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All Journal Hydrogen: Jurnal Kependidikan Kimia
Miranda, Esti
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Chemistry Education

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Literature Review: Bioactivity of Alkaloids from Various Plants that Have Potential as Antibacterials Usman; Hutauruk, Kevin Jeremia; Rabiah, Nasya Hikmatul; Rahmadani, Intan Aulia; Miranda, Esti
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 4 (2025): August 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i4.16734

Abstract

Alkaloid compounds are active secondary metabolite compounds produced by plants. These alkaloid compounds provide extraordinary health benefits for humans because alkaloid compounds are efficacious as antidiarrheal, anti-microbial, anti-diabetic, anti-microbial, and anti-malarial. The purpose of this literature review is to describe plants that produce alkaloid compounds as secondary metabolites and their bioactivity as antimicrobials. This literature-based study was systematically carried out to gather, evaluate, and synthesize research results concerning the antibacterial properties of alkaloids and other natural secondary metabolites from plants. The analysis focused on publications from 2015 to 2025, sourced through a structured search in the Medline database using PubMed and Google Scholar. The results of this literature review explain that there are many plants that produce alkaloid compounds as their secondary metabolites. Alkaloid compounds in each plant have the same bioactivity both as anti-fungal and anti-fungal. Alkaloids in their bioactivity will interfere with and damage cell formation in microbes so that microbial growth will be inhibited.
Phytochemical Profile and Antioxidant Activity of Bandotan (Ageratum conyzoides L.) Leaves from East Kalimantan Hajar, Ayu Iradha Umi; Indah, Marwa; Miranda, Esti; Nuraini, Indah; Kusuma, Aldi; Erika, Farah
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.16179

Abstract

Ageratum conyzoides L. is a wild plant known to contain secondary metabolites with potential antioxidant activity, such as flavonoids and phenolics. However, the content and activity of active compounds in the leaves of A. conyzoides growing in the Berau region, East Kalimantan, have not been extensively studied. This study aims to evaluate the phytochemical content and antioxidant activity of ethanol extracts from A. conyzoides leaves collected from the Batu Putih area, Berau. The samples, in the form of fresh leaves, were dried and ground before being extracted using the maceration method with 96% ethanol as the solvent. The resulting extract was then subjected to phytochemical screening to identify groups of active compounds and tested for antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, with absorbance measured at a wavelength of 420 nm. Phytochemical screening results indicated the presence of alkaloids, phenolics, and tannins, while flavonoids, terpenoids, and triterpenoids were not detected. The antioxidant assay showed that the extract exhibited strong activity, with an IC50 value of 61.89 ppm, although it was still higher than that of vitamin C, which had an IC50 value of 26.77 ppm. In conclusion, the ethanol extract of A. conyzoides leaves from Batu Putih has potential as a natural antioxidant source and is worthy of further development in the pharmaceutical field.
Co-Authors Farah Erika Hajar, Ayu Iradha Umi Hutauruk, Kevin Jeremia Indah Nuraini, Indah Indah, Marwa Kusuma, Aldi Rabiah, Nasya Hikmatul Rahmadani, Intan Aulia Usman