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All Journal Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Teknologi Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan
Roy Indrianto Bangar
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria Rosc) Sebagai Antidislipedemia terhadapTikus Putih (Rattus Norvegicus) Kevin Wijaya; Razoki Razoki; Roy Indrianto Bangar
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 4 (2025): Oktober : Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i4.2275

Abstract

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.  
Hubungan Tingkat Pengetahuan Pasien Hipertansi Terhadap Kepatuhan Minum Obat Pada Pasien Rawat Jalan Di Rumah Sakit Royal Prima Adelia Pratiwi; Muhammad Yunus; Roy Indrianto Bangar
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3416

Abstract

Hypertension s a chronic condition with a high prevalence that can lead to cardiovascular complications if patients do not adhere to medication regimens and the medication adherence is on of the primary key to therapeutic success. However, low adherence rates remain a significant challenge, often linked to insufficient patient understanding. This study aimed to analyze the relationship between the level of knowledge of hypertensive patients and their medication adherence at Royal Prima Hospital. This research method employed a quantitative correlational design with a cross-sectional approach involving 78 outpatient respondents selected through purposive sampling. Demographic data were analyzed using the Chi-Square Test, while the relationship between the main variables was tested with Spearman Correlation. The results showed that the majority of respondents had a sufficient level of knowledge (52.6%) and moderate adherence (48.7%). The Spearman Correlation test yielded a coefficient value (rₛ) of 0.803 with p < 0.001, indicating a very strong and significant positive relationship between the level of knowledge and medication adherence. Conversely, the Chi-Square Test results showed no significant association between demographic characteristics and adherence. It is concluded that knowledge is a crucial determinant influencing treatment adherence among hypertensive patients.
Formulasi dan Uji Aktivitas Antibakteri Gel Minyak Atsiri Rimpang Lengkuas Merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes Astriani Natalia Br Ginting; Vera Estefania Kaban; Roy Indrianto Bangar; Daimah W. S. Harahap
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 1 (2025): Februari 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i1.4844

Abstract

Acne is a common dermatological condition caused by the bacterial infection of Propionibacterium acnes, leading to skin inflammation. Red galangal (Alpinia purpurata K. Schum) is known to exhibit antibacterial activity due to its essential oil content, flavonoids, and alkaloids. This study aims to formulate and evaluate the antibacterial activity of a gel preparation based on red galangal rhizome essential oil against Propionibacterium acnes. The research follows a laboratory experimental design, including the extraction of red galangal rhizome essential oil via maceration, formulation of the gel, and evaluation of its physical properties, such as pH, homogeneity, spreadability, and antibacterial activity using the disc diffusion method. The results demonstrated that the gel formulation met the required physicochemical standards, with a pH ranging from 6.4 to 6.8, good homogeneity, and an optimal spreadability of 5–7 cm. The antibacterial test revealed a significant inhibitory effect against Propionibacterium acnes, with an inhibition zone of up to 11.24 mm at a 15% concentration. These findings suggest that red galangal rhizome essential oil possesses strong antibacterial potential, making it a promising candidate for natural topical acne treatment. In conclusion, the red galangal essential oil gel exhibits favorable antibacterial activity against Propionibacterium acnes and has potential as an alternative acne treatment. Further studies are necessary to enhance the stability and efficacy of the formulation for optimal clinical applications.
Formulasi dan Evaluasi Sediaan Sabun Cair dari Umbi Porang (Amorphophallus muelleri Blume): Novia Agustini Irmasyari Siregar; Roy Indrianto Bangar; Erida Novriani
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7530

Abstract

Porang tuber (Amorphophallus muelleri Blume) is a potential natural resource that can be developed as an active ingredient in cosmetic preparations, particularly liquid soap. This study aimed to formulate and evaluate liquid soap containing porang tuber extract and to determine its physical quality characteristics. The tubers were extracted by maceration using 70% ethanol. Prior to extraction, simplicia characterization was performed, including determination of moisture content, water-soluble extractive, ethanol-soluble extractive, total ash, and acid-insoluble ash. Phytochemical screening was carried out to identify secondary metabolites. The extract was formulated into liquid soap preparations with concentrations of 3%, 5%, and 8%. The evaluation included organoleptic tests, pH measurement, foam height test, irritation test, and hedonic test. The results of simplicia characterization showed that all parameters met the requirements of the Herbal Pharmacopeia. Phytochemical screening indicated the presence of alkaloids, flavonoids, saponins, tannins, and triterpenoids. The formulated liquid soaps showed acceptable physical characteristics, pH values within the Indonesian National Standard range (8–11), adequate foam formation, and no skin irritation. Hedonic testing demonstrated that all formulations were acceptable to panelists. It can be concluded that porang tuber extract has potential as a natural active ingredient in liquid soap formulations.
Perbandingan Pelarut Etanol dan Gliserin pada Ekstrak Etanol Buah Bit (Beta vulgaris L.) terhadap Pertumbuhan Bakteri Staphylococcus aureus Tiani Nduru; Astriani Natalia Br Ginting; Roy Indrianto Bangar
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 5 No. 1 (2026): Januari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v5i1.7167

Abstract

Infectious diseases caused by Staphylococcus aureus remain a significant health concern globally, with increasing antibiotic resistance necessitating alternative antimicrobial agents. Beetroot (Beta vulgaris L.) contains bioactive compounds with potential antibacterial properties. This study investigated the antibacterial activity of beetroot ethanol extract against Staphylococcus aureus and compared the effects of ethanol and aqueous solvents in the extraction process. Beetroot simplicia was prepared and characterized according to standard protocols. Extraction was performed using 70% ethanol maceration method, yielding 20.29% extract. Phytochemical screening and thin-layer chromatography identified secondary metabolites. Antibacterial activity was evaluated using the Kirby-Bauer disc diffusion method at concentrations of 5%, 10%, and 15%, both with and without glycerin addition. Simplicia characterization met quality standards with moisture content of 0.25%. TLC analysis revealed alkaloids, flavonoids, terpenoids, steroids, saponins, and tannins. Beetroot ethanol extract demonstrated concentration-dependent antibacterial activity with inhibition zones of 8.1±0.87 mm (5%), 10.2±0.71 mm (10%), and 13.9±0.79 mm (15%). Glycerin-supplemented extracts showed comparable activity. Beetroot ethanol extract exhibits significant antibacterial activity against Staphylococcus aureus, supporting its potential as a natural antimicrobial agent for pharmaceutical applications.
Formulasi dan Evaluasi Sediaan Roll on Aromaterapi Minyak Atsiri Buah Andaliman (Zanthoxylum Acanthopodium Dc.) Novelia Zwi Dwinayanti Silaban; Roy Indrianto Bangar; Asyrun Alkhairi Lubis
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7535

Abstract

Andaliman (Zanthoxylum acanthopodium DC.) is an endemic spice from North Sumatra with significant therapeutic potential derived from its essential oils. Terpenoid compounds such as geranyl acetate, limonene, and citronellol in andaliman are recognized for their efficacy in aromatherapy to alleviate nausea and vomiting. This study aims to construct an aromatherapy roll-on formulation using andaliman fruit essential oil and to evaluate its physical characteristics and safety profile. The research employed a laboratory experimental method, utilizing the Stahl steam distillation technique for essential oil isolation. The preparations were formulated into three concentration variations: F0 (0%), F1 (5%), and F2 (10%). Evaluation parameters included organoleptic properties, homogeneity, viscosity, pH value, dermal irritation tests, and hedonic (preference) tests. The results demonstrated that all formulas maintained excellent physical stability and homogeneity. The pH values ranged from 5.52 to 6.06, which is considered safe as it aligns with the physiological pH of human skin (4.5–6.5). Irritation tests confirmed that the formulations did not trigger adverse skin reactions in respondents. According to the hedonic test, panelists showed high preference for aroma, texture, and comfort, although the scent longevity requires further optimization due to the volatile nature of the essential oil. Overall, the andaliman essential oil aromatherapy roll-on meets the physical quality and safety standards for topical preparations.
Perbandingan Ektrak Konvensional dengan Green Ektraksi Umbi Porang (Amorphophallus Muelleri) terhadap Aktivitas Antioksidan Pasti Marito Samosir; Roy Indrianto Bangar; Vera Estefania Kaban
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7536

Abstract

Porang tuber (Amorphophallus muelleri) contains various bioactive compounds with potential antioxidant activity, while extraction efficiency is strongly influenced by the applied method. This study aimed to compare conventional and environmentally friendly extraction techniques, including maceration, Soxhlet extraction, Microwave-Assisted Extraction (MAE), and Ultrasonic-Assisted Extraction (UAE), using 70% ethanol as the solvent. Antioxidant activity was evaluated using the DPPH radical scavenging assay and expressed as IC₅₀ values. The results showed that differences in extraction methods significantly affected antioxidant activity. Soxhlet extraction exhibited the highest antioxidant activity with the lowest IC₅₀ value (0.1788 µg/mL), followed by MAE (0.4312 µg/mL), maceration (0.6315 µg/mL), and UAE (0.6574 µg/mL). The superiority of the Soxhlet method is related to continuous solvent reflux and heat-assisted mass transfer, which enhance the release of antioxidant compounds. These findings confirm that porang tuber is a promising natural antioxidant source, with Soxhlet extraction identified as the most effective method under the applied experimental conditions for future development of functional food, nutraceutical, and pharmaceutical applications.
Kajian Potensi Etil Asetat Ekstrak Daun Andaliman : Total Fenol Flavonoid dan Aktivitas Uji Antioksidan Muhtamilatur Rahma; Roy Indrianto Bangar; Muhammad Yunus
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7537

Abstract

Andaliman leaves (Zanthoxylum acanthopodium DC.) are a traditional plant native to North Sumatra with potential as a natural antioxidant source due to their phenolic and flavonoid compounds. This study aimed to evaluate the antioxidant potential of the ethyl acetate extract of andaliman leaves based on total phenolic content, total flavonoid content, and antioxidant activity. Extraction was carried out using the maceration method with ethyl acetate as the solvent. Total flavonoid content was determined using the AlCl₃ method with quercetin as the standard, while total phenolic content was analyzed using the Folin– Ciocalteu method with gallic acid as the standard. Antioxidant activity was evaluated using the DPPH radical scavenging assay. The results showed that the ethyl acetate extract of andaliman leaves contained 73.40 mg QE/g extract of total flavonoids (7.3%) and 148.48 mg GAE/g extract of total phenolics. The antioxidant activity test yielded an IC₅₀ value of 4,2485 µg/mL, indicating that the extract exhibits very strong antioxidant activity. The high levels of phenolic and flavonoid compounds are believed to play an important role in the radical scavenging activity observed. Based on these findings, it can be concluded that the ethyl acetate extract of andaliman leaves has strong potential to be developed as a natural antioxidant source for applications in the pharmaceutical and health fields.
Co-Authors Adelia Pratiwi Astriani Natalia Br Ginting Asyrun Alkhairi Lubis Daimah W. S. Harahap Erida Novriani Kevin Wijaya Muhammad Yunus Muhtamilatur Rahma Novelia Zwi Dwinayanti Silaban Novia Agustini Irmasyari Siregar Pasti Marito Samosir Razoki Razoki Tiani Nduru Vera Estefania Kaban