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All Journal Jurnal Sehat Mandiri Journal of Pharmaceutical and Sciences.
Piola, Okta
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Efektivitas Ekstrak Stevia (Stevia Rebaudiana) dalam Menurunkan Kadar Glukosa Darah: Suatu Tinjauan Literatur Piola, Okta; Septiani, Dia
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1743

Abstract

Diabetes Mellitus (DM) is a chronic disease with a steadily increasing global prevalence, creating an urgent need for effective blood glucose management strategies. One potential alternative is stevia (Stevia rebaudiana) leaf extract, which contains the main components stevioside and rebaudioside. This review aims to evaluate the effectiveness of stevia as an antidiabetic agent based on current literature analysis. Data were obtained through searches on Google Scholar and PubMed using inclusion criteria: original articles, published within the last 10 years, and focusing on the antidiabetic effects of stevia. The results indicate that stevia extract significantly reduces blood glucose levels, improves insulin sensitivity, and exhibits antioxidant properties through mechanisms involving genetic regulation, enhanced enzymatic activity, and reduced inflammation. In conclusion, stevia shows potential as a natural sweetener as well as a complementary therapy in diabetes management, offering additional benefits for lipid profile improvement and cardiovascular protection with minimal side effects. To ensure its long-term safety and efficacy, further human clinical trials with adequate design, extended follow-up periods, and the development of innovative formulations such as nano-stevia are recommended to enhance bioavailability.
Interaksi antara Herbal dan Antidiabetik Oral pada Penderita Diabetes Melitus: Tinjauan Mekanisme Aksi Shidiqiyah , Nurul Hafizha; Herlaesa , Shofiatulfuadah Retnaningrum; Piola, Okta; Hariadi, Nayla Nur Azkia; Basmalah, Nur; Putri , Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1207

Abstract

The increasing use of herbal products among patients with diabetes mellitus highlights the need for a clear understanding of their potential interactions with oral antidiabetic drugs (OADs). Such interactions may be synergistic or may pose risks, particularly hypoglycemia. To identify the mechanisms underlying interactions between herbal products and OADs and to assess their relevance in the management of type 2 diabetes mellitus. A literature search was conducted through Google Scholar, PubMed, and ScienceDirect using keywords related to herbal products, oral antidiabetic drugs, and drug interactions. Articles were selected based on inclusion criteria (2015–2025, original research, human subjects with type 2 diabetes mellitus or animal models, English or Indonesian language, and involving OADs) and relevant exclusion criteria. The most frequently reported interactions were pharmacodynamic, particularly the combination of Cinnamomum verum, Curcuma longa, and Momordica charantia with metformin or sulfonylureas, which enhanced insulin sensitivity, activated AMPK, or stimulated insulin secretion, potentially increasing the risk of hypoglycemia. Pharmacokinetic interactions were also identified, such as ginseng-induced modulation of the OCT1 transporter, which may influence metformin accumulation. Several other herbal products, including Aloe vera, demonstrated glucose-lowering activity; however, evidence of direct interactions with OADs remains limited, suggesting a primarily supportive role. Interactions between herbal products and oral antidiabetic drugs have important clinical implications, as they may alter both therapeutic efficacy and safety. Close monitoring and patient education are essential, alongside further research to clarify interactions that remain insufficiently documented.
Co-Authors Basmalah, Nur Hariadi, Nayla Nur Azkia Herlaesa , Shofiatulfuadah Retnaningrum Hilmi , Indah Laily Putri , Mukarromah Dita Septiani, Dia Shidiqiyah , Nurul Hafizha