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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Suprianto, Imam
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Public Health

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THE ASSOCIATION BETWEEN BODY MASS INDEX (BMI) AND GASTROESOPHAGEAL REFLUX DISEASE (GERD) INCIDENCE AMONG VISITORS AT THE GASTROENTEROLOGY CLINIC OF RSUP DR. MOHAMMAD HOESIN PALEMBANG Zuhdi, Kgs. Muhammad; Astoni, Muhamad Ayus; Rasyid, Riana Sari Puspita; Suprianto, Imam; Prasasty, Gita Dwi
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.626

Abstract

This study aimed to determine the association between BMI and the incidence of GERD in visitors to the Gastroclinic of RSUP Dr. Mohammad Hoesin Palembang. A total of 153 samples met the eligibility requirements, this study used a random sampling technique and collected primary data through a questionnaire instrument. Data were analyzed using SPSS Statistic V27 in univariate, bivariate (chi-square test) and multivariate (logistic regression enter method) analysis. The majority of GERD patients were aged 36-65 years (46.7%), male sex (46.2%) and BMI in the obese category (65.9%). The results of this research showed no significant association among age and sex in the incidence of GERD, but there was a significant association between BMI on the incidence of GERD (p=0.003) thus being the most significant variable in this research (p=0.012). In conclusion, there is a significant association between BMI and the incidence of GERD while there is no significant association among age and sex in the incidence of GERD.
Correlation of Alpha-Fetoprotein Levels with ThreePhase Contrast CT-Scan Finding in Hepatocellular Carcinoma Patients at Dr. Mohammad Hoesin General Hospital Palembangin 2022 – 2023 Nainggolan, Florence Tania; Suprianto, Imam; ., Legiran
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, August, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025114-119

Abstract

Background: Hepatocellular carcinoma (HCC) is the primary liver tumor, accounting for 90% of liver tumor cases. Currently, laboratory tests are needed to monitor tumor progression, predict prognosis, and determine appropriate therapy without radiological examinations, one of which is Alpha-Fetoprotein (AFP). This study aims to determine the correlation between AFP levels and three-phase contrast CT-Scan findings in HCC patients at Dr. Mohammad Hoesin General Hospital Palembang.Methods: This was a cross-sectional design observational analytic study, using secondary data from medical records that included patient demographics, AFP, ALT, AST, direct bilirubin, indirect bilirubin, and three-phase contrast CT-Scan findings covering nodule size, nodule number, and metastasis in HCC patients treated at Dr. Mohammad Hoesin General Hospital Palembang from January 2022 – December 2023, meeting inclusion and exclusion criteria. Data were analyzed using SPSS version 22. Results: A total of 71 samples met the inclusion and exclusion criteria. Univariate analysis showed the majority were male (83.1%), aged 50–59 years (35.2%), with elevated ALT (59.2%), AST (94.4%), direct bilirubin (91.8%), indirect bilirubin (54.1%), AFP ≥200 ng/mL (77.5%), nodule size ≥30 mm (87.3%), multiple nodules (67.6%), and no extrahepatic metastasis (74.6%). Bivariate analysis showed a significant correlation between AFP levels and nodule size on three-phase contrast CT-Scan (p-value = 0.031).Conclusion: There is a significant correlation between AFP levels and three-phase contrast CT-Scan findings in HCC patients at Dr. Mohammad Hoesin General Hospital Palembang in 2022–2023.
Correlation Between Serum Soluble PD-1, CD8+ , CD4+ T Lymphocyte Counts and Liver Stiffness in Antiviral-Naïve Chronic Hepatitis B Patients Aliana, Rizki; Yuristo, Eddy; Legiran, Legiran; Suprianto, Imam; Busro, Vidi Orba; Astoni, Muhamad Ayus; Sya'roni, Anjab Akmal; Suyata, Suyata; Zaky, Samy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202610-18

Abstract

Background: Chronic hepatitis B (CHB) disease is a major global health problem with a high burden in Asia, including Indonesia. Liver stiffness measurement by transient elastography is a non-invasive key tool to assess fibrosis severity. The immune response in CHB involves T cell exhaustion marked by elevated soluble PD-1 (sPD-1) and changes in T lymphocyte subsets, which may influence fibrosis progression. This study aimed to assess the correlation between serum sPD-1, CD4+, and CD8+ T lymphocyte counts and liver stiffness in antiviral-naïve CHB patients.Methods: A cross-sectional study was conducted among 60 untreated CHB patients at Mohammad Hoesin Hospital, Palembang, Indonesia. The sPD-1 was measured by ELISA, while CD4+ and CD8+ T cell counts were determined via flow cytometry. Liver stiffness was assessed by transient elastography. Spearman correlation and multivariate linear regression were used to analyze associations between immune markers and liver stiffness.Results: Serum sPD-1 showed a significant positive correlation with liver stiffness (r = 0.481, p 0.001), while CD8+ T lymphocyte count was negatively correlated (r = –0.553, p 0.001). CD4+ T lymphocyte count showed no significant bivariate correlation (r = –0.189, p = 0.149). In the multivariate analysis, sPD-1 (β = 0.050, p 0.001), CD4+ T cells (β = –0.018, p = 0.001), and AST (β = 0.061, p = 0.005) were independent predictors of liver stiffness.Conclusion: Serum sPD-1 and CD4+ T-lymphocyte count are independently associated with liver stiffness in antiviral-naïve CHB patients. These findings suggested the involvement of immune exhaustion and liver injury in HBV-related fibrosis.
Co-Authors ., Legiran Aliana, Rizki Busro, Vidi Orba Gita Dwi Prasasty Legiran Legiran Muhamad Ayus Astoni Nainggolan, Florence Tania Rasyid, Riana Sari Puspita Suyata Suyata Sya'roni, Anjab Akmal Yuristo, Eddy Zaky, Samy Zuhdi, Kgs. Muhammad