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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Insan Farmasi Indonesia Borneo Journal of Pharmacy
Istiqamah, Farida
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Social Sciences Other

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IDENTIFIKASI SENYAWA FITOKIMIA EKSTRAK ETANOL 70% AKAR GINSENG KUNING (RENNELLIA ELLIPTICA KORTH.) MENGGUNAKAN LC-MS/MS DAN AKTIVITAS AFRODISIAKA SECARA IN SILICO Istiqamah, Farida; Sukardiman, Sukardiman; Widyowati, Retno
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 11, No 2 (2024)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v11i2.870

Abstract

Abstrak Latar belakang: Rennellia elliptica Korth. secara tradisional digunakan sebagai zat afrodisiak. Dilihat dari potensinya, bukti ilmiah ekstrak tumbuhan ini sebagai penghambat phosphodiesterase-5 masih belum dilakukan Tujuan: Penelitian ini bertujuan untuk mengetahui senyawa fitokimia yang terdapat pada ekstrak etanol 70% tanaman rennellia elliptica Korth. menggunakan LC-MS/MS dan aktivitas afrodisiakan secara in silico. Metode: Ekstrak etanol rennellia elliptica Korth. dianalisis menggunakan LC-MS/MS selanjutnya senyawa tersebut digunakan sebagai senyawa ligan dalam penambatan molekuler untuk mengetahui afinitas pengikatan konstituen fitokimia tersebut terhadap protein target phosphodiesterase 5 (PDB ID: 2H42). Hasil: Ditemukan 17 komponen senyawa antara lain golongan terpenoid, fenilpropanoid, antrakuinon dan flavonoid. Berdasarkan studi in silico dari 17 senyawa yang dianalisis dengan LC-MS/MS, Dulxanthone B (∆G=-9,52 kkal/mol) menunjukkan afinitas tertinggi untuk berikatan dengan target protein. Simpulan: Senyawa fitokimia dari rennellia elliptica Korth. dapat berfungsi sebagai terapi tambahan dalam penemuan obat untuk pengobatan yang menghambat phosphodiesterase 5. Abstract Background: Rennellia elliptica Korth. is traditionally used as an aphrodisiac substance. Judging from its potential, scientific evidence of this plant extract as a phosphodiesterase-5 inhibitor has yet to be conducted. Objective: . This research aims to determine the phytochemical compounds contained in the 70% ethanol extract of the Rennellia elliptica Korth plant. using LC-MS/MS. Method: The ethanol extract of rennellia elliptica Korth. was analyzed using LC-MS/MS and then the compounds were used as ligand compounds in molecular docking to determine the binding affinity of the phytochemical constituents to the target protein phosphodiesterase 5 (PDB ID: 2H42). Results: 17 compound components were found, including terpenoids, phenylpropanoids, anthraquinones and flavonoids. Based on in silico studies of 17 compounds analyzed by LC-MS/MS, Dulxanthone B (∆G=-9.52 kcal/mol) showed the highest affinity for binding to protein targets.. Conclusions: Phytochemical compounds from Rennellia elliptica Korth. may serve as an adjunct therapy in drug discovery for treatment that inhibits phosphodiesterase 5.
KESESUAIAN PENYIMPANAN OBAT HIGH ALERT DI INSTALASI FARMASI RUMAH SAKIT X BANJARMASIN Ilahi, Fitrah Shafran; Rahmah; Yumassik, Abdul Mahmud; Nordin; Ainah, Nur; Istiqamah, Farida; Faqih, Muhammad
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2521

Abstract

High Alert is a type of drug that needs to be taken seriously as it can often lead to fatal errors and also has a high potential to trigger Adverse Drug Reactions. These drugs are divided into three categories, namely High Risk drugs, High Concentrate Electrolytes, and Look Alike Sound Alike/ Drug Name Look and Sound Similar. The purpose of this study was to assess the suitability of High Alert drug storage at the Banjarmasin X Hospital Pharmacy Installation based on the standard operating procedure for High Alert drug storage. The research method used qualitative observational with a cross-sectional approach. The study sample included 158 items of High Alert drugs in the Pharmacy Warehouse, Outpatient Pharmacy Depot, and Inpatient Pharmacy Depot, taken using the Total Sampling technique and data collected prospectively using a checklist sheet. Then processed with Microsoft Excel based on standard operating procedures. The results showed that the suitability of High Alert drug storage in the Pharmacy Warehouse was 99% (61 items), Outpatient Pharmacy Depot was 100% (41 items), and Inpatient Pharmacy Depot was 98% (51 items). Overall, the average suitability of High Alert drug storage in the three depots is 99% suitable in drug storage.
Physicochemical Profile and Stability of Red Ginger (Zingiber officinale var. rubrum) SNEDDS as Potential Aphrodisiac Pratama, Edo; Aly, M. Ainun Najib; Istiqamah, Farida; Widyowati, Retno; Sukardiman, Sukardiman
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.9691

Abstract

This study investigated the stability of a Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulated with Zingiber officinale var. rubrum (red ginger) extract. SNEDDS formulations, composed of an oil phase, co-surfactant, and surfactant, are designed to create stable isotropic mixtures, critical for drug delivery systems. Prior to assessing long-term physical stability, the optimal Z. officinale var. rubrum SNEDDS preparation underwent comprehensive characterization, including evaluation of emulsification time, pH, particle size, polydispersity index (PDI), and zeta potential. Subsequent physical stability assessments involved rigorous centrifugation, hot-cold, and freeze-thaw cycles. The results demonstrated an emulsification time of ≤1 minute, a pH value of 5.04±0.05, and a particle size of 14.92±0.7 nm, indicative of a nanoscale dispersion. The PDI was 0.282, and the zeta potential was −18.57±1.30 mV, suggesting good colloidal stability. Crucially, throughout six cycles of centrifugation, hot-cold, and freeze-thaw stress tests, the Z. officinale var. rubrum extract SNEDDS exhibited no signs of phase separation, sedimentation, cracking, or creaming. These findings collectively confirm that the prepared Z. officinale var. rubrum extract SNEDDS meets critical physicochemical characteristics and demonstrates excellent physical stability, positioning it as a promising candidate for further development as a natural extract delivery system.
IDENTIFIKASI SENYAWA FITOKIMIA EKSTRAK ETANOL 70% AKAR GINSENG KUNING (RENNELLIA ELLIPTICA KORTH.) MENGGUNAKAN LC-MS/MS DAN AKTIVITAS AFRODISIAKA SECARA IN SILICO Istiqamah, Farida; Sukardiman, Sukardiman; Widyowati, Retno
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 11 No 2 (2024)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v11i2.870

Abstract

Abstrak Latar belakang: Rennellia elliptica Korth. secara tradisional digunakan sebagai zat afrodisiak. Dilihat dari potensinya, bukti ilmiah ekstrak tumbuhan ini sebagai penghambat phosphodiesterase-5 masih belum dilakukan Tujuan: Penelitian ini bertujuan untuk mengetahui senyawa fitokimia yang terdapat pada ekstrak etanol 70% tanaman rennellia elliptica Korth. menggunakan LC-MS/MS dan aktivitas afrodisiakan secara in silico. Metode: Ekstrak etanol rennellia elliptica Korth. dianalisis menggunakan LC-MS/MS selanjutnya senyawa tersebut digunakan sebagai senyawa ligan dalam penambatan molekuler untuk mengetahui afinitas pengikatan konstituen fitokimia tersebut terhadap protein target phosphodiesterase 5 (PDB ID: 2H42). Hasil: Ditemukan 17 komponen senyawa antara lain golongan terpenoid, fenilpropanoid, antrakuinon dan flavonoid. Berdasarkan studi in silico dari 17 senyawa yang dianalisis dengan LC-MS/MS, Dulxanthone B (∆G=-9,52 kkal/mol) menunjukkan afinitas tertinggi untuk berikatan dengan target protein. Simpulan: Senyawa fitokimia dari rennellia elliptica Korth. dapat berfungsi sebagai terapi tambahan dalam penemuan obat untuk pengobatan yang menghambat phosphodiesterase 5. Abstract Background: Rennellia elliptica Korth. is traditionally used as an aphrodisiac substance. Judging from its potential, scientific evidence of this plant extract as a phosphodiesterase-5 inhibitor has yet to be conducted. Objective: . This research aims to determine the phytochemical compounds contained in the 70% ethanol extract of the Rennellia elliptica Korth plant. using LC-MS/MS. Method: The ethanol extract of rennellia elliptica Korth. was analyzed using LC-MS/MS and then the compounds were used as ligand compounds in molecular docking to determine the binding affinity of the phytochemical constituents to the target protein phosphodiesterase 5 (PDB ID: 2H42). Results: 17 compound components were found, including terpenoids, phenylpropanoids, anthraquinones and flavonoids. Based on in silico studies of 17 compounds analyzed by LC-MS/MS, Dulxanthone B (∆G=-9.52 kcal/mol) showed the highest affinity for binding to protein targets.. Conclusions: Phytochemical compounds from Rennellia elliptica Korth. may serve as an adjunct therapy in drug discovery for treatment that inhibits phosphodiesterase 5.
Co-Authors Ainah, Nur Aly, M. Ainun Najib Ilahi, fitrah shafran Muhammad Faqih Nordin Pratama, Edo Rahmah Retno Widyowati Sukardiman Yumassik, Abdul Mahmud