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Utami, Indah Woro
Program Studi Farmasi, Fakultas Humaniora Dan Kesehatan, Universitas Mulia, Balikpapan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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DAYA HAMBAT EKSTRAK DAUN SAMBILOTO (Andrograpis paniculata ) TERHADAP JAMUR Candida albicans DENGAN METODE DIFUSI DISK CAKRAM Indah Woro Utami
DINAMIS Vol 2 No 12 (2016): DINAMIS
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Sains dan Teknologi Jayapura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58839/jd.v2i12.559

Abstract

Telah dilakukan penelitian dengan judul Daya hambat ekstrak daun sambiloto(Andrographis paniculata) terhadap jamur Candida albicans dengan metode difusi diskcakram. Penelitian ini bertujuan untuk mengetahui daya hambat ekstrak daun sambiloto(Andrograpis paniculata) terhadap jamur candida albicans dengan metode difusi diskcakram. Populasi yang digunakan dalam penelitian adalah semua tanaman sambiloto(Andrograpis paniculata) yang terdapat di wilayah Koya Kabupaten Jayapura dan JamurCandida albicans (biakan murni). Sampel yang digunakan dalam penelitian ini adalah daunsambiloto dan jamur Candida albicans. Metode uji daya hambat yang digunakan padapenelitian ini adalah metode difusi disk cakram, dimana penelitian dilakukan secara triplo.Pengukuran zona hambat dilakukan setelah media diinkubasi selama ± 24 jam. Hasil reratapengukuran zona hambat pada media adalah 13,75 mm. Hal ini menunjukan bahwa daunsambiloto terbukti dapat menghambat pertumbuhan jamur Candida albicans.
Penggunaan Ganja Medis Dalam Pengobatan Rasional Dan Pengaturannya di Indonesia Nur Arfiani; Indah Woro Utami
Jurnal Hukum dan Etika Kesehatan VOLUME 2 NOMOR 1
Publisher : Magister Ilmu Hukum - Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jhek.v2i1.45

Abstract

Medical marijuana (Cannabis sativa) has been used since ancient time. Its use is written in medical books from china, india and even the Mesopotamian era. In these records, the use of marijuana (Cannabis sativa) is not only as a medicine, but also as a food ingredient and a ritual tool. A popular issue in Indonesia today is about legalization of medical marijuana. Marijuana is a class I narcotic which is written in the law. Cannabis has a very high potential to cause addicted and not used for therapy. However, several institutions have discussed that marijuana can be legalized in Indonesia. Cannabis can provide health benefits and has economic potential. Marijuana countains cannabinoids that are considered to have medical benefits. Several countries have developed marijuana into legal medicinal preparations. Economically, medical marijuana has great potential as an export commodity. The approach in this study uses a qualitative method by using data from books, regulations, expert opinions, as well as examining various scientific journal using Garuda, PubMed, Sciencedirect, and Wiley. The result of data analysis is in the form of systematic information. This article can be a reference for development and legalization of medical marijuana in Indonesia.
Aktivitas Sediaan Gel Antiseptik Tangan Berbahan Aktif Ekstrak Fraksi Etanol Daun Sungkai (Peronema canencens Jack.) terhadap Beberapa Bakteri Patogen Arsyik Ibrahim; Indah Woro Utami; Risna Agustina
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.94

Abstract

Penelitian Aktivitas Sediaan Gel Antiseptik Tangan Berbahan Aktif Ekstrak Fraksi Etanol Daun Sungkai (Peronema Canencens Jack.) telah dilakukan. Penelitian ini bertujuan mengetahui aktivitas antiseptik fraksi daun Sungkai (P. canescens. Jack) secara in vitro terhadap beberapa bakteri patogen dalam sediaan gel antiseptic tangan dan mengetahui konsentrasi terbaik fraksi etanol daun Sungkai (P. canencens Jack.) dalam sediaan gel antiseptik tangan terhadap masing-masing strain mikroba patogen. Bahan uji diperoleh dengan fraksinasi ekstrak fraksi etanol daun sungkai, selanjutnya formulasikan ke dalam basis gel antiseptic, diuji aktivitasnya terhadap beberapa bakteri pathogen dan menentukan konsentrasi terbaik fraksi etanol daun Sungkai (P. canencens Jack.) dalam sediaan gel antiseptik tangan terhadap bakteri Escherichia coli, Salmonella thyposa, Staphylococcus aureu, Bacillus subtilis. Metode pengujian antibakteri mengunakan uji difusi padat secara in vitro. Hasil penelitian menunjukan konsentrasi fraksi etanol dalam sediaan gel antiseptik aktif terhadap bakteri Escherichia coli, Salmonella thyposa, Staphylococcus aureus dan Bacillus subtillis. Konsentrasi terbaik ekstrak etanol dalam sediaan gel antiseptik adalah 4% efektif menghambat/membunuh ke tiga bakteri uji. Kata kunci : P. canencens Jack, Gel antiseptik, E. coli, S. thyposa, S. aureus, B. subtlisABSTRACTA research which antiseptic hand gel preparations containing the active leaf extract fraction ethanol Sungkai (Peronema canencens Jack.) has been done. This study aims to know is antiseptic activity Sungkai leaf fraction (P. canescens. Jack) in vitro against to several microbial pathogens in the preparation of antiseptic hand gel, and to know determine the best concentration of ethanol fraction Sungkai leaf in the preparation of antiseptic gel hands each strain of pathogenic bacteria. Test materials obtained by fractionation of the ethanol extract of the leaf fraction Sungkai, further formulated into a gel base antiseptic, tested its activity against several bacterial pathogens, and determine the best concentration of ethanol fraction Sungkai leaf in the preparation of antiseptic hand gel against Staphylococcus aureus, Salmonella thyposa, Escherichia coli and Bacillus subtilis bacteria. Antibacterial testing using method in vitro solid diffusion test. The results showed the concentration of ethanol fraction in gel dosage of active antiseptic against Staphylococcus aureus, Salmonella thyposa, Escherichia coli and Bacillus subtilis bacteria. The best concentration of ethanol extract in the preparation of antiseptic gel was 4% effective at inhibiting or kill the to three bacteria. Keywords: P. canencens Jack, antiseptic gel, E. coli, S. thyposa, dan S. aureu, B. subtllis
Pengaruh Pemberian Minyak Ikan terhadap Hasil Terapi Pasien Skizofrenia Rawat Inap Berdasarkan Skala PANSS: The Effect of Fish Oil Administration on the Therapeutic Outcome of Schizophrenic Inpatients Based on the PANSS Scale Warrantia Citta Citti Putri; Nishia Waya Meray; Indah Woro Utami
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pemberian minyak ikan sebagai terapi tambahan skizofrenia dapat menurunkan nilai Positive and Negative Syndrome Scale (PANSS) pada pasien rawat inap di Rumah Sakit Grhasia. Penelitian cross sectional dilakukan dengan pre-test and post-test with control group design, minyak ikan diberikan 2 kali sehari 1 kapsul selama 6 minggu dan skala PANSS digunakan untuk menilai efektifitas terapi. Untuk pengambilan sampel diambil menggunakan metode consecutive sampling dan data yang diperoleh akan dianalisis menggunakan uji-t berpasangan. Hasil penelitian menunjukkan rata-rata 50 poin pada 22 kelompok perlakuan dan rata-rata penurunan sebesar 39,4 poin pada 22 kelompok kontrol. Dapat disimpulkan pemberian minyak ikan sebagai terapi tambahan dalam pengobatan pasien skizofrenia akan memberikan hasil terapi yang lebih baik daripada tidak diberikan tambahan minyak ikan.
Aktivitas Antibakteri Air Perasan Jeruk Purut (Citrus hystrix DC.) terhadap Bakteri Salmonella thypi secara In Vitro: Antibacterial Activity of Kaffir lime juice (Citrus hystrix DC.) Against Salmonella thypi In Vitro Indah Woro Utami; Eka Kumala Retno; Warrantia Citta Citti Putri
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1738

Abstract

Kaffir lime (Citrus hystrix DC.) is a plant that is widely used to treat influenza, scaly and peeling skin, hair care, and so on. Kaffir lime contains various beneficial chemical compounds, such as citric acid, amino acids and essential oil. The flavonoid content in kaffir lime essential oil is one of the compounds that is strongly suspected of acting as a good antibacterial compound. Salmonella thypi is a gram-negative bacterium that is the causative agent of diarrhea and typhoid fever. This bacterium has the most serious form of infection compared to other genus because it can cause complications of intestinal perforation and bleeding. The purpose of this study was to test the antibacterial activity of kaffir lime juice on Salmonella thypi bacteria. This study was conducted with Kirby-Bauer diffusion method. Antibacterial activity is seen from the clear zone that inhibits the growth of Salmonella thypi bacteria in Petri dishes. There were 4 concentrations of kaffir lime juice tested, namely 25%, 50%, 75%, and 100% as well as amoxicillin antibiotic as positive control and sterile distilled water as negative control. The test was conducted with three repetitions. The results showed that the higher the concentration of kaffir lime juice, the greater the inhibition zone formed. Kaffir lime juice already has inhibition against Salmonella typhi growth in the first 5 minutes. Keywords: Kaffir lime (Citrus hystrix DC.), Salmonella thypi, Antibacterial Abstrak Jeruk purut (Citrus hystrix DC.) merupakan tanaman yang banyak digunakan untuk mengobati influenza, kulit yang bersisik dan mengelupas, perawatan rambut, dan sebagainya. Jeruk purut mengandung berbagai senyawa kimia yang bemanfaat, seperti asam sitrat, asam amino dan minyak atsiri. Kandungan flavonoid dalam minyak atsiri jeruk purut menjadi salah satu senyawa yang diduga kuat berperan sebagai senyawa antibakteri yang baik. Salmonella thypi adalah bakteri gram negatif yang merupakan agen penyebab diare dan demam tifoid. Bakteri ini memiliki bentuk infeksi yang paling serius dibandingkan genus lainnya karena dapat menyebabkan komplikasi perforasi usus dan pendarahan. Tujuan dari penelitian ini untuk menguji aktivitas antibakteri air perasan jeruk purut pada bakteri Salmonella thypi. Penelitian ini dilakukan dengan metode difusi Kirby-Bauer. Aktifitas antibakteri terlihat dari adanya zona bening yang menghambat pertumbuhan bakteri Salmonella thypi di cawan petri. Terdapat 4 konsentrasi air perasan jeruk purut yang diuji, yaitu 25%, 50%, 75%, dan 100% serta antibiotik amoxicillin sebagai kontrol positif dan aquadest steril sebagai kontrol negatif. Pengujian dilakukan dengan tiga kali pengulangan. Hasilnya didapatkan bahwa semakin tinggi konsentrasi perasan air jeruk purut maka semakin besar zona hambat yang terbentuk. Air perasan buah jeruk purut sudah memiliki daya hambat terhadap pertumbuhan Salmonella typhi pada lama waktu 5 menit pertama. Kata Kunci: Jeruk purut (Citrus hystrix DC.), Salmonella thypi, Antibakteri
EXPLORATION OF BIOACTIVE COMPOUNDS OF RAMBUSA (Passiflora foetida L.) ROOT EXTRACT FROM EAST KALIMANTAN COAL RECLAMATION LAND AS ANTIOXIDANT Meray, Nishia Waya; Utami, Indah Woro; Nurazizah
Jurnal Kimia Riset Vol. 9 No. 2 (2024): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i2.63620

Abstract

The rambusa plant (Passiflora foetida L.) is a species utilized as a cover crop due to its capacity to undergo a natural regeneration process in the context of former coal mining operations in East Kalimantan. Rambusa plants have many phytochemical properties, one of which is as an antioxidant. Nevertheless, there is currently a paucity of scientific data regarding the potential antioxidant properties of bioactive compounds in Rambusa roots utilized as cover crop plants. The objective of this study is to investigate the composition of bioactive compounds in the root extract of Rambusa plants that are cultivated on land previously utilized for coal mining in East Kalimantan, with a particular focus on their antioxidant properties. In this study, the exploration was carried out by conducting phytochemical tests using three types of solvents, namely ethanol, ethyl acetate and n-hexane and antioxidant activity tests using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method on the extracted samples. Phytochemical screening results showed the presence of alkaloid, phenolic, flavonoid, terpenoid and saponin bioactive compounds in ethanol extract; alkaloid, phenolic and steroid bioactive compounds in ethyl acetate extract. At the same time, alkaloids and steroids are contained in the n-hexane extract. The DPPH test carried out on the three extracts showed very strong antioxidant activity with IC50 values respectively for ethanol, ethyl acetate and n-hexane extracts are 6.55 ppm, 3.51 ppm and 28.71 ppm. Based on previously reported antioxidant activity data, the antioxidant activity of Rambusa (Passiflora foetida L.) roots growing on coal reclamation land is proven to have much higher activity compared to Rambusa plants growing on fertile land. Thus, the root of the Rambusa plant (Passiflora foetida L.) has enormous potential as an antioxidant and natural medicinal raw material.
Uji Aktivitas Antijamur Ekstrak Propolis dari Lebah Trigona Sp Asal Balikpapan terhadap Candida Tropicalis Muthia Adlina; Indah Woro Utami; Nishia Waya Meray
Jurnal Rumpun Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v5i3.5522

Abstract

Fungal infections are a common health problem in tropical regions, including Indonesia, since humid conditions support microbial growth. Candida tropicalis is a pathogenic species frequently identified as the cause of both superficial and systemic candidiasis. The rising resistance to synthetic antifungal agents such as fluconazole and ketoconazole highlights the need for safer and more effective alternative therapies. Propolis, a resinous substance produced by Trigona sp. bees from various plant sources, contains flavonoids, phenolics, and terpenoids with important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening revealed the presence of alkaloids, flavonoids, phenolics, tannins, and terpenoids in the extract. Antifungal activity testing showed that concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone of 27.93 mm observed at 100% concentration. Statistical analysis using ANOVA confirmed significant differences among treatments. Thus, ethanol extract of Trigona sp. propolis from Balikpapan demonstrates strong potential as a natural antifungal agent. These findings support the use of propolis as a natural-based therapeutic alternative for fungal infections and contribute to the development of herbal pharmaceutical products.
Analisis Aktivitas Antibakteri Ekstrak Etil Asetat Tanaman Sirih Cina (Peperomia pellucida L.) pada Bakteri Shigella Dysenterie A. Nurul Fitriandini Ekaputri; Indah Woro Utami; Eka Kumala Retno
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i4.3356

Abstract

Dysentery is a gastrointestinal infection characterized by bloody or mucoid diarrhea, abdominal pain, and tenesmus. One of its main causative agents is Shigella dysenteriae , a Gram-negative bacterium capable of causing epidemics and showing resistance to various antibiotics. Therefore, alternative treatments are needed, one of which is the use of traditional medicinal plants such as Peperomia pellucida L. (“sirih cina”). This study aimed to determine the ability of the ethyl acetate extract of Peperomia pellucida L to inhibit the growth of Shigella dysenteriae , and to identify the most effective concentration in exhibiting antibacterial activity. The research was conducted experimentally in the laboratory, involving simplisia preparation, maceration extraction with ethyl acetate, phytochemical screening, and antibacterial testing using the agar well diffusion method. Three extract concentrations were tested (20%, 25%, and 30%), with ciprofloxacin (5 µg) as the positive control and 5% DMSO as the negative control. Phytochemical screening revealed the presence of flavonoids, tannins, and terpenoids, while alkaloids, steroids, and saponins were not detected. Antibacterial assays showed that all extract concentrations inhibited the growth of S. dysenteriae with inhibition zones >20 mm (classified as very strong). The highest activity was observed at 30% concentration with an average inhibition zone of ±22.6 mm, approaching the effectiveness of ciprofloxacin. This study demonstrates that the ethyl acetate extract of P. pellucida possesses strong antibacterial activity and has potential as an alternative or combination therapy to reduce antibiotic resistance.
Uji Aktivitas Antijamur Ekstrak Propolis dari Lebah Trigona Sp asal Balikpapan terhadap Candida Tropicalis Muthia Adlina; Indah Woro Utami; Nishia Waya Meray
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i4.3377

Abstract

Fungal infections are common health problems in tropical regions, including Indonesia, because humid environmental conditions support the growth of these microorganisms. Candida tropicalis is the pathogenic fungal species most frequently found, both as the cause of superficial and systemic candidiasis. The increasing resistance to synthetic antifungal drugs, such as fluconazole and ketoconazole, creates the need for alternative therapies that are safer and more effective. Propolis, a resinous substance produced by Trigona bees from various plant sources, is known to contain flavonoids, phenolics, and terpenoids that have important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening showed that the propolis extract contained alkaloids, flavonoids, phenolics, tannins, and terpenoids. The antifungal activity test demonstrated that extract concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone observed at 100% concentration (27.93 mm). Statistical analysis using ANOVA confirmed significant differences among treatments. Therefore, it can be concluded that propolis extract from Trigona bees in Balikpapan has strong potential as a natural antifungal agent. These findings support the utilization of propolis as an alternative natural-based therapy for fungal infections and as a contribution to the development of natural pharmaceutical products.
Comparison of Characteristics and Antibacterial Activity of Mandai Cempedak Vinegar with Variations in Fermentation Methods Utami, Indah Woro; Sapri, Sapri; Meray, Nishia Waya; Canrika, Rezia Elok
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.9140

Abstract

Mandai, a traditional fermented food product from East Kalimantan, is derived from the edible mesocarp of the cempedak (Artocarpus champeden) fruit. This ancestral fermentation technique, passed down through generations, is known to produce lactic acid bacteria (LAB) with potential probiotic properties. This study aimed to characterize LAB isolated from mandai vinegar and evaluate their antibacterial activity under two distinct fermentation conditions: a defined starter culture of Lactobacillus casei strain Shirota and spontaneous fermentation in a 10% NaCl solution. The latter, referred to as salt fermentation, yielded three bacterial colonies, while the starter culture method produced four. All isolates from both methods shared similar morphological characteristics, including a rod shape, white coloration, entire margins, and convex surfaces. Further analysis confirmed they were Gram-positive, catalase-negative, and indole-negative, with the ability to ferment various carbohydrates. While all LAB isolates demonstrated generally low antibacterial activity against Escherichia coli ATCC 25922, isolate CML 1 exhibited the highest antibacterial potential. These findings highlight the potential of mandai vinegar as a source of functional LAB, warranting further investigation into its applications as a functional food ingredient.
Co-Authors A. Nurul Fitriandini Ekaputri Arif, Ratna Arsyik Ibrahim As'ari, As'ari Canrika, Rezia Elok Eka Kumala Retno Eka Kumala Retno Meray, Nishia Waya Muthia Adlina Nur Arfiani Nurazizah Retno, Eka Kumala Rezia Elok Canrika Risna Agustina sapri sapri Warrantia Citta Citti Putri