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All Journal Jurnal Biologi Tropis Journal of Public Health Science (JoPHS)
Saputri, Rahmi Agu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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ANALISIS POLA TEKANAN DARAH PADA LANSIA DENGAN OBESITAS DI RSI SITI RAHMAH Saputri, Rahmi Agu; Anggraini, Debie; Adelin, Prima
Journal of Public Health Science Vol. 2 No. 2 (2025): Juni
Publisher : Yayasan Nuraini Ibrahim Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70248/jophs.v2i2.2876

Abstract

Penelitian ini bertujuan untuk menganalisis pola tekanan darah pada lansia dengan obesitas di RSI Siti Rahmah dan membandingkan tekanan darah sistolik serta diastolik berdasarkan jenis kelamin. Metode penelitian yang digunakan adalah deskriptif analitik dengan desain potong lintang (cross-sectional) pada lansia obesitas berusia ≥60 tahun yang tercatat dalam rekam medis RSI Siti Rahmah tahun 2024. Data tekanan darah dianalisis secara deskriptif dan komparatif menggunakan uji Mann-Whitney dan uji t tidak berpasangan sesuai distribusi data. Hasil penelitian menunjukkan bahwa lansia obesitas memiliki tekanan darah rata-rata dalam kisaran pra-hipertensi hingga hipertensi, dengan perempuan cenderung memiliki tekanan darah sistolik dan diastolik yang lebih tinggi dibandingkan laki-laki, meskipun perbedaan tersebut tidak signifikan secara statistik. Simpulan penelitian ini adalah lansia obesitas rentan mengalami tekanan darah tinggi tanpa perbedaan signifikan berdasarkan jenis kelamin, sehingga pemantauan dan intervensi gizi yang terfokus sangat diperlukan untuk pencegahan hipertensi pada kelompok ini. Kata Kunci: Lansia, Obesitas, Tekanan Darah, Hipertensi, Jenis Kelamin
Differences in Scube1 and Scube2 Gene Expression in Type II Diabetes Mellitus Patients with Dyslipidemia Saputri, Rahmi Agu; Ali, Hirowati; Tjong, Djong Hon; Anggraini, Debie; Yarni, Sisca Dwi
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.9875

Abstract

The Scube1 gene is expressed in atherosclerosis (plaque buildup in blood vessels), while Scube2 is expressed in DIT (Diffuse Intimal Thickening) which is used to describe diffuse thickening of the intima of blood vessels. This study aims to determine the differences in the expression of the scube1 gene in blood samples of type II DM patients with dyslipidemia and type II DM with non-dyslipidemia and differences in the expression of the scube2 gene in blood samples of type II DM patients with dyslipidemia and type II DM with non-dyslipidemia. With a comparative cross-sectional research method, the sample size of this study was determined based on the Lameshow hypothesis test formula which obtained 18 blood samples of type II DM with dyslipidemia, and 18 blood samples of type II DM with non-dyslipidemia. Blood samples of type II DM patients with dyslipidemia and blood samples of type II DM patients without dyslipidemia showed significantly different expression of the scube1 gene, with a p-value of 0.000. Similarly, blood samples from type II DM patients with dyslipidemia and those from type II DM patients without dyslipidemia showed a significant difference in scube2 gene expression (p = 0.001). Thus, it can be said that the expression of the Scube1 and Scube2 genes is significantly influenced by the complications of diabetes mellitus with dyslipidemia. This happens because it is believed that hyperglycemia in type II DM contributes to endothelial cell dysfunction, which occurs prior to blood vessel damage and results in progressively more severe blood vessel problems. Along with hyperglycemia, type II diabetes also results in dyslipidemia, an alteration in the normal lipid profile. Both dyslipidemia and hyperglycemia contribute to macrovascular and microvascular problems in type II diabetes.
Co-Authors Adelin, Prima Anggraini, Debie Djong Hon Tjong Hirowati Ali, Hirowati Yarni, Sisca Dwi