Article Per Year (5 Year)
p-Index From 2021 - 2026
0.751
P-Index
This Author published in this journals
All Journal Jurnal Sains dan Teknologi Jurnal Kesehatan Farmasi Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Roy Indrianto Bangar
Unknown Affiliation
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria Rosc) Sebagai Antidislipedemia terhadapTikus Putih (Rattus Norvegicus) Kevin Wijaya; Razoki Razoki; Roy Indrianto Bangar
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 4 (2025): Oktober : Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i4.2275

Abstract

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.  
Formulasi dan Uji Aktivitas Antibakteri Gel Minyak Atsiri Rimpang Lengkuas Merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes Astriani Natalia Br Ginting; Vera Estefania Kaban; Roy Indrianto Bangar; Daimah W. S. Harahap
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 1 (2025): Februari 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i1.4844

Abstract

Acne is a common dermatological condition caused by the bacterial infection of Propionibacterium acnes, leading to skin inflammation. Red galangal (Alpinia purpurata K. Schum) is known to exhibit antibacterial activity due to its essential oil content, flavonoids, and alkaloids. This study aims to formulate and evaluate the antibacterial activity of a gel preparation based on red galangal rhizome essential oil against Propionibacterium acnes. The research follows a laboratory experimental design, including the extraction of red galangal rhizome essential oil via maceration, formulation of the gel, and evaluation of its physical properties, such as pH, homogeneity, spreadability, and antibacterial activity using the disc diffusion method. The results demonstrated that the gel formulation met the required physicochemical standards, with a pH ranging from 6.4 to 6.8, good homogeneity, and an optimal spreadability of 5–7 cm. The antibacterial test revealed a significant inhibitory effect against Propionibacterium acnes, with an inhibition zone of up to 11.24 mm at a 15% concentration. These findings suggest that red galangal rhizome essential oil possesses strong antibacterial potential, making it a promising candidate for natural topical acne treatment. In conclusion, the red galangal essential oil gel exhibits favorable antibacterial activity against Propionibacterium acnes and has potential as an alternative acne treatment. Further studies are necessary to enhance the stability and efficacy of the formulation for optimal clinical applications.
Uji Aktivitas Ekstrak Etanol Daun Bandotan terhadap Penyembuhan Luka Sayat pada Tikus Putih Diabetes Melitus (Rattus norvegicus) Tya Bella Arthamarisi Simbolon; Muhammad Yunus; Roy Indrianto Bangar
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5143

Abstract

The wound healing process in individuals with diabetes mellitus is generally slower due to disruption of the inflammatory, proliferation, and regeneration mechanisms. Diabetics experience chronic metabolic disorders that impact immune cell function, blood circulation, and the regenerative capacity of fibroblasts and keratinocytes. Consequently, the wound healing process in diabetic patients is often more complex and takes longer. One approach to accelerating the wound healing process in this condition is the use of natural ingredients with anti-inflammatory, antimicrobial, and regenerative properties. One potential plant in this regard is the bandotan leaf (Ageratum conyzoides), which is known to contain active compounds such as flavonoids, alkaloids, and tannins that play a role in the wound healing process. This study was conducted to assess the effectiveness of bandotan leaf extract in accelerating wound healing in an animal model of diabetes mellitus. A total of 30 male white rats (Rattus norvegicus) that had been induced to become diabetic with streptozotocin were divided into six groups of five rats each. The groups included: a normal control group (healthy mice without diabetes), a negative control group (diabetic mice without treatment), a positive control group (given Metcovazin ointment as a standard), and three treatment groups that received topical application of bandotan leaf extract at graded concentrations of 10%, 15%, and 20%. A circular wound with a diameter of approximately 6 mm was made aseptically using a punch biopsy tool on the back of each mouse after being given ketamine anesthesia. Treatment was given daily for twelve consecutive days. The main parameters observed included daily measurements of the wound area to determine the rate of wound contraction.
MOLECULER DOCKING SENYAWA BIOAKTIF KULIT RARU (Cotylelobium melanoxylon) TERHADAP TARGET α-GLUKOSIDASE DAN α-AMILASE Josita Jenny Haryanti Hutagulung; Roy Indrianto Bangar
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3749

Abstract

Diabetes mellitus is a metabolic disease that affects the body’s ability to control blood glucose levels, making effective treatments necessary to reduce postprandial glucose increases. Flavonoid compounds from raru bark (Cotylelobium melanoxylon) have shown potential as inhibitors of carbohydrate-digesting enzymes, especially α-amylase and α-glucosidase. This study aimed to evaluate the antidiabetic potential of flavonoid compounds from raru bark using an in silico approach with molecular docking. Five flavonoid compounds—rutin, isoquercetin, quercetin, quercitrin, and isoquercitrin—were tested to examine their binding ability to the target enzymes. The results showed that rutin and isoquercetin had lower binding energy values than the standard ligand, indicating more stable interactions and stronger enzyme inhibition. These findings suggest that flavonoid compounds from raru bark may be developed as natural antidiabetic agents; however, further in vitro and in vivo studies are needed to confirm their safety and effectiveness.
Co-Authors Astriani Natalia Br Ginting Daimah W. S. Harahap Josita Jenny Haryanti Hutagulung Kevin Wijaya Muhammad Yunus Razoki Razoki Tya Bella Arthamarisi Simbolon Vera Estefania Kaban