This research aims to analyze the application of Islamic values in sharia entrepreneurship skills and their impact on economic growth, especially in the MSME sector in Medan City. The research method used is qualitative with a descriptive approach, where data was obtained through surveys and interviews with five business actors in the fashion sector in Medan City. The results of the study show that the application of sharia principles such as honesty, discipline, independence, commitment, and social usefulness plays a significant role in building consumer trust, increasing loyalty, and strengthening business resilience. In addition, Islamic values also encourage innovation and productivity, as seen in adaptive marketing strategies and business management that is free from riba, gharar, and maysir. The findings of this study reinforce the theory that sharia entrepreneurship is not only oriented towards material gains, but also creates positive social impact through community empowerment and ethical business practices. The implication of this research is the importance of the support of the government, Islamic financial institutions, and educational institutions in developing training and mentoring programs to strengthen the sharia-based entrepreneurship ecosystem. Thus, sharia entrepreneurship can be a strategic solution in facing global economic challenges, while encouraging inclusive and sustainable economic growth in Indonesia.