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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
., Legiran
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Medicine & Pharmacology

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Correlation of Alpha-Fetoprotein Levels with ThreePhase Contrast CT-Scan Finding in Hepatocellular Carcinoma Patients at Dr. Mohammad Hoesin General Hospital Palembangin 2022 – 2023 Nainggolan, Florence Tania; Suprianto, Imam; ., Legiran
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, August, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025114-119

Abstract

Background: Hepatocellular carcinoma (HCC) is the primary liver tumor, accounting for 90% of liver tumor cases. Currently, laboratory tests are needed to monitor tumor progression, predict prognosis, and determine appropriate therapy without radiological examinations, one of which is Alpha-Fetoprotein (AFP). This study aims to determine the correlation between AFP levels and three-phase contrast CT-Scan findings in HCC patients at Dr. Mohammad Hoesin General Hospital Palembang.Methods: This was a cross-sectional design observational analytic study, using secondary data from medical records that included patient demographics, AFP, ALT, AST, direct bilirubin, indirect bilirubin, and three-phase contrast CT-Scan findings covering nodule size, nodule number, and metastasis in HCC patients treated at Dr. Mohammad Hoesin General Hospital Palembang from January 2022 – December 2023, meeting inclusion and exclusion criteria. Data were analyzed using SPSS version 22. Results: A total of 71 samples met the inclusion and exclusion criteria. Univariate analysis showed the majority were male (83.1%), aged 50–59 years (35.2%), with elevated ALT (59.2%), AST (94.4%), direct bilirubin (91.8%), indirect bilirubin (54.1%), AFP ≥200 ng/mL (77.5%), nodule size ≥30 mm (87.3%), multiple nodules (67.6%), and no extrahepatic metastasis (74.6%). Bivariate analysis showed a significant correlation between AFP levels and nodule size on three-phase contrast CT-Scan (p-value = 0.031).Conclusion: There is a significant correlation between AFP levels and three-phase contrast CT-Scan findings in HCC patients at Dr. Mohammad Hoesin General Hospital Palembang in 2022–2023.
Correlation of Neutrophil-Lymphocyte Ratio, Alpha-Fetoprotein, and PIVKA-II with Staging of HCC Related HBV at Dr. Mohammad Hoesin Hospital, Palembang Rahmayani, Febry; Suyata, Suyata; ., Legiran
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025219-227

Abstract

Background: The staging of Hepatocellular carcinoma (HCC) requires evaluating the tumor size and number, liver function, physical performance, tumor invasion, extrahepatic metastasis, and clinical symptoms. Biomarkers such as neutrophil-lymphocyte ratio (NLR), alpha-fetoprotein (AFP), and protein induced by the absence of vitamin K or antagonist-II (PIVKA-II) have been identified as valuable diagnostic and prognostic tools for HCC. This study aims to investigate the correlation between NLR, AFP, and PIVKA-II and HCC stages.Methods: This observational study was conducted at the Department of Internal Medicine, Dr. Mohammad Hoesin Hospital, Palembang, from April to July 2024. HCC stages were classified using the Barcelona Clinic Liver Cancer (BCLC) system. NLR, AFP, and PIVKA-II levels were measured using  ELISA method. Data were analyzed susing one-way ANOVA or the Kruskal-Wallis test.Results: A total of 38 patients with HCC who met the inclusion criteria were included in the study. There was a weak positive correlation between NLR and HCC stage (r = 0.334; p = 0.040), a moderate positive correlation between AFP and HCC stage (r = 0.499; p = 0.001), and a strong positive correlation between PIVKA-II and HCC stage (r = 0.797; p = 0.000). PIVKA-II and AFP were found to have a significant sequential effect on the BCLC stage.Conclusion: PIVKA-II and AFP are significant indicators for assessing BCLC stages, offering valuable support for the diagnosis and management of HCC.
Co-Authors Nainggolan, Florence Tania Rahmayani, Febry Suprianto, Imam Suyata Suyata