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All Journal International Journal of Advances in Applied Sciences Journal of Agri-Food Science and Technology (JAFoST)
Putri, Mutiara Wilson
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Mathematics Physics

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Therapeutic potential of alpha-linolenic acid from Sacha Inchi oil in cervical cancer: an in vitro study on HeLa cells Permadi, Adi; Putri, Mutiara Wilson; Akbar, Muhammad Ali
International Journal of Advances in Applied Sciences Vol 14, No 3: September 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i3.pp966-974

Abstract

This study investigated the potential of alpha-linolenic acid (ALA) from Sacha Inchi oil as a therapeutic agent for cervical cancer through an in vitro study on HeLa cells. Cervical cancer is one of the most common types of cancer in women, which is often caused by human papillomavirus (HPV) infection. Although chemotherapy therapy is one of the main methods in cancer treatment, this approach often causes side effects and drug resistance. ALA, which is one of the main components of Sacha Inchi oil, is known to have antioxidant and anti-cancer activities. In this study, Sacha Inchi oil was analyzed using liquid chromatography-high resolution mass spectrometry (LC-HRMS) for identification of its active components. Cytotoxic assays were performed using the MTT method on HeLa cells, which showed that ALA significantly inhibited cancer cell viability at low concentrations, with low IC50 values compared to the positive control compound cisplatin. These results suggest that ALA has potential as an effective anti-cancer agent against cervical cancer cells. This study concludes that ALA from Sacha Inchi oil can be a strong candidate in the development of safer and more effective cervical cancer therapy.
Phytochemical Test of Sacha Inchi Oil from Central Java Hadi, Mulyono; Permadi, Adi; Suharto, Totok Eka; Putri, Mutiara Wilson; Gulo, Herbert Alessandro Panias; Maema, Nadin Okta; Halimathusyakhdyah, Halimathusyakhdyah; Lupi, Ahmad
Journal of Agri-Food Science and Technology Vol. 6 No. 3 (2025): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jafost.v6i3.12885

Abstract

Sacha inchi oil is a seed-derived oil from the Amazon Rainforest, known for its high nutritional value and bioactive compounds. It contains essential fatty acids such as omega-3 and omega-6, along with tocopherols, polyphenols, carotenoids, and phytosterols, making it beneficial for health applications. Due to its nutritional and therapeutic properties, sacha inchi oil has gained significant attention in the food, cosmetic, and pharmaceutical industries. This study contributed to identify and analyze the bioactive compounds in sacha inchi oil extracted from seeds obtained in Central Java, Indonesia. The extraction process was carried out using a hot pressing method, followed by qualitative phytochemical analysis and LC-HRMS identification. The phytochemical tests confirmed the presence of flavonoids, alkaloids, tannins, phenolics, saponins, steroids, and terpenoids, all of which contribute to antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, LC-HRMS analysis did not detect flavonoids, tannins, and saponins, possibly due to their low concentration, matrix effects, or degradation during analysis. These findings highlight sacha inchi oil’s potential in nutraceutical, pharmaceutical, and cosmetic industries. Its bioactive compounds suggest its potential use in functional foods, dietary supplements, and therapeutic applications, particularly in preventing oxidative stress-related diseases. Further research is recommended to optimize extraction techniques, improve compound stability, and evaluate its bioavailability and long-term health benefits. The presence of bioactive compounds indicates that sacha inchi oil can be a valuable functional ingredient for health and medical applications, contributing to sustainable and natural health solutions.
Co-Authors Adi Permadi, Adi Gulo, Herbert Alessandro Panias Hadi, Mulyono Halimathusyakhdyah, Halimathusyakhdyah Lupi, Ahmad Maema, Nadin Okta Muhammad Ali Akbar, Muhammad Ali Totok Eka Suharto