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All Journal Jambura Journal of Chemistry Genbinesia Journal of Biology
Suduri, Adam
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology

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Analisis Kemiripan Obat, Prediksi Toksisitas dan Studi Molecular Docking Metabolit Sekunder Dari Streptomyces carpaticus Terhadap Protein Caspase-3 Sebagai Antikanker Leukemia Suduri, Adam; Darusman, Huda Shalahudin; Mariya, Silmi
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.26802

Abstract

Caspase-3 merupakan enzim protease yang berperan dalam proses apoptosis, dan menjadi target senyawa metabolit dalam menghambat pertumbuhan sel kanker. Tujuan penelitian adalah untuk mengetahui sifat kemiripan obat metabolit sekunder hasil produksi Streptomyces carpaticus yang diperoleh berdasarkan analisis klaster gen biosintesis pada program antiSMASH version 7.1.0, mengetahui hasil prediksi mutagenicity dan toxicity serta mengetahui hasil interaksi metabolit sekunder dengan protein Caspase-3 yang merupakan reseptor terkait sel kanker leukemia menggunakan molecular docking. Hasil analisis kemiripan obat dan prediksi ADME menunjukkan bahwa ketiga metabolit memenuhi aturan Lipinski Rule of Five dan memiliki kemiripan dengan obat. Ketiga metabolit tergolong pada Toxicity Class 5, dan memiliki sifat mutagenic inactive dengan probability Pristinol: 0.93, Raimonol: 0.91 dan Cyslabdan: 0.80 dan toxicity inactive dengan probability Pristinol: 0.75, Raimonol: 0.94 dan Cyslabdan: 0.76. Hasil studi molecular docking, analisis dan validasi situs ikatan dengan protokol penambatan ulang (redocking) ligan standar 5-[4-(1-carboxymethyl-2-OXO-propylcarbamoyl)-benzylsulfamoyl]-2-Hydroxy-Benzoic Acid memiliki nilai RMSD yaitu 0.000. Energi ikatan bebas masing-masing ligan yaitu sebesar -8,9 kkal/mol -9.2 kkal/mol, -7.0 kkal/mol, -7.1 kkal/mol, dan -7.0 kkal/mol. Hasil ini menunjukan bahwa energi ikatan hasil penambatan metabolit sekunder dengan protein Caspase-3 yang paling baik adalah metabolit cyslabdan dengan nilai ikatan bebas -7.4 kkal/mol dan jumlah interaksi 12.
Utilization sugarcane waste (Saccarhum officinarum L.) as a bioetanol basic material through a bioprocess engineering approach based microbes Mohamad, Danial; Lanti, Syahrul; Dwiyani, Annisa; Matalauni, Citra Leonita; Suduri, Adam
Genbinesia Journal of Biology Vol. 4 No. 1 (2024): November 2024
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v4i1.70

Abstract

Sugarcane (Saccharum officinarum L.) is a plant that is able to produce a lot of sugar content in its stem organs. The amount of sugar production from sugar cane, of course, produces and leaves bagasse waste. A number of studies have shown that bagasse waste still contains a lot of important materials, one of which contains lignocellulose substrates that have the potential to be converted into bioethanol raw materials. The purpose of this study is to determine, see and assess the production of bioethanol produced by utilizing sugarcane waste as raw material through a microbial-based bioprocess engineering approach. This research is an experimental type with the treatment of free cells and immobilized cells in bioethanol production by utilizing sugarcane waste as raw material with the stages of processing waste into flour, dried, hydrolyzed, and analyzed sugar content before ethanol production test. Based on the results of research on ethanol testing using free cells, the highest alcohol content was obtained at a concentration of 3% and 4%. For the test of ethanol content using immobilized cells, the highest ethanol content was obtained at a concentration of 4%.
Co-Authors Dwiyani, Annisa Huda Shalahudin Darusman Lanti, Syahrul Matalauni, Citra Leonita Mohamad, Danial SILMI MARIYA