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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Pijar MIPA Borneo Journal of Pharmacy
Aly, M. Ainun Najib
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Mathematics Medicine & Pharmacology Physics Other

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Physicochemical Profile and Stability of Red Ginger (Zingiber officinale var. rubrum) SNEDDS as Potential Aphrodisiac Pratama, Edo; Aly, M. Ainun Najib; Istiqamah, Farida; Widyowati, Retno; Sukardiman, Sukardiman
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.9691

Abstract

This study investigated the stability of a Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulated with Zingiber officinale var. rubrum (red ginger) extract. SNEDDS formulations, composed of an oil phase, co-surfactant, and surfactant, are designed to create stable isotropic mixtures, critical for drug delivery systems. Prior to assessing long-term physical stability, the optimal Z. officinale var. rubrum SNEDDS preparation underwent comprehensive characterization, including evaluation of emulsification time, pH, particle size, polydispersity index (PDI), and zeta potential. Subsequent physical stability assessments involved rigorous centrifugation, hot-cold, and freeze-thaw cycles. The results demonstrated an emulsification time of ≤1 minute, a pH value of 5.04±0.05, and a particle size of 14.92±0.7 nm, indicative of a nanoscale dispersion. The PDI was 0.282, and the zeta potential was −18.57±1.30 mV, suggesting good colloidal stability. Crucially, throughout six cycles of centrifugation, hot-cold, and freeze-thaw stress tests, the Z. officinale var. rubrum extract SNEDDS exhibited no signs of phase separation, sedimentation, cracking, or creaming. These findings collectively confirm that the prepared Z. officinale var. rubrum extract SNEDDS meets critical physicochemical characteristics and demonstrates excellent physical stability, positioning it as a promising candidate for further development as a natural extract delivery system.
Formulation, Physical Characterization, and Stability Study of Nanoemulgel Containing Jatropha curcas Leaves Extract Aly, M. Ainun Najib; Pratama, Edo; Shobahah, Jauharotus; Munandar, Tristiana Erawati; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.407-413

Abstract

Background: Jatropha curcas extract has been identified as a promising herbal remedy for various skin disorders. However, its application is limited by its low water solubility and poor skin permeability. Nanotechnology-based strategies provide a way to overcome these limitations. Objective: This study aimed to develop a new drug delivery system for J. curcas extract as a topical treatment for skin conditions. Methods: J. curcas extract was obtained through maceration. The system included a Carbopol 940-based gel and a J. curcas extract (JCE 10% w/w) nanoemulsion (NE) created using a high-energy method with an ultrasonic homogenizer. The appearance, pH, viscosity, spreadability, particle size, polydispersity index, and zeta potential of the nanoemulgel were assessed to verify its physical properties. Results: The optimal formulation produced a dark green nanoemulgel with a distinctive leafy smell and a semi-solid texture. Physical characterization of the JCE-NE-gel included a pH of 6.3, particle size of 142.67 nm, polydispersity index of 0.248, zeta potential of -23.23 mV, viscosity of 87.881 cP, and spreadability of 6.13 cm. Stability testing showed no significant differences after accelerated stability testing and thermal cycling. Conclusion: The study demonstrated that J. curcas extract (JCE-NE-gel) was successfully incorporated into a nanoemulgel formulation (F4), showing excellent physical properties and stability.
Computational Evaluation of Vitamin D3 Binding to KRAS and TGF-β1 in Colorectal Cancer–Associated Signalling Pathways Shobahah, Jauharotus; Astuti , Wahyuningsih Sri Puji; Herdiansyah, Mochammad Aqilah; Aly, M. Ainun Najib
Jurnal Pijar MIPA Vol. 21 No. 2 (2026)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11643

Abstract

Vitamin D3 has been widely investigated for its anticancer properties, yet the structural basis of its interaction with key oncogenic signaling proteins remains incompletely understood. This study aimed to evaluate the molecular interactions between vitamin D3 and KRAS and TGF-β1 using molecular docking and molecular dynamics simulations. Molecular docking analysis was performed using AutoDock Vina, followed by molecular dynamics simulation using CABS-flex to evaluate structural stability using root mean square deviation (RMSD), root mean square fluctuation (RMSF), and radius of gyration (Rg). Comparative benchmarking was performed against the reference inhibitors Sotorasib (KRAS) and Galunisertib (TGF-β pathway). Docking analysis revealed that vitamin D3 binds to KRAS (PDB ID: 4OBE) with a binding affinity of –7.8 kcal/mol, compared to –8.6 kcal/mol for Sotorasib. The interaction was localized within the nucleotide-binding pocket adjacent to the Switch I and Switch II regions, which are critical for conformational regulation. For TGF-β1 (PDB ID: 3KFD), vitamin D3 demonstrated a binding affinity of –8.2 kcal/mol, slightly exceeding that of Galunisertib (–8.1 kcal/mol), with interaction occurring at the receptor-binding interface. Molecular dynamics simulation showed stable complex formation, with RMSD values of 2.79 Å for the KRAS complex and 1.535 Å for the TGF-β1 complex, indicating acceptable structural stability. Residue fluctuation analysis further supported moderate flexibility without global destabilization. These findings suggest that vitamin D3 may function as a multi-target signaling modulator interacting with both intracellular and extracellular regulators of colorectal cancer pathways, providing a structural basis for further experimental investigation.
Co-Authors Astuti , Wahyuningsih Sri Puji Herdiansyah, Mochammad Aqilah Istiqamah, Farida Munandar, Tristiana Erawati Pratama, Edo Retno Widyowati Shobahah, Jauharotus Sukardiman