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All Journal Jurnal Biologi Tropis Sehat Rakyat: Jurnal Kesehatan Masyarakat
Azis, Asyari Al Hutama
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation and Evaluation of Red Betel Leaf (Piper crocatum L) Ethanol Extract 96% in Anti-Acne Cream Pratiwi, Yani; Azis, Asyari Al Hutama; Dilla, Nurfarah
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9570

Abstract

Acne (Acne vulgaris) is a common skin problem experienced, especially by teenagers and young adults, which can lower self-esteem. One causes is bacteria Propionibacterium acnes and Staphylococcus epidermidis. Red betel leaves (Piper crocatum L) are known to contain active compounds such as flavonoid, tannins, alkaloid, and essential oil that effective as antibacterial and anti-inflammatory agents. The aim of this study is to formulate and evaluate a topical cream containing a 96% ethanol extract of red betel leaves (Piper crocatum L.) as an anti-acne preparation. This study employed a laboratory experimental approach, formulating an oil-in-water (O/W) type cream by varying the concentrations of the emulsifiers stearic acid and triethanolamine (TEA). The physical properties of the cream were assessed through organoleptic evaluation, homogeneity testing, pH measurement, spreadability, adhesion, viscosity, cream type identification, and mechanical stability testing. The results that formula IV with an extract concentration of 12.5%, stearic acid 17%, and TEA 3.5% produces the most optimal results, with stable physical characteristics, homogeneous, and meeting topical cosmetic standards. Thus, 96% ethanol extract cream of red betel leaf has potential to be used as alternative treatment for acne based on natural ingredients.
Implementasi Manajemen Farmasi di Apotek: Analisis Kesesuaian Penyimpanan Obat Berdasarkan Standar Pelayanan Kefarmasian Irfan Kurniawan; Yani Pratiwi; Azis, Asyari Al Hutama
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 4 No. 4 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v4i4.5707

Abstract

Healthcare facilities play an essential role, not only as a place for pharmacists to carry out pharmacy practice but also in ensuring the quality of medicines provided to the community. Therefore, the aspect of drug storage is a crucial factor that requires careful attention. If not managed in accordance with established standards, it may decrease drug effectiveness, accelerate deterioration, cause dispensing errors, and result in undetected drugs that are nearing or have already passed their expiration date. The objective of this study was to identify drug storage management in APP, APT, and APSJ in Makassar City and to analyze the level of conformity of these storage systems with Pharmaceutical Service Standards No. 73 of 2016. Data were collected through direct observation using a checklist and interviews. This study employed an observational method with a descriptive quantitative and evaluative approach, which involved observing ongoing activities and comparing them with the regulations related to pharmaceutical service standards, particularly regarding drug storage management. The collected data were analyzed using descriptive assessment categories, where scores of 81–100% were classified as “very good,” 61–80% as “good,” 41–60% as “fair,” 21–40% as “poor,” and 0–20% as “very poor.” Based on the observations, the drug storage systems in APP, APT, and APSJ in Makassar City achieved scores of 90.48%, 90.91%, and 90.91%, respectively. These results fall into the “very good” category, indicating compliance with the Technical Guidelines for Pharmaceutical Services issued in 2019.
Antifungal Effectiveness Test of Gleichenia linearis Burm. (Farm) Leaf Extract on Candida albicans Fungi Azis, Asyari Al Hutama; Pratiwi, Yani; Nurfirawati, Nurfirawati
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10781

Abstract

The fern leaf (Gleichenia linearis Burm.) is a species of fern known to have potential as an agent that inhibits fungal growth. This study aims to test the antifungal effectiveness of fern leaf extract against the growth of Candida albicans and determine the most effective concentration. The extract was obtained through 70% ethanol maceration from 500 g of dried leaves, then formulated in concentrations of 5%, 10%, and 20%. Disc diffusion tests were carried out on SDA media, with 10 μg ketoconazole as a positive control and 70% ethanol as a negative control. The results showed an average inhibition zone of 4.66 mm (5%), 6.91 mm (10%), and 10.83 mm (20%), while the positive control was 18.54 mm and the negative control showed no inhibition. The Kruskal-Wallis test (Sig.) <0.05 was used as a reference resulting in a p value = 0.009, indicating a significant difference between groups. The results of phytochemical screening showed the presence of alkaloids, flavonoids, saponins, tannins, phenolics, and terpenoids. In conclusion, fern leaf extract is effective in inhibiting the growth of Candida albicans, with a concentration of 20% being the most effective.
Co-Authors Dilla, Nurfarah Irfan Kurniawan Nurfirawati, Nurfirawati Pratiwi, Yani Yani Pratiwi