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INFLUENCE OF DRUG COUNSELING ON COMPLIANCE OF PATIENTS WITH DYSLIPIDEMIA Elfia Neswita; Afriliani Br Sitepu; Razoki Razoki
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.14330

Masih rendahnya tingkat kepatuhan dalam meminum obat menyebabkan tingkat kesembuhan pasien rendah. Kebaruan dalam penelitian ini adalah pengaruh konseling obat terhadap kepatuhan pasien dislipidemia. Penelitian ini bertujuan untuk melihat apakah ada pengaruh dari pemberian konseling obat terhadap kepatuhan pasien dalam meminum obat sebelum dan sesudah diberi konseling obat. Metode penelitian ini menggunakan kuesioner Morisky MMAS-8 dan dilakukan secara prospektif quasi-eksperimental secara one group pretest-posttest design dan data dianalisis dengan Paired-sample T-test, regresi linier sederhana menggunakan SPSS versi 28. Hasil penelitian menunjukkan adanya pengaruh konseling obat pada pasien Dislipidemia sebelum dan sesudah diberi konseling obat dengan nilai signifikansi sebesar 0,01 dengan arti bahwa tingkat kepercayaan pada penelitian ini sebesar 99%. Kesimpulan penelitian ini diperlukan peranan farmasi dalam memberikan konseling obat di setiap unit kesehatan.Kata Kunci: Kepatuhan; Pasien dislipidemia; Konseling obat AbstractThe low level of adherence to taking medication causes the patient's recovery rate to be low. This study aims to be low. The novelty in this study is the effect of drug counseling on the adherence of dyslipidemic patients. This study aims to see whether there is an effect of counseling on patient compliance in taking medication before and before being given drug counseling. This study aims to see whether there is an effect of giving drug counseling on treatment adherence in people taking medication before and after being given drug counseling. This research method uses the Morisky MMAS-8 questionnaire and is carried out in a prosective quasi-experimental one group pretest-posttest design, with data analyzed using the Paired Sample T-Test and Simple Linear Regression in SPSS version 28. The results showed that there was an effect of drug counseling on dyslipidemic patients before and after being counseled, with a significance value 0.01, which means that the confidence level in this study is 99%. The conclusion of this study is that the role of pharmacy is needed in providing drug counseling in every health unit.Keywords: Treatment Adherence; Dyslipidemia; Drug Counseling

ADMINISTRATIVE, PHARMACEUTIC AND CLINICAL STUDY OF ANTIBOTIC DRUG PRESCRIPTIONS FOR THE PERIOD OCTOBER-DECEMBER 2020 AT ONE OF THE IN MEDAN CITY Enjelina Br Hutapea; Elfia Neswita; Razoki Razoki
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 6, No 3 (2022): OKTOBER: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMU
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v6i3.15101

Abstrak Banyaknya kasus kesalahan pengobatan yang terjadi dalam tiap proses pengobatan, baik dalam proses peresepan, pembacaan resep, penyiapan hingga penyerahan obat maupun dalam proses penggunaan obat berakibat pada pelayanan obat yang tidak tepat dan membahayakan pasien dimana hal tersebut semestinya dapat dicegah. Kebaruan dalam penelitian ini meneliti tentang kajian administratif, farmasetis dan klinis resep antibiotik periode oktober – desember 2020 di salah satu apotek di kota medan. Tujuan dari penelitian ini adalah melihat apakah ada terdapat kesesuaian kelengkapan administratif, farmasetis dan klinis pada peresepan di salah satu Apotek di Kota Medan yang memenuhi PMK No 73 Tahun 2016. Metode penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan cross sectiona. Pengumpulan data dilakukan secara retrospektif yaitu data yang berasal dari resep antibiotik periode Oktober -desember 2020 di salah satu apotek di Kota Medan. Hasil dari penelitian ini adalah dari 120 resep yang ada di salah satu apotek di kota medan dari aspek kajian administratif dan klinis tersebut 100% yang tidak memenuhi kriteria. Sedangkan dari aspek kajian farmasetis yang tidak memenuhi sebanyak 42 % dari 120 lembar resep , Semua lembar resep memiliki interaksi obat yang merugikan; ketidak tepatan dosis antibiotik; stabilitas sediaan dan kompatibilitas sediaan yang tidak sesuai. Kesimpulanya yaitu sebanyak 100 % aspek administratif dan kajian klinis dari resep antibiotik periode oktober – desember 2020 di salah satu apotek di kota medan yang tidak meemenuhi PMK No .73 Tahun 2016 .Kata kunci: Kajian Administratif, Farmasetis, Klinis, Peresepan, Antibiotik AbstractThe number of cases of medication errors that occur in each treatment process, both in the prescribing process, reading prescriptions, preparation to delivery of drugs as well as in the process of using drugs, results in inappropriate drug services and endangering patients where this should be prevented. The novelty in this study examined administrative, pharmaceutic and clinical studies of antibiotic prescriptions for the period October – December 2020 at one of the pharmacies in medan city.The purpose of this study was to see whether there was a conformity of administrative, pharmaceutical and clinical completeness in prescribing at one of the pharmacies in Medan City that met PMK No. 73 of 2016. This research method used a descriptive research method with a cross sectional approach. Data collection was carried out retrospectively, namely data from antibiotic prescriptions for the period October-December 2020 at one of the pharmacies in Medan City. The results of this study were that of the 120 prescriptions in one of the pharmacies in Medan City, from the administrative and clinical aspects of the study, 100% did not meet the criteria. Meanwhile, from the aspect of the pharmaceutical study that did not meet as many as 42% of the 120 prescription sheets, all prescription sheets had adverse drug interactions; inappropriate dose of antibiotics; the stability of the preparation and the compatibility of the inappropriate preparations. The conclusion is that 100% of the administrative aspects and clinical studies of prescribing antibiotics for the period october - december 2020 in one of the pharmacies in the city of Medan do not comply with PMK No. 73 of 2016.Keywords: Arthritis; Administrative, Pharmaceutic, Clinical, Prescribing, Antibiotic Studies

Evaluasi Penggunaan Antibiotik Pada Pasien Anak Rawat Inap Rsu Mitra Sejati Nerly Juli Pranita Simanjuntak; Simran Kaur; Razoki Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3103

Inappropriate use of antibiotics can lead to resistance and other negative impacts, especially in vulnerable groups such as children. Evaluation of antibiotic use is very important to ensure the effectiveness of therapy and avoid resistance. This study aims to evaluate the use of antibiotics in pediatric patients hospitalized at Mitra Sejati Hospital using the ATC/DDD method and 90% DU analysis. This study used a retrospective approach from the medical records of pediatric patients aged 1-18 years during October 2024 to February 2025. Based on the results of the study, it was found that the most widely used type of antibiotics was ceftriaxone (5,70 DDD/100 patient-days). While based on the results of 90% DU analysis, the most commonly prescribed antibiotics were ceftriaxone, cefixime syrup and tablet and azithromycin. These results indicate that most of antibiotic use at Mitra Sejati Hospital is included in the 90% DU segment, but routine monitoring is still needed to ensure the appropriateness of its use.

Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) Cut Inssy Mulun; Razoki Razoki; Erida Novriani
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5659

Background: Chinese betel (Peperomia pellucida L.) is an herbal plant rich in bioactive compounds such as flavonoids, alkaloids, and tannins that have the potential to be antioxidants, antimicrobials, and antidiabetics. However, the stability and absorption of its active compounds in the body is still a challenge. Microencapsulation technology and a floating drug delivery sistem (FDDS) can improve the effectiveness and stability of herbal preparations. Objective: This study aims to formulate and evaluate floating microencapsulation preparations containing Chinese betel herb ethanol extract using modern drug delivery technology. Methods: Ethanol extracts were obtained by maceration method and formulated by ionic gelation technique using a combination of sodium alginate and chitosan at three concentration variations (0.25%, 0.5%, and 0.75%). The evaluation included morphological analysis with SEM, ex vivo buoyancy test on the stomach of Wistar rats, determination of moisture content, and physical stability test using the cycling test method. Results: Microencapsulation with a concentration of 0.75% showed the most compact and delicate morphology, the lowest moisture content (0.64%), and the best physical stability. All formulations are capable of floating, with the longest buoyancy time at a concentration of 0.25% for 8 hours. There were no significant physical changes after six cycles of extreme temperatures. Conclusion: Microencapsulation preparations of Chinese betel ethanol extract in a natural polymer-based floating system show good stability and potential as an innovative herbal formulation to extend retention time in the stomach.

Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria Rosc) Sebagai Antidislipedemia terhadapTikus Putih (Rattus Norvegicus) Kevin Wijaya; Razoki Razoki; Roy Indrianto Bangar
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 4 (2025): Oktober : Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i4.2275

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.

Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Daun Salam (Syzygium polyanthum) Sebagai Antidislipidemia Terhadap Tikus Putih Stefanus Rio Pendamenta Tarigan; Razoki Razoki; Erida Novriani
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 4 (2025): Oktober : Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i4.2276

Dyslipidemia is a lipid metabolism disorder characterized by elevated levels of total cholesterol, triglycerides, and low-density lipoprotein (LDL) accompanied by decreased levels of high-density lipoprotein (HDL). This condition is a major risk factor for atherosclerosis, coronary heart disease, and stroke. One plant with potential as an antidyslipidemic agent is bay leaves (Syzygium polyanthum). These leaves are known to contain active compounds such as flavonoids, saponins, tannins, alkaloids, and polyphenols that have antioxidant and hypolipidemic activities. The potential of natural compounds from medicinal plants to reduce blood cholesterol levels has gained significant attention in recent years. This study aims to evaluate the effectiveness of microencapsulated ethanol extract of bay leaves in reducing total cholesterol levels in white rats (Rattus norvegicus) induced by a high-cholesterol diet. The experimental study design employed was a laboratory-based true experimental method with a post-test control group design. A total of 25 male rats were used and divided into six groups: normal control, negative control (high cholesterol diet without therapy), positive control (simvastatin), and three groups treated with bay leaf extract microencapsulates at doses of 0.25%, 0.5%, and 0.75%. The treatment was given for 14 days, then total cholesterol levels were measured using an enzymatic method. The results showed that the group with a dose of 0.75% experienced the highest decrease in total cholesterol levels, namely -70 mg/dL, greater than the simvastatin group (-49 mg/dL). Statistical analysis using One Way ANOVA showed a significant difference compared to the negative control (p < 0.001). These findings indicate that the 0.75% dose of microencapsulated Syzygium polyanthum extract demonstrated an effect equal to or greater than simvastatin. Thus, it can be concluded that bay leaf ethanol extract microencapsulates are effective in reducing total cholesterol levels in hypercholesterolemic rats. This suggests that Syzygium polyanthum microencapsulation has the potential to be developed as an alternative phytotherapy for cholesterol reduction.

Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Daun Pepaya (Carica papaya L.) sebagai Antidislipidemia terhadap Tikus Putih Devin Rio Alvaro; Razoki Razoki; Muhammad Yunus
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 2 No. 3 (2025): September : Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v2i3.2273

Dyslipidemia is a health problem characterized by impaired fat metabolism in the body, characterized by changes in blood lipid levels, either increasing or decreasing. This condition is generally seen through increased levels of total cholesterol, low-density lipoprotein (LDL), triglycerides, and decreased levels of high-density lipoprotein (HDL). This imbalance in the lipid profile, if persisted over the long term, has the potential to accelerate the formation of atherosclerotic plaque on artery walls, which can lead to cardiovascular disease. This study aims to determine the effectiveness of papaya leaf (Carica papaya L.) ethanol extract microcapsules in reducing cholesterol levels in white rats induced by a high-fat diet. The high-fat diet is formulated from a mixture of beef fat, eggs, and lard to increase cholesterol levels in a controlled manner. After the induction phase, the rats were divided into six treatment groups: a negative control group, a positive control group (simvastatin 0.36 mg), and three treatment groups with doses of papaya leaf ethanol extract microcapsules of 0.25%, 0.50%, and 0.75%. The treatment was given orally for 14 consecutive days. Total cholesterol levels were measured before and after treatment to evaluate the effectiveness of the intervention. The results showed that administration of papaya leaf extract microcapsules significantly reduced cholesterol levels. The 0.50% dose provided the most optimal effect, with a reduction reaching 77 mg/dL, greater than the simvastatin group. However, increasing the dose to 0.75% did not show a significant additional reduction effect, indicating an optimal dose-response point. Therefore, the 0.50% concentration can be considered the most effective dose and has the potential to be developed as an alternative natural cholesterol-lowering therapy. These findings also strengthen the potential use of papaya leaves as a bioactive source to support efforts to prevent and control dyslipidemia.

Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) Sebagai Antidislipidemia terhadap Tikus Putih Ricky Martino; Razoki Razoki; Muhammad Yunus
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 2 No. 3 (2025): September : Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v2i3.2274

Dyslipidemia is a lipid metabolism disorder characterized by an increase or decrease in blood plasma fat levels. This condition includes high levels of total cholesterol, low-density lipoprotein (LDL), and triglycerides, as well as decreased levels of high-density lipoprotein (HDL). In general, dyslipidemia is divided into two types: primary, which is influenced by genetic factors, and secondary, which is caused by other diseases or an unhealthy lifestyle. Dyslipidemia is one of the major risk factors for cardiovascular disease, making its prevention and treatment very important. In this study, male white mice were used and induced with a high-fat diet to trigger dyslipidemia. The test animals were then divided into six groups: a negative control, a positive control (given simvastatin at a dose of 0.36 mL/day), and three treatment groups with microcapsules of Chinese betel leaf herb ethanol extract (EEHSC) at concentrations of 0.25%, 0.5%, and 0.75%. The treatment was administered orally for 14 days. Cholesterol levels were measured before and after treatment using a digital cholesterol tester and laboratory analysis to ensure more accurate results. The results showed a decrease in cholesterol levels with varying percentages in each group. The negative control decreased by 24.8%, the positive control by 36.1%, the 0.25% EEHSC by 24.1%, the 0.5% EEHSC by 34.7%, and the 0.75% EEHSC by 45.5%. This indicates that the 0.5% EEHSC treatment produced cholesterol reductions almost comparable to simvastatin. Interestingly, the highest effect was observed in the 0.75% group, indicating a dose-dependent response. In contrast, the 0.25% concentration only produced a less than optimal effect. Thus, microcapsules of ethanol extract of the Chinese betel leaf herb have potential as an alternative agent for lowering cholesterol levels, particularly in dyslipidemia. These findings suggest that natural-based therapies could complement conventional treatments in managing lipid disorders.

Uji Aktivitas Antioksidan Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) dengan Metode DPPH Jecika Stefany Br Tumanggor; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6142

Free radicals are reactive compounds that can cause damage to cells, enzymes, lipids, and even DNA, thus triggering various degenerative diseases. Antioxidants neutralize free radicals and prevent oxidative damage. Chinese betel herb (Peperomia pellucida L.) is known to contain phenol and flavonoid secondary metabolite compounds that act as natural antioxidants. This study aims to test the antioxidant activity of ethanol extract of Chinese betel herb with DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was done by maceration method using 80% ethanol solvent. Antioxidant activity was tested by reacting the extract against DPPH solution and measuring the absorbance using UV-Vis spectrophotometry. The results showed an IC₅₀ value of 32.97 ppm, which is classified as very strong antioxidant activity. These results indicate that ethanol extract of Chinese betel herb has great potential as a source of natural antioxidants.

Uji Aktivitas Antioksidan Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode DPPH Anggun Pratiwi; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6231

Oxidative stress is a condition resulting from an imbalance between free radicals and the body's antioxidant system, which can damage cells and trigger degenerative diseases such as diabetes, cancer, atherosclerosis and heart disease. Antioxidants play an important role in neutralizing free radicals to prevent cell damage. Papaya leaves (Carica papaya L.) are known to contain bioactive compounds that have potential as a source of natural antioxidants. This study aims to test the antioxidant activity of papaya leaf ethanol extract using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, with quercetin as a comparator. Extraction was done by maceration using 80% ethanol. Antioxidant activity was measured based on the decrease in absorbance of DPPH solution at a wavelength of 517 nm using UV-Vis spectrophotometer. The results showed that papaya leaf extract had strong antioxidant activity with IC₅₀ value of 21.35 ppm, while quercetin was 4.84 ppm. Thus, the ethanol extract of papaya leaves showed high potential as an effective natural antioxidant.

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