Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Jurnal Riset Kimia JURNAL PHOTON
Zulmy, Winda Permata
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Chemistry Nursing Physics

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Synthesis of Pyridazinone Derivatives Substituted with Methoxy with Phenyl Hydrazine and In Silico Test of Anticancer Activity Zulmy, Winda Permata; Sholihah, Putri Mar Atus; Yuda Teruna, Hilwan; Jasril
Jurnal Riset Kimia Vol. 16 No. 2 (2025): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v16i2.809

Abstract

The synthesis of pyridazinone derivatives has gained increasing attention due to their diverse biological activities, particularly as anticancer agents. In this study, novel pyridazinone derivatives substituted with methoxy groups and phenyl hydrazine were synthesized through a multi-step reaction pathway, starting from methoxyacetophenone and glyoxylic acid, followed by cyclization and substitution reactions to yield the target compound 7-(2-methoxyphenyl)-2H-pyridazino[6,1-c][1,2,4]triazine-3(4H)-one. The synthesized compounds were characterized by melting point, TLC, HPLC, UV-Vis, FTIR, NMR, and MS analyses, confirming the expected structures. In silico evaluation was performed using molecular docking against estrogen receptor α (ERα) kinase domain (PDB ID: 1T46), a key protein in breast cancer progression. The docking results showed that the synthesized compounds exhibited strong binding affinities, with compound 8 displaying a binding free energy of –9.1971 kcal/mol and stable interactions with residues Cys673, Leu799, and Phe811. These values were superior compared to the natural ligand and comparable to the reference drug doxorubicin, indicating significant anticancer potential. The results suggest that structural modification of pyridazinone with methoxy and phenyl hydrazine substituents enhances its cytotoxic activity, making it a promising candidate for further development as an anticancer agent.
The Synthesis and Molecular Docking Assay of 2-(3-3,4-dimethoxyphenyl)-6-oxopyridazin-1(6H)-yl)acetohydrazide as a candidate for breast anticancer shalihah, putri; zulmy, winda permata; hendra, rudi; jasril
Photon: Jurnal Sain dan Kesehatan Vol. 16 No. 1 (2025): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v16i1.9167

Abstract

Piridazinon merupakan golongan senyawa heterosiklik dengan aktivitas biologis yang luas, salah satunya sebagai antikanker. Penelitian ini mensintesis turunan piridazinon yang disubstitusi N-asetohidrazida dan mengevaluasi potensinya sebagai terapi kanker payudara melalui studi docking molekuler. Senyawa target, 2-(3-(3-metoksifenil)-6-oksopiridazina-1(6H)-il)asetohidrazida (3) , disintesis melalui tiga langkah reaksi: kondensasi untuk membentuk inti piridzinon, fungsionalisasi etil kloroasetat pada posisi nitrogen, dan substitusi gugus etoksi dengan hidrazin hidrat. Rendemen yang diperoleh adalah 48,14%. Kemurnian senyawa yang disintesis dikonfirmasi melalui penentuan titik leleh dan analisis kromatografi cair kinerja tinggi (HPLC), yang menunjukkan satu puncak dominan. Elucidasi struktur menggunakan Fourier-transform infrared (FTIR), spektrometri massa (MS), resonansi magnetik nuklir proton ( 1H -NMR), dan resonansi magnetik nuklir karbon-13 ( 13C -NMR) memverifikasi struktur yang diharapkan. Studi penambatan molekuler terhadap tirosin kinase (PDB ID: 3ERT) menunjukkan bahwa senyawa (3) memiliki energi bebas pengikatan sebesar -7,93 kkal/mol, dengan dua ikatan hidrogen yang terbentuk dengan residu Glu353 dan Leu387. Hasil ini menunjukkan bahwa senyawa (3) belum menunjukkan aktivitas penghambatan yang lebih baik daripada tamoxifen. Meskipun demikian, senyawa ini memenuhi karakteristik fisikokimia yang baik berdasarkan aturan Lipinski, sehingga tetap menjanjikan untuk pengembangan lebih lanjut.
Co-Authors Hendra, Rudi Jasril Jasril shalihah, putri Sholihah, Putri Mar Atus Yuda Teruna, Hilwan