against In Vitro Protein Denaturation Kusdiharti, Meutia Sri; Dewi, Ni Wayan Rika Kumara; Artika, Made Prita
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4093

Abstract

Background:Red ginger (Zingiber officinale var. Rubrum) is known for many phytochemical components and various pharmacological activities, such as anti-inflammation. However, red ginger also has a high cellulose level. Special treatment is needed to degrade the cellulose so that phytochemicals can be maximally extracted. Trichoderma harzianum, a cellulase enzyme-producing fungus, can degrade cellulose and increase the efficiency of phytochemical extraction. Aims:This study aimed to evaluate the in vitro anti-inflammatory potential of red ginger extract fermented with T. harzianum. Methods:This research is an experimental method involving the fermentation of red ginger powder before extraction, followed by an in vitro protein denaturation inhibition assay using a UV-Vis spectrophotometer. Bovine Serum Albumin (BSA) was used as a negative control, diclofenac sodium as a positive control, and the fermented red ginger extract (FRGE) was tested at concentrations of 25, 50, 75, 100, and 125 ppm. The results: Phytochemical screening of FRGE confirmed the presence of alkaloids, flavonoids, saponins, phenols, and triterpenoids. The extract yield was 14.29%, with the highest inhibition of protein denaturation at 62.62% observed at 125 ppm. The IC50 value is 93.61 ppm. Conclusions: Based on these research results, FRGE had strong antiinflammatory potency in vitro. Keywords: Red ginger, Fermentation, Anti-inflammatory, Protein denaturation, Trichoderma harzianum
PRODUCTION OF SECONDARY METABOLITES AND FORMULATION OF NANO SPRAY GEL RED GINGER (Zingiber officinale var.rubrum) FERMENTATION EXTRACT AS ANTIINFLAMATION Ni Wayan Rika Kumara Dewi; Made Dwike Swari Santi; Kusdiharti, Meutia Sri
Jurnal Farmasi Kryonaut Vol 4 No 1 (2025): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v4i1.115

Abstract

Red ginger (Zingiber officinale var.rubrum) has active compounds, namely gingerol and shogaol which provide anti-inflammatory activity. The purpose of this study was to improve the quality and quantity of secondary metabolites in red ginger extract through the fermentation process, as well as the development of nanoparticle technology in the formulation of natural pharmaceutical preparations in the form of nano spray gel as an anti-inflammatory. This research method is a true experimental laboratory, with a fermentation process using Trichoderma harzianum mold. Active compounds were analyzed using GCMS. In vitro, anti-inflammatory activity was tested using the protein denaturation method, negative control using bovine serum albumin, and positive control using sodium diclofenac (KP). Anti-inflammatory activity was tested on red ginger extract (EJM), red ginger fermentation extract (EFJM), nano spray gel (SNSG) preparations with active ingredients EFJM at F0 ; F1 ; F2 ; F3 ; and F4. The results showed an increase in yield after fermentation, from 8.03% to 14.3%. The active compounds analyzed also experienced an increase in the % area of abundance in the 6-gingerol compound from 1.23% to 5.43% and the 6-shogaol compound from 5.25% to 13.36%. The results of the anti-inflammatory activity test on SNSG F4 had an anti-inflammatory inhibition % of 89.35% at a concentration of 125 ppm. The IC50 value of all treatments obtained data EFJM> EJM> KP Nadik> F4> F2> F3> F1> F0. That Shows is a red ginger fermentation extract as an active ingredient in nanospray gel preparations can provide strong anti-inflammatory activity.
Co-Authors Artika, Made Prita Made Dwike Swari Santi Ni Wayan Rika Kumara Dewi