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All Journal Indonesian Journal of Pharmaceutical Science and Technology Waluya The International Science of Health Journal
Abdurrahman, Syawal
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Computer Science & IT Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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Overview of the Standards and Objectives of Implementing the Dengue Hemorrhagic Fever (DHF) Control Policy through the One House One Mosquito Net Movement Program at the Rahandouna Village Health Center, Kendari City Muhammad Arsyi, La Ode; Azizi Jayadipraja, Erwin; Abdurrahman, Syawal
Waluya The International Science of Health Journal Vol. 4 No. 3 (2025): Waluya The International Science of Health Journal
Publisher : Magister Kesehatan Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/6w6y7n82

Abstract

Introduction:Dengue fever remains a serious health problem in Indonesia, including in Kendari City, with cases occurring annually. In 2023, Kendari City successfully reduced dengue fever morbidity through the "1 house, 1 mosquito larvae" initiative. This study aims to describe the "1 house, 1 mosquito larvae" initiative at the Poasia Community Health Center.Method:Qualitative research and case study design were conducted in 2024. The key informants in this study were the coordinators of infectious disease control at community health centers, while general informants included the heads of community health centers, movement managers, village heads, and the heads of the infectious disease prevention and control section of the Kendari City Health Office.Result:Demonstrate conformity with the policy implementation theory and guidelines of this movement which include standards and objectives, characteristics of implementing organizations, communication between implementing organizations, disposition, and environment (social, economic, and political).Conclusion:There is a need for training in the use of Android-based applications for coordinators and supervisors, forming a team with the Village Office and socializing how to become a Coordinator and Supervisor to the Community.
Antidiabetic Activity of Ethyl Acetate Compounds from Gayam (Inocarpus fagiferus): In Silico and In Vivo Studies Ifaya, Mus; Ridwan, Bai Athur; Laugi, Putri Salsabila; Utami, Apriliani Putri; Abdurrahman, Syawal
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.58070

Abstract

Diabetes mellitus is characterized by high blood sugar levels. Though many drugs are available, blood glucose control is still challenging to achieve due to decreased beta cell function and side effects of long-term use. Gayam tree bark (Inocarpus fagiferus) has the potential to inhibit digestive enzymes, although the molecular mechanism of its antidiabetic effect has not been ascertained. This study aims to determine the activity of compounds from ethyl acetate extract as antidiabetics, tested in silico and in vivo. The study used molecular docking and in vivo activity analysis. LC-MS analysis was used to determine the content of compounds in the ethyl acetate fraction of gayam bark. Through molecular interaction prediction and ADME-Toxicology, compounds in gayam bark showed antidiabetic activity. In the molecular docking interaction study, the Cochliophilin A compound had a lower binding energy than acarbose on the α-amylase receptor: -9.76 kcal/mol and -8.95 kcal/mol. The ADME-Tox model predicted good skin permeability, absorption, and distribution for Cochliophilin A. The ethyl acetate extract showed antidiabetic activity in lowering blood sugar levels in rats on day 14, respectively by 74% (IV), 72% (V), and 74% (VI). Collectively, compounds in gayam bark are useful in treating diabetes.
Co-Authors Bai Athur Ridwan Erwin Azizi Jayadipraja, Erwin Azizi Ifaya, Mus Laugi, Putri Salsabila Muhammad Arsyi, La Ode Utami, Apriliani Putri