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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) IJCER (International Journal of Chemistry Education Research) FORTE JOURNAL
Pramundita Ramadani, Arba
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Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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NON-CODING RNA (ncRNA) IN DIABETIC NEPHROPATHY: A REVIEW Fitriani, Hannie; Hikmah, Uzulul; Ferneda, Larysa; Pramundita Ramadani, Arba
FORTE JOURNAL Vol 5 No 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i2.1446

Abstract

Diabetes Nefropati (DN) merupakan penyebab utama terjadinya end‐stage kidney disease. Studi molekuler menunjukkan ncRNA berperan penting dalam mengatur peradangan ginjal, apoptosis, autofagi, proliferasi sel, dan fibrosis ginjal di DN. Pada penelitian ini dilakukan tinjauan artikel mengenai ncRNA sebagai prospek baru dalam pengembangan diagnosis, prognosis, dan pengobatan untuk DN. Metode penelitian dilaksanakan dengan pendekatan studi literatur yang diperoleh dari penelusuran pada database elektronik pubmed dan google scholar dengan kata kunci “ncRNA and diabetes nephropathy” yang mencakup terkait etiologi, patofisiologi, biomarker. ncRNA yang meliputi miRNA, lncRNA, circRNA berperan dalam progresifitas penyakit DN. Studi mengenai ncRNA sebagai terapi masih dalam tahap pengembangan. Miravirsen dan RG-101 adalah beberapa obat miRNA yang telah diuji klinis, tetapi belum ditemukan obat miRNA yang spesifik untuk DN. Salah satu inovasi terapi yang dikembangkan adalah nanopartikel-miRNA-146a-5p (nano-miR-146a-5p) yang menunjukkan aktivitas penekanan ekspresi inflamasi sitokin yang memiliki efek perlindungan yang terjadi melalui regulasi respon inflamasi dan apoptosis. Pengembangan terapi ncRNA pada DN membutuhkan penelitian dan kajian lebih lanjut, sehingga mampu menjadi pilihan pengobatan DN di masa medatang.
Improving Students’ Knowledge and Engagement in Immunology Course Using Video-Based Learning and Concept Mapping in Modified E-tivities Triastuti, Asih; Pramundita Ramadani, Arba
IJCER (International Journal of Chemistry Education Research) VOLUME 8, ISSUE 1, APRIL 2024
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijcer.vol8.iss1.art3

Abstract

E-tivities were implemented in the online class of Immunology at the Department of Pharmacy UII using video-based learning (VBL) and concept mapping exercises to enhance student motivation and knowledge. The class measurement method was used by comparing the previous academic year's lecture evaluation and outcomes (the 2021 semester without video and concept mapping) and the 2022 semester (with E-tivities using VBL and concept mapping). According to the evaluation results, the combination of learning methods with learning video and concept mapping increased the student's interest and enthusiasm for learning. Furthermore, the student's mastery of the material increased from 8% to 41%, resulting in an increase in the student's final grade. The combination of video-based learning and concept mapping increased student motivation and knowledge
Nanotechnology-Based Formulations of Curcuma xanthorrhiza for Modern Herbal Therapy: A Narrative Literature Review: Formulasi Berbasis Nanoteknologi Curcuma xanthorrhiza Roxb. sebagai Terapi Herbal Modern: Tinjauan Literatur Naratif Fitriani, Hannie; Luthfiansyah Azhar, Hanif; Syukri, Yandi; Pramundita Ramadani, Arba
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17972

Abstract

Background: Curcuma xanthorrhiza Roxb. (temulawak) is an Indonesian medicinal plant with documented antibacterial, anti-inflammatory, antioxidant, hepatoprotective, and anticancer activities, yet its major active compounds, curcuminoids and xanthorrhizol, suffer from poor aqueous solubility, low stability, and very limited oral bioavailability. Objectives: This study aims to review nanotechnology-based formulation strategies developed to overcome the biopharmaceutical limitations of C. xanthorrhiza and to optimise its potential as a modern herbal therapy. Methods: A narrative literature review was conducted using national and international articles published mainly between 2015 and 2025 that were retrieved from PubMed, ScienceDirect, and Google Scholar with keywords related to Curcuma xanthorrhiza, nanoformulation, and drug delivery systems; data were qualitatively summarised according to type of nanoformulation, physicochemical characteristics, and in vitro or in vivo biological activities. Results: Various nanotechnology-based delivery systems were identified, including nanosuspensions, nanoemulsions, Solid Lipid Nanoparticles (SLN), Self-Nanoemulsifying Drug Delivery Systems (SNEDDS), Solid-SNEDDS, nanogels, polymeric nanoparticles, and green-synthesised metallic nanoparticles; these formulations consistently reduced particle size to the nanometre range, improved solubility and chemical stability, increased entrapment efficiency, and enhanced pharmacological effects such as anti-inflammatory, antioxidant, antimicrobial, and anticancer activities compared with conventional extracts. Conclusions: Nanotechnology-based formulations of Curcuma xanthorrhiza represent a promising strategy to improve the efficacy, safety, and practicality of temulawak as a modern herbal medicine, and further well-designed preclinical and clinical studies are required to confirm their therapeutic advantages.
Co-Authors Asih Triastuti Ferneda, Larysa Fitriani, Hannie Hikmah, Uzulul Luthfiansyah Azhar, Hanif Yandi Syukri