Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan
Chozin, Iin
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Rare Case : Lymphangioleiomyomatosis in a 28 year-old woman with spontaneous bilateral pneumothorax Matabei, Shannon Conversia Pdabo; Djajalaksana, Susanthy; Chozin, Iin; Erawati, Dini; Wardhana, Koernia; Yudhanto, Hendy; Rahman, Perdana; Chen, Chung-Yu
Malang Respiratory Journal Vol. 7 No. 2 (2025): Volume 7 No 2, September 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.02.04

Abstract

Introduction: Lymphangioleiomyomatosis (LAM) is an extremely rare disease with no known exact cause, in which there are abnormalities in the development of smooth muscle cells. This condition manifests in multiple organs, one of which is the lungs. Prevalence of LAM is 1 in 1,000,000, most commonly found in women of reproductive age. Pneumothorax occurs in two-thirds of LAM patients. It is possibly underdiagnosed in Indonesia. Case report: A 28-year-old woman came to the Emergency Department with sudden severe shortness of breath. Chest X-ray shows bilateral pneumothorax predominantly on the left side, and a chest tube was installed. Thorax MSCT revealed multiple cysts in all areas of lungs, while abdominal USG and MRI discovered masses in uterus and right adrenal. Left bullectomy-thoracotomy and lung biopsy were performed, with histopathology result supporting LAM. The patient was stable post surgery. LAM is associated with mutations in TSC1 or TSC2 genes, resulting in cystic changes caused by LAM cells proliferation in the lungs. In this patient, bilateral pneumothorax resulted from multiple subpleural cysts which eventually ruptured. Diagnosis of LAM was established by radiological imaging and lung biopsy. Surgical and non-surgical interventions were performed to address the acute manifestations of LAM. Unfortunately, Sirolimus which is the recommended long-term medication for LAM is not yet available in Indonesia. Conclusion: LAM is a rare disease. It’s important for clinicians to be familiar with this condition, aware of its progression and possible recurrence of pneumothorax, in order to provide appropriate interventions.
Pengaruh Jintan Hitam (Nigella sativa) terhadap Kadar Hypoxia-Inducible Factor (HIF-1), Vascular Endothelial Growth Factor (VEGF), Haemoglobin (Hb), dan Neutrophil-Lymphocyte Ratio (NLR) pada Pasien Kanker Paru Asyari, Claudia Herda; Pratiwi, Suryanti; Chozin, Iin; Izzati, Arina
Jurnal Klinik dan Riset Kesehatan Vol 4 No 3 (2025): Volume 4 No 3, Juni 2025
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.3.4

Abstract

Pendahuluan: Insidensi dan angka kematian akibat kanker paru terus meningkat, sebagian besar disebabkan oleh keterlambatan dalam proses diagnosis. Beberapa penanda yang berhubungan dengan perkembangan kanker paru meliputi faktor hypoxia-inducible factor (HIF-1), vascular endothelial growth factor (VEGF), haemoglobin (HB) dan neutrophil-lymphocyte ratio (NLR). Tujuan: Tujuan studi ini untuk menganalisis perbedaan kadar HIF-1, VEGF, HB dan NLR terhadap pemberian jintan hitam (Nigella sativa). Metode: Penelitian kuantitatif dengan metode pre and post test control group dengan melibatkan 21 sampel yang terbagi menjadi kelompok perlakuan dan kontrol. Kriteria inklusi subjek berupa berusia >18 tahun, terdiagnosis kanker paru primer stadium IIB, IIIA, IIIB, IVA, dan IVB, serta bersedia mengikuti penelitian dan menandatangani informed consent. Kriteria eksklusi subjek adalah pasien kanker primer di luar organ paru dan terdapat kendala di dalam pengambilan data, yang menimbulkan data tidak lengkap. Semua subjek penelitian diberikan kemoterapi dan pada kelompok perlakuan ditambahkan kapsul jintan hitam 500 mg diberikan secara oral dua kali sehari selama sembilan minggu. HIF-1, VEGF, Hb dan NLR diukur sebelum dan setelah sembilan minngu pemberian kemoterapi. Dilakukan analisis uji-t berpasangan untuk menilai perbedaan HIF-1, VEGF, HB dan NLR antara sebelum dan setelah sembilan minggu pemberian kemoterapi. Hasil: Terdapat perbedaan signifikan pada kadar HIF-1, VEGF, Hb dan NLR diantara kelompok kontrol dan perlakuan setelah 9 minggu dengan berturut-turut nilai p= 0,009; p=0,007; p=0,021 dan nilai p= 0,009. Kesimpulan: Pemberian jintan hitam (Nigella sativa) bermanfaat dalam menurunkan kadar HIF-1, VEGF dan NLR dan meningkatkan kadar Hb pada pasien kanker paru
Co-Authors Asyari, Claudia Herda Chen, Chung-Yu Djajalaksana, Susanthy Erawati, Dini Izzati, Arina Matabei, Shannon Conversia Pdabo Pratiwi, Suryanti Rahman, Perdana Wardhana, Koernia Yudhanto, Hendy