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All Journal HAYATI Journal of Biosciences Jurnal Penelitian Sains Jurnal Pengabdian West Science Life Science and Biotechnology
Farhan, Abdillah Maulana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Immunology & microbiology Mathematics Physics Public Health Social Sciences

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Marchantia polymorpha : Studi Profil dan Kandungan Senyawa Bioaktif Potensial sebagai Obat di Masa Mendatang Farhan, Abdillah Maulana; Masayu, Muhammad Zulfikar Arian; Azizah, Alya Najwa; Risqi, Alexandria Zazila; Shodiq, Abdulloh Hasan; Shodiq, Muhammad Husein
Jurnal Penelitian Sains Vol 27, No 2 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i2.1101

Abstract

Marchantia polymorpha is one type of liverwort thallus. This liverwort has three subspecies: M. polymorpha subsp. polymorpha, M. polymorpha subsp. ruderalis, and M. polymorpha subsp. montivagans. These three subspecies exhibit different morphologies and have their own characteristics. M. polymorpha subsp. polymorpha is characterized by a thick black line running down the center of the thallus to the tip, while M. polymorpha subsp. ruderalis has a broken central line on the thallus, and M. polymorpha subsp. montivagans has no central line on its thallus. M. polymorpha contains bioactive compounds that have potential medicinal properties. Analysis using GC-MS indicates that there are 10 dominant compounds in this liverwort, with 8 of them being potentially beneficial for health, acting as antimicrobials, anticancer agents, anti-inflammatory agents, and having other biological activities. The aim of this study is to explore further information regarding the profile and bioactive compound content of M. polymorpha using a literature or secondary data approach. The benefits of this study are to advance the stages of primary research and to provide an overview of the morphology, distribution, life cycle of the liverwort, the content of its compounds, and its potential as a medicine in the future. 
Phytochemistry Profile and Antioxidant Activity of Dumortiera hirsuta (Sw.) Nees from Gumitir, East Java Farhan, Abdillah Maulana; Setyati, Dwi; Gilani, Noor Azizah; Su’udi, Mukhamad; Ulum, Fuad Bahrul
HAYATI Journal of Biosciences Vol. 32 No. 6 (2025): November 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.6.1643-1653

Abstract

Dumortiera hirsuta, a thalloid liverwort, predominantly grows on the ground floor of coffee plantations in Gumitir, Jember District, East Java, and is known for its rich phytochemical content. This study aimed to comprehensively profile the volatile and non-volatile compounds present in the methanol extract of D. hirsuta and evaluate its antioxidant activity. The thallus was macerated using 96% methanol (1:10 ratio), followed by analysis using Gas Chromatography–Mass Spectrometry (GC–MS) and Liquid Chromatography–Mass Spectrometry Quadrupole Time-of-Flight (LC–MS QTOF). GC–MS identified 37 volatile compounds, with terpenes (29%), phenols (21%), and fatty acids (13%) as dominant classes. Several potent antioxidant sesquiterpenoids, including caryophyllene, guaiene, and aromadendrene derivatives, were notably abundant, along with unique compounds such as phytol, benzoic acid, pyrocatechol, and furanones. LC–MS analysis detected 15 non-volatile secondary metabolites, predominantly flavonoids (e.g., kaempferol-3-O-β-D-glucuronide, luteolin, leucocyanidin), phenolics (sesamol, euparin), and terpenoids (brefeldin A, E-p-coumaric acid), of which nine are well-documented for their antioxidant properties. These compounds were identified with high accuracy (mass error ±4 ppm) across positive and negative ion modes. Antioxidant potential was confirmed through the DPPH radical scavenging assay, which yielded a moderate IC₅₀ value of 101.13 ppm and a strong dose-response correlation (R² = 0.9526). The favourable microclimatic conditions of Mount Gumitir likely contributed to the phytochemical richness observed. Collectively, these findings highlight D. hirsuta as a chemically diverse bryophyte with promising antioxidant constituents, supporting its potential application in pharmacological development and natural antioxidant sourcing.
Growth and physiological adaptation of Ageratum conyzoides L. under salinity stress Putri, Yusi Ananda; Dwinianti, Edia Fitri; Inayah, Ulfatul; Farhan, Abdillah Maulana
Life Science and Biotechnology Vol. 2 No. 1 (2024): May 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i1.49086

Abstract

Physiological stress affects all plants, including salinity stress, which poses significant challenges. Ageratum conyzoides L. was selected as the subject of this study due to its reputed ability to thrive under various stress conditions, owing to its excellent adaptive capacity. The study employed salt solutions at concentrations of 1000 ppm, 3000 ppm, and 5000 ppm, administered as a single treatment over four weeks. The aim was to assess the impact of salinity stress on the growth, stomatal density, and chlorophyll content of A. conyzoides. Results indicate that salt treatment adversely affected the height of A. conyzoides. Stomatal density was highest at the 5000 ppm concentration, attributed to intensified transpiration in response to stress compared to lower concentrations. Chlorophyll content also showed an reduced at higher salt concentrations. These findings highlight the physiological responses of A. conyzoides to salinity stress, providing insights into its adaptation mechanisms under adverse environmental conditions.
In Silico Study of Genus Marchantia using matK loci for DNA Barcoding Farhan, Abdillah Maulana; Ulum, Fuad Bahrul
Life Science and Biotechnology Vol. 2 No. 2 (2024): November 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i2.53527

Abstract

Marchantia is a genus of liverworts that can be found in the Asia-Europe Region. Some of the types that can be found are Marchantia polymorpha subsp. montivagans, Marchantia polymorpha subsp. ruderalis, Marchantia paleacea subsp. diptera. All of these species have different levels of kinship, this is due to differences in their nucleotide structure. The purpose of this study was to identify the intolerance between Marchantia species in genomic studies using the NCBI Database. The method used in this research is the collection of nucleotides on NCBI and then construction with Mega 11 software. The marker used in this study is Maturase K (matK), this is because the marker is very optimal in the identification of a molecular-based species. The results of this study are Marchantia paleacea subsp. diptera matK (MP 58 and MP 54) has the highest level of kinship with a score of 99 (Neighbor-Joining Tree) and 100 (Maximum Likelihood Tree) and the outgroup of this phylogenetic is Dumortiera hirsuta. Keywords: Marchantia, matK, NCBI, Phylogenetic.
In Silico Biological Activity Prediction of Bioactive Compounds from Dumortiera hirsuta (Sw.) Nees. Using Way2Drug PASS Online Farhan, Abdillah Maulana; Rosida, Waki'atil; Ulum, Fuad Bahrul
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The liverwort Dumortiera hirsuta (Sw.) Nees. is recognized as a potential source of pharmacologically active metabolites. Bioactive compounds from D. hirsuta have been previously reported through in vitro metabolomic analyses using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS). In this study, the biological activities of the GC-MS-identified metabolites were evaluated in silico using the Way2Drug PASS Online platform. The results indicated that ten metabolites from D. hirsuta exhibit medicinal potential, with Pa values greater than 0.7, suggesting a high probability of biological activity. Among these compounds, stigmasterol (Pa = 0.970) and lathosterol (Pa = 0.960) demonstrated the strongest antihypercholesterolemic potential, indicating their role as natural agents for reducing cholesterol levels. These findings highlight the pharmacological potential of D. hirsuta metabolites and warrant further validation through in vitro cholesterol-lowering assays to confirm their predicted activities.
Chemical Profiling of Locally Grown Zingiber officinale Roscoe (Ginger) Rhizomes using GC-MS and Biological Activities Farhan, Abdillah Maulana; Ilmiah , Ika iffah; Mufidi, Farah Fakhirah; Perkasa, Excel Taruna Reksa; Shodiq, Muhammad Husein; Shodiq, Abdulloh Hasan
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

Ginger (Zingiber officinale Roscoe), a widely used rhizomatous species of the family Zingiberaceae, possesses extensive medicinal value owing to its diverse phytochemical composition. This study aimed to characterize the bioactive constituents of locally grown ginger rhizomes using Gas Chromatography–Mass Spectrometry (GC–MS) to elucidate their potential pharmacological activities. GC–MS analysis enabled the detection of volatile and semi-volatile compounds based on retention time and molecular ion fragmentation patterns, providing a comprehensive chemical profile of the extract. A total of 39 compounds were identified, of which 14 exhibited relative abundances exceeding 3%. Major constituents included sesquiterpenes and phenolic derivatives known for their antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. The presence of these bioactive metabolites confirms the therapeutic potential of Z. officinale as a natural source of bioactive agents and supports its continued exploration for pharmaceutical and nutraceutical applications
Pengelolaan Herbal Bunga Mawar Sebagai UMKM Lokal di Karangpring Jember Maulana Farhan, Abdillah; Farhan, Abdillah Maulana; Febiani, Tika; Aulasya, Ulfie Sakha; Dexa Sya’ban, Sabaquna Biliman
Jurnal Pengabdian West Science Vol 3 No 07 (2024): Jurnal Pengabdian West Science
Publisher : Westscience Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/jpws.v3i07.1447

Abstract

Pemberdayaan ini dilakukan di Desa Karangpring Kecamatan Sukorambi, Kabupaten Jember. Desa Karangpring merupakan salah satu desa penghasil bunga mawar terbesar di jember, namun bunga mawar tersebut belum dikelola dengan baik, seperti menjadi produk UMKM herbal bunga mawar. Sehingga permasalahan dari desa tersebut adalah tidak adanya UMKM lokal yang berjalan. Kegiatan ini dilakukan bertujuan untuk memberikan suatu pandangan mengenai pengelolaan bunga mawar menjadi herbal yang berpotensi menjadi UMKM, selain itu kegiatan ini juga menjelaskan mengenai edukasi pemasaran secara digital. Hasil dari kegiatan ini adalah sediaan produk herbal bunga mawar dan strategi marketing secara digital, yang disampaikan di Balai desa Karangpring, dengan peserta sejumlah 40 masyarakat setempat.
Co-Authors Aulasya, Ulfie Sakha Azizah, Alya Najwa Dexa Sya’ban, Sabaquna Biliman Dwi Setyati Dwinianti, Edia Fitri Febiani, Tika Fuad Bahrul Ulum Gilani, Noor Azizah Ilmiah , Ika iffah Inayah, Ulfatul Masayu, Muhammad Zulfikar Arian Maulana Farhan, Abdillah Mufidi, Farah Fakhirah Perkasa, Excel Taruna Reksa Putri, Yusi Ananda Risqi, Alexandria Zazila Rosida, Waki'atil Shodiq, Abdulloh Hasan Shodiq, Muhammad Husein Su’udi, Mukhamad