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Pratiwi, Suryanti
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Karakteristik Faal Paru Berdasarkan Pemeriksaan Spirometri pada Pasien Suspek Tumor Paru dan Mediastinum Pratiwi, Suryanti; Agus Setyawan, Ungky; Listyoko, Aditya; Kirana, Intan
Jurnal Klinik dan Riset Kesehatan Vol 1 No 3 (2022): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.3.3

Abstract

Pendahuluan: Keganasan paru merupakan penyakit paru yang memiliki tingkat kematian tertinggi di dunia. Pemeriksaan untuk mengetahui fungsi paru dengan menggunakan spirometri. Tujuan: Penelitian ini bertujuan untuk mengetahui distribusi faal paru pasien dengan diagnosis suspek tumor paru dan mediastinum di Rumah Sakit Saiful Anwar (RSSA) Malang berdasarkan usia, jenis kelamin, indeks massa tubuh (IMT), dan diagnosis. Metode: Penelitian deskriptif analitik, pendekatan cross-sectional dengan menggunakan data rekam medis Januari 2018 – Desember 2019 kemudian dilakukan uji spearman. Hasil: Hasil penelitian menunjukkan diagnosis suspek tumor paru dan mediastinum paling banyak pada rentang usia 51-60 tahun, jenis kelamin terbanyak laki-laki, diagnosis terbanyak tumor paru. Hasil interpretasi pemeriksaan spirometri terbanyak menunjukkan restriksi, dan IMT normal. Hasil analisis hubungan gambaran faal paru memiliki p-value pada suspek tumor paru dan mediastinum (0,814), jenis kelamin (0,003), dan IMT (0,360). Kesimpulan: Terdapat hubungan yang signifikan antara gambaran faal paru dengan jenis kelamin dan tidak didapatkan hubungan yang signifikan antara gambaran faal paru dengan diagnosis dan IMT.
Progression Free Survival pada Pasien Kanker Paru Adenokarsinoma Wild Type dengan Kombinasi Regimen Pemetrexed dengan Cisplatin dibandingkan dengan Karboplatin Agus Setyawan, Ungky; Purnamawati, Catur; Pratiwi, Suryanti
Jurnal Klinik dan Riset Kesehatan Vol 4 No 2 (2025): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.2.2

Abstract

Pendahuluan: Progression-free survival (PFS) adalah parameter untuk mengukur perkembangan kanker paru adenokarsinoma wild type. Berbagai studi literatur telah menunjukkan bahwa kombinasi kemoterapi berbasis platinum-pemetreksed lebih efektif untuk progresivitas adenokarsinoma wild type yang berkepanjangan. Tujuan: Tujuan penelitian ini membandingkan PSF pasien adenokarsinoma wild type yang mendapat rejimen sisplatin-pemetreksed dan karboplatin-pemetreksed di Rumah Sakit Dr. Saiful Anwar tahun 2018-2021. Metode: Penelitian kohort retrospektif berdasarkan medical record pasien adenokarsinoma wild type. Hasil: Hasil penelitian menunjukkan bahwa pemberian rejimen karboplatin-pemetreksed memiliki PFS yang lebih panjang (median 4 bulan, 95% CI 2.657-5.343) dibandingkan dengan sisplatin-pemetreksed (median 2 bulan, 95% CI 0.988-3.012). Selain itu risiko progresivitas kanker paru berdasarkan PFS tidak dipengaruhi secara signifikan oleh nilai skala Karnofsky 70-80 (72,2%, HR 0,278). Sebaliknya, riwayat merokok meningkatkan risiko progresivitas kanker paru, walaupun tidak berpengaruh secara signifikan (HR 1.538). Kesimpulan: Pemberian rejimen karboplatin-pemetreksed memperpanjang PFS hingga 10-16 bulan, meskipun tidak ada perbedaan yang signifikan secara statistik bila dibandingkan dengan sisplatin-pemetreksed.
The Chemical Pneumonitis due to Hydrochloric Acid in Suicide Attempts: Chemical Pneumonitis due to Hydrochloric Acid in Suicide Attempts Rahadiyanti, Harini; Pratiwi, Suryanti; Astuti, Tri
Malang Respiratory Journal Vol. 7 No. 2 (2025): Volume 7 No 2, September 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.02.03

Abstract

Introduction: Pneumonia cases globally infected 450 million people in 2022, with 25.3% being pneumonitis cases. Chemical pneumonia is inflammation of the lungs caused by chemicals that are acidic or basic. Chemical pneumonia has a mortality of up to 70%. Case report: A 21-year-old female college student came to the emergency room with the chief complaint of shortness of breath and vomiting. The patient has an introvert. From the anamnesis, there was a history of drinking 100 cc of floor cleaning liquid (hydrochloric acid). After 15 minutes she felt nauseous and vomited, accompanied by coughing and shortness of breath due to aspiration. In the CXR, bilateral infiltrates were dominant on the right, and on the CT scan, there was Ground Glass Opacity and fibrosis; the patient was diagnosed with pneumonitis. Clinical improvement was obtained after administering antibiotics and steroids as the main therapy. Patients with a history of drinking chemicals have a risk of aspiration, which can cause complications in the lungs, especially because the material is corrosive. The presence of a gagging reflex causes the liquid to enter the airways. Precise diagnosis can be made with appropriate investigations to minimize the risk of more severe respiratory complications. Conclusion: Chemical pneumonitis can occur in cases of suicide attempts, with fast and appropriate management of anti-inflammatory agents for 7-14 days, which can minimize the risk of respiratory defects and mortality.
Karakteristik Faal Paru Berdasarkan Pemeriksaan Spirometri pada Pasien Suspek Tumor Paru dan Mediastinum Pratiwi, Suryanti; Agus Setyawan, Ungky; Listyoko, Aditya; Kirana, Intan
Jurnal Klinik dan Riset Kesehatan Vol 1 No 3 (2022): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.3.3

Abstract

Background: Lung malignancy is a lung disease that has the highest mortality rate in the world. An examination to determine the state of lung function is spirometry. Aim: This study aims to determine the distribution of lung function in patients with suspect of lung and mediastinal tumor at Saiful Anwar Hospital Malang based on age, sex, body mass index (BMI), and diagnosis. Methods: This research is a descriptive analytic, cross-sectional approach using medical record data from January 2018 to December 2019 and then the data would be processed by spearman test. Results: The results showed that patients with suspect lung and mediastinal tumors suffered the most in the age range of 51-60 years, the sexes were mostly male, the most diagnoses were lung tumors. Most of the interpretation results of the spirometry examination showed restriction, and normal body mass index. The results of the analysis of the relationship between pulmonary function descriptions had a p-value of 0.814 for diagnosis of suspected lung and mediastinal tumor, 0.003 for gender, and 0.360 for BMI. Conclusion: It can be concluded that there is a significant relationship between pulmonary function and gender and there is no significant relationship between pulmonary function with the diagnosis and BMI.
Progression Free Survival pada Pasien Kanker Paru Adenokarsinoma Wild Type dengan Kombinasi Regimen Pemetrexed dengan Cisplatin dibandingkan dengan Karboplatin Agus Setyawan, Ungky; Purnamawati, Catur; Pratiwi, Suryanti
Jurnal Klinik dan Riset Kesehatan Vol 4 No 2 (2025): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.2.2

Abstract

Background: Progression-free survival (PFS) is a parameter to measures the progression of wild type adenocarcinoma lung cancer. Literature studies have shown that the combination platinum based-pemetrexed chemotherapy is more effective to prolonged progressivity of wild type adenocarcinoma. Aim: The aim of study to compared the PSF of wild type adenocarcinoma patients receiving cisplatin-pemetrexed and pemetrexed-carboplatin regimens at Dr. Saiful Anwar Hospital in 2018-2021. Methods: A retrospective cohort study based on medical record of wild type adenocarcinoma patients. Results: The results showed that the administration of a carboplatin-pemetrexed regimen has prolonged PFS (median 4 months, 95% CI 2.657-5.343) compared to the cisplatin-pemetrexed regimen (median 2 months, 95% CI 0.988-3.012). In addition, the risk of lung cancer progression based on PFS is not significantly influenced by the Karnofsky scale value of 70-80 (72.2%, HR 0.278). On the other hand, a history of smoking increases the risk of lung cancer progression, although it does not have a significant effect (HR 1,538). Conclusion: Administration of the carboplatin-pemetrexed regimen prolongs PFS up to a range of 10-16 months, although there is no statistically significant difference compared to the cisplatin-pemetrexed.
Pengaruh Jintan Hitam (Nigella sativa) terhadap Kadar Hypoxia-Inducible Factor (HIF-1), Vascular Endothelial Growth Factor (VEGF), Haemoglobin (Hb), dan Neutrophil-Lymphocyte Ratio (NLR) pada Pasien Kanker Paru Asyari, Claudia Herda; Pratiwi, Suryanti; Chozin, Iin; Izzati, Arina
Jurnal Klinik dan Riset Kesehatan Vol 4 No 3 (2025): Volume 4 No 3, Juni 2025
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.3.4

Abstract

Pendahuluan: Insidensi dan angka kematian akibat kanker paru terus meningkat, sebagian besar disebabkan oleh keterlambatan dalam proses diagnosis. Beberapa penanda yang berhubungan dengan perkembangan kanker paru meliputi faktor hypoxia-inducible factor (HIF-1), vascular endothelial growth factor (VEGF), haemoglobin (HB) dan neutrophil-lymphocyte ratio (NLR). Tujuan: Tujuan studi ini untuk menganalisis perbedaan kadar HIF-1, VEGF, HB dan NLR terhadap pemberian jintan hitam (Nigella sativa). Metode: Penelitian kuantitatif dengan metode pre and post test control group dengan melibatkan 21 sampel yang terbagi menjadi kelompok perlakuan dan kontrol. Kriteria inklusi subjek berupa berusia >18 tahun, terdiagnosis kanker paru primer stadium IIB, IIIA, IIIB, IVA, dan IVB, serta bersedia mengikuti penelitian dan menandatangani informed consent. Kriteria eksklusi subjek adalah pasien kanker primer di luar organ paru dan terdapat kendala di dalam pengambilan data, yang menimbulkan data tidak lengkap. Semua subjek penelitian diberikan kemoterapi dan pada kelompok perlakuan ditambahkan kapsul jintan hitam 500 mg diberikan secara oral dua kali sehari selama sembilan minggu. HIF-1, VEGF, Hb dan NLR diukur sebelum dan setelah sembilan minngu pemberian kemoterapi. Dilakukan analisis uji-t berpasangan untuk menilai perbedaan HIF-1, VEGF, HB dan NLR antara sebelum dan setelah sembilan minggu pemberian kemoterapi. Hasil: Terdapat perbedaan signifikan pada kadar HIF-1, VEGF, Hb dan NLR diantara kelompok kontrol dan perlakuan setelah 9 minggu dengan berturut-turut nilai p= 0,009; p=0,007; p=0,021 dan nilai p= 0,009. Kesimpulan: Pemberian jintan hitam (Nigella sativa) bermanfaat dalam menurunkan kadar HIF-1, VEGF dan NLR dan meningkatkan kadar Hb pada pasien kanker paru
Severe Abdominal Pain Due To Gastrointestinal Obstruction in Patient With Lung Adenosquamous Metastases in Colon Zata Dini; Pratiwi, Suryanti; Setyawan, Ungky; Budianto, Aries; Yudhanto, Hendy; Erawati, Dini
Malang Respiratory Journal Vol. 5 No. 1 (2023): Volume 5 No 1, March 2023
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2023.005.01.5

Abstract

Background: Lung cancer is the most common cause of cancer-related death globally. Moreover, metastatic cancer from the lungs frequently occurs and is commonly identified at the first diagnosis. The primary cancer must be identified in order to establish the most effective treatment. However, colonic metastases are rare with incidence of 0,1%. Aim: This report describes an unusual case of colonic metastases from lung adenocarcinoma. Methods: Patient (58-year-old male) was examined with Fiber Optic Bronchoscopy and core biopsy in the lungs, and the results were suspicious for squamous cells. The patient had severe abdominal pain and bloating for 1 week and had signs of gastrointestinal obstruction in his second visit. The result of urgent laparotomy was adenosquamous and the result of immunohistochemical examination was negative P40 and positive Napsin A in both lungs and colon. Results: The lung biopsy result indicated squamous cell and the ceccum showed adenosquamous. The immunohistochemical examination using P40 and Napsin A of both lung and ceccum specimens indicated that the lung was the primary source of metastases to the colon. Conclusion: The patient suffered from a squamous cell lung tumor and reported severe abdominal pain due to metastases to the colon with adenosquamous results.
A Case Report : Thymoma Mimicking Teratoma Clinically and Radiographic Appearance Eka Pratiwi; Djajalaksana, Susanthy; Pratiwi, Suryanti; Isharanto, Artono; Erawati, Dini; Yudhanto, Hendy
Malang Respiratory Journal Vol. 6 No. 1 (2024): March 2024 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.01.03

Abstract

Background: Thymoma is a rare tumor of thymic epithelial cells in anterior mediastinum. The etiology of thymoma is not known with certainty. Thymomas are difficult to distinguish from teratomas or other mediastinal tumors. Diagnosis of thymoma or teratoma is based on clinical symptoms, CXR, Thorax CT Scan, biopsy for definite diagnosis, and requires IHC examinations to be able to differentiate it from other mediastinal tumors. Case Presentation: A 62-year-old female, came with complaints of shortness of breath since 5 months when walking long distances accompanied by a dry cough for 1 week, and weight loss of 4 kgs in 10 months. Patient came from Lawang Hospital with results of AFP 1.59, B-HCG 3.8, CXR showed mediastinal mass, CT Scan Thorax showed solid mass with fat component and calcification in the right side of anterior mediastinum, suspected of a mature teratoma. Patient then underwent Tumor Excision Per Median Sternotomy by Cardiothoracic Surgeon on October 19, 2022, sampled a round tissue sized 7.5x7x6 cm with smooth surface, intact capsule likes teratoma. Discussion: PA examination was performed, with result of Germ Cell Tumor, we continued with Calretinin, CD99, SMA, S100, and Melan A IHC examinations. The results of the last IHC examination found, Type A Thymoma Cells. Patient is currently stable and recommended for radiotherapy. Conclusion: A patient with a thymoma mimicking a mature teratoma macroscopically and radiographically is an interesting case based on the results of thymoma type A from Immunohistochemistry examination but perform macroscopic likes teratoma. Keywords: Thymoma, Teratoma, Clinically, Radiographic
Co-Authors Agus Setyawan, Ungky Aries Budianto Asyari, Claudia Herda Chozin, Iin Djajalaksana, Susanthy Eka Pratiwi Erawati, Dini Intan Kirana Isharanto, Artono Izzati, Arina Listyoko, Aditya Purnamawati, Catur Rahadiyanti, Harini Setyawan, Ungky Tri Astuti Yudhanto, Hendy Zata Dini