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All Journal International Journal of Advances in Applied Sciences Jurnal Abdi Insani Journal of Agri-Food Science and Technology (JAFoST) Journal of Industrial Process and Chemical Engineering (JOICHE)
Putri, Mutiara Wilson
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics

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Therapeutic potential of alpha-linolenic acid from Sacha Inchi oil in cervical cancer: an in vitro study on HeLa cells Permadi, Adi; Putri, Mutiara Wilson; Akbar, Muhammad Ali
International Journal of Advances in Applied Sciences Vol 14, No 3: September 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i3.pp966-974

Abstract

This study investigated the potential of alpha-linolenic acid (ALA) from Sacha Inchi oil as a therapeutic agent for cervical cancer through an in vitro study on HeLa cells. Cervical cancer is one of the most common types of cancer in women, which is often caused by human papillomavirus (HPV) infection. Although chemotherapy therapy is one of the main methods in cancer treatment, this approach often causes side effects and drug resistance. ALA, which is one of the main components of Sacha Inchi oil, is known to have antioxidant and anti-cancer activities. In this study, Sacha Inchi oil was analyzed using liquid chromatography-high resolution mass spectrometry (LC-HRMS) for identification of its active components. Cytotoxic assays were performed using the MTT method on HeLa cells, which showed that ALA significantly inhibited cancer cell viability at low concentrations, with low IC50 values compared to the positive control compound cisplatin. These results suggest that ALA has potential as an effective anti-cancer agent against cervical cancer cells. This study concludes that ALA from Sacha Inchi oil can be a strong candidate in the development of safer and more effective cervical cancer therapy.
Phytochemical Test of Sacha Inchi Oil from Central Java Hadi, Mulyono; Permadi, Adi; Suharto, Totok Eka; Putri, Mutiara Wilson; Gulo, Herbert Alessandro Panias; Maema, Nadin Okta; Halimathusyakhdyah, Halimathusyakhdyah; Lupi, Ahmad
Journal of Agri-Food Science and Technology Vol. 6 No. 3 (2025): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jafost.v6i3.12885

Abstract

Sacha inchi oil is a seed-derived oil from the Amazon Rainforest, known for its high nutritional value and bioactive compounds. It contains essential fatty acids such as omega-3 and omega-6, along with tocopherols, polyphenols, carotenoids, and phytosterols, making it beneficial for health applications. Due to its nutritional and therapeutic properties, sacha inchi oil has gained significant attention in the food, cosmetic, and pharmaceutical industries. This study contributed to identify and analyze the bioactive compounds in sacha inchi oil extracted from seeds obtained in Central Java, Indonesia. The extraction process was carried out using a hot pressing method, followed by qualitative phytochemical analysis and LC-HRMS identification. The phytochemical tests confirmed the presence of flavonoids, alkaloids, tannins, phenolics, saponins, steroids, and terpenoids, all of which contribute to antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, LC-HRMS analysis did not detect flavonoids, tannins, and saponins, possibly due to their low concentration, matrix effects, or degradation during analysis. These findings highlight sacha inchi oil’s potential in nutraceutical, pharmaceutical, and cosmetic industries. Its bioactive compounds suggest its potential use in functional foods, dietary supplements, and therapeutic applications, particularly in preventing oxidative stress-related diseases. Further research is recommended to optimize extraction techniques, improve compound stability, and evaluate its bioavailability and long-term health benefits. The presence of bioactive compounds indicates that sacha inchi oil can be a valuable functional ingredient for health and medical applications, contributing to sustainable and natural health solutions.
Pengaruh Rasio Asam Sitrat dan 4-carboxy-3-chlorobenzene boronic acid terhadap Quantum Yield dari Graphene Quantum Dots Permadi, Adi; Putri, Mutiara Wilson
Journal of Industrial Process and Chemical Engineering (JOICHE) Vol 4, No 2 (2024)
Publisher : Institut Teknologi Adhi Tama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31284/j.joiche.2024.v4i2.7584

Abstract

This study investigates the effect of citric acid (CA) and 4-carboxyl-3-chlorobenzeneboronic acid (CBBA) ratio on the Quantum Yield (QY) of Graphene Quantum Dots (GQDs). The hydrothermal synthesis method was employed with various CA/CBBA molar ratios, and the optical properties were analyzed using UV-Vis and photoluminescence (PL) spectroscopy. The results show that increasing the CBBA ratio enhances fluorescence efficiency, with the highest QY of 5.075% obtained at a 1:5 ratio. The addition of CBBA improves surface passivation and reduces non-radiative recombination sites, thereby optimizing the photoluminescence properties. Furthermore, precursor ratio variation influences particle size and functional groups, affecting the solubility and stability of GQDs. These findings highlight the role of CBBA in controlling exciton recombination, making GQDs more efficient for optoelectronic, bioimaging, and biomedical applications. Further studies are needed to explore the long-term effects of CBBA doping on fluorescence stability
PENGUATAN MANAJEMEN PRODUKSI PASIR KUCING PADA BUMDes HARGOMULYO GUNUNG KIDUL Suharto, Totok Eka; Permadi, Adi; Syamsuddin, Arief; Putri, Mutiara Wilson; Lupi, Ahmad; Saputri, Rully Indah; Pariz, Ananda Rizky Al
Jurnal Abdi Insani Vol 12 No 11 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i11.3124

Abstract

BUMDes Hargomulyo Gedangsari Gunungkidul saat ini sedang merintis usaha pasir kucing dari batuan zeolit alam (bentonit) yang tersedia banyak di daerah setempat dan belum banyak dimanfaatkan. Namun, usaha pasir kucing tersebut terkendala dengan terbatasnya teknologi dan manajemen produksi. Kegiatan ini bertujuan untuk meningkatkan kapasitas produksi dan nilai tambah zeolit alam untuk menghasilkan produk pasir kucing yang berkualitas dan ramah lingkungan. Metode kegiatan yang dilaksanakan meliputi sosialisasi, workshop, dan pelatihan manajemen dan operasional produksi. Peningkatan keberdayaan mitra kegiatan diukur dengan istrumen tes tertulis dan observasi kinerja. Hasil kegiatan menunjukkan peningkatan pengetahuan dan keterampilan mitra sasaran dalam manajemen produksi pasir kucing dari zeolit alam. Peralatan produksi berupa mesin crusher dengan kapasitas lebih besar dan alat pengemasan produk telah dipasang dan dikuasai operasionalnya. Peningkatan keberdayaan BUMDes Hargomulyo dalam manajemen produksi yang dindikasikan dengan adanya dokumen SOP produksi, struktur organisasi, dan sistem pencatatan keuangan. Dengan menggunakan mesin crusher batuan yang telah dikembangkan, kapasitas produksi pasir kucing dapat ditingkatkan menjadi dua kali lipat dibandingkan sebelumnya. Produk pasir kucing dikemas dengan branding Pasir Zeolit Hargosuryo, 100% alami, multi-guna, dan ramah lingkungan. Kegiatan pengabdian kepada masyarakat yang telah dilakukan berhasil meningkatkan kapasitas produksi pasir kucing dari batuan zeolit alam sampai dengan 800 kg per hari melalui pengembangan mesin crusher dan pelatihan manajemen produksi pada BUMDes Hargomulyo Gunung Kidul. Produk pasir zeolit HARGOSURYO mempunyai kualitas yang baik, alami, tanpa bahan aditif, dan ramah lingkungan. Manajemen usaha diperkuat dengan terwujudnya dokumen SOP produksi, dokumen struktur organisasi, dan dan dokumen pencatatan keuangan usaha yang dapat diaplikasikan.
Co-Authors Adi Permadi, Adi Gulo, Herbert Alessandro Panias Hadi, Mulyono Halimathusyakhdyah, Halimathusyakhdyah Lupi, Ahmad Maema, Nadin Okta Muhammad Ali Akbar, Muhammad Ali Pariz, Ananda Rizky Al Saputri, Rully Indah Syamsuddin, Arief Totok Eka Suharto