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Correlation Between Oxidative Stress, SIRT1 Serum Level, and eGFR on Elderly Harun, Harnavi; Veronike, Evelin; Kam, Alexander; Amelia, Rinita
Jurnal Penelitian Pendidikan IPA Vol 9 No 8 (2023): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i8.4916

Abstract

The aging network kidney causes Oxidative Stress (OS) and damages the kidney. Studies of aging kidneys keep going growing by developing sirtuin as an antiaging. Sirtuin 1 (SIRT1) is a protein implicated in several disorders including diabetes functions as an anti-aging protein. Decreased eGFR in the elderly caused by his height prevalence factor risk disease kidney at an older age. The study aims to study the correlation between oxidative stress, SIRT1 serum levels, and eGFR in the elderly.  The method used in this research is observational with the cross-sectional method. The sample in this study was the whole elderly who met the inclusion and exclusion criteria, totaling 30 people. Exclusion criteria are patients with glomerulonephritis, nephropathy obstruction, nephropathy sour veins, and obesity. All patients complied requirements asked to fill informed consent form. The inspection was carried out by urinalysis ultrasound kidney and assessing serum MDA levels which were found to be higher in this study. This study showed SIRT1 and eGFR levels decreased in the elderly. There was a negative correlation with moderate correlation strength between serum MDA levels and serum SIRT1 levels and a strong correlation between serum MDA levels and eGFR in the elderly. There was a positive correlation with a moderate correlation between serum SIRT1 levels and eGFR in the elderly. SIRT1 is suggested to be examined in elderly patients with decreased eGFR, even without comorbidity.
Associated Factors with Erectile Dysfunction in Hemodialysis Patients at Dr. Reksodiwiryo Hospital Padang Vidiansyah, Achmad; Putra, Mindy Pasuma; Veronike, Evelin; Harun, Harnavi
Indonesian Journal of Kidney and Hypertension Vol 2 No 3 (2025): Volume 2 No. 3, December 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i3.218

Abstract

Background: Erectile dysfunction (ED) is a common condition affecting a significant number of men worldwide, with its prevalence particularly high among patients with chronic kidney disease (CKD). Objective: This study aims to investigate the association between ED and CKD in patients undergoing hemodialysis. Methods: This study used a survey approach, designed with cross-sectional involving 24 male patients undergoing hemodialysis at the hospital from January to July 2024. Data were gathered using the IIEF-5 questionnaire as well as patient records. The severity of ED was classified based on IIEF-5 scores, and data analysis was conducted using SPSS. Results: Most respondents (58.3%) were under 60 years old, with 58.3% having hemoglobin levels below 10 g/dL and 79.2% with a KT/V ratio under 1.8. ED prevalence was high at 95.8%, with severe ED affecting 54.2%. A significant correlation existed between KT/V and ED severity p<0.05, while hemoglobin levels showed no significant association p>0.05. The high prevalence of ED in CKD patients undergoing hemodialysis highlights the importance of regular screening and early intervention. The study indicates that sufficient hemodialysis, as measured by the Kt/V ratio, could be essential in reducing the severity of ED in this group. However, hemoglobin levels did not show a significant connection to ED severity, which contrasts with certain earlier research findings. Conclusion: Erectile dysfunction is common among CKD patients undergoing hemodialysis, with insufficient dialysis being a key contributing factor. This highlights the need to maintain adequate dialysis to reduce the severity of ED in these individuals.