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Rosida, Waki'atil
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Mathematics Physics Other

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Journal : Life Science and Biotechnology

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In Silico Biological Activity Prediction of Bioactive Compounds from Dumortiera hirsuta (Sw.) Nees. Using Way2Drug PASS Online Farhan, Abdillah Maulana; Rosida, Waki'atil; Ulum, Fuad Bahrul
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

The liverwort Dumortiera hirsuta (Sw.) Nees. is recognized as a potential source of pharmacologically active metabolites. Bioactive compounds from D. hirsuta have been previously reported through in vitro metabolomic analyses using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS). In this study, the biological activities of the GC-MS-identified metabolites were evaluated in silico using the Way2Drug PASS Online platform. The results indicated that ten metabolites from D. hirsuta exhibit medicinal potential, with Pa values greater than 0.7, suggesting a high probability of biological activity. Among these compounds, stigmasterol (Pa = 0.970) and lathosterol (Pa = 0.960) demonstrated the strongest antihypercholesterolemic potential, indicating their role as natural agents for reducing cholesterol levels. These findings highlight the pharmacological potential of D. hirsuta metabolites and warrant further validation through in vitro cholesterol-lowering assays to confirm their predicted activities.
Co-Authors Dwi Setyati Dwinianti, Edia Farhan, Abdillah Maulana Fuad Bahrul Ulum Mustafidah, Qori'atul Su'udi, Mukhamad