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All Journal Jurnal Sehat Mandiri
Piola, Okta
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Environmental Science Public Health

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Efektivitas Ekstrak Stevia (Stevia Rebaudiana) dalam Menurunkan Kadar Glukosa Darah: Suatu Tinjauan Literatur Piola, Okta; Septiani, Dia
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1743

Abstract

Diabetes Mellitus (DM) is a chronic disease with a steadily increasing global prevalence, creating an urgent need for effective blood glucose management strategies. One potential alternative is stevia (Stevia rebaudiana) leaf extract, which contains the main components stevioside and rebaudioside. This review aims to evaluate the effectiveness of stevia as an antidiabetic agent based on current literature analysis. Data were obtained through searches on Google Scholar and PubMed using inclusion criteria: original articles, published within the last 10 years, and focusing on the antidiabetic effects of stevia. The results indicate that stevia extract significantly reduces blood glucose levels, improves insulin sensitivity, and exhibits antioxidant properties through mechanisms involving genetic regulation, enhanced enzymatic activity, and reduced inflammation. In conclusion, stevia shows potential as a natural sweetener as well as a complementary therapy in diabetes management, offering additional benefits for lipid profile improvement and cardiovascular protection with minimal side effects. To ensure its long-term safety and efficacy, further human clinical trials with adequate design, extended follow-up periods, and the development of innovative formulations such as nano-stevia are recommended to enhance bioavailability.
Co-Authors Septiani, Dia