<![CDATA[Ibuprofen is a part of the Non Steroid Anti-Inflamatory Drug (NSAID) that serves as the treatment of pain or inflammation. Ibuprofen is a part of biopharmaceutical classification system (BCS) class II drug with the characteristics of low solubility and high permeability. Solid dispersion may increase solubility. Ibuprofen has a variety of side effects so it need to be made into other routes of administration such as topical. This study was conducted to understand the effect of combinations of carbopol as the gelling agent and glycerin as a penetration enhancer compound to the physical quality and the release of active substances also to determine the optimum formula. This study used simplex lattice design method with two factors which is carbopol and glycerin in formula 1 ; formula 2 ; formula 3 in sequence 100%:0% ; 50%:50% ; 0%:100%. The solid dispersion was made by the melting method, then was tested with FTIR and then was made into a solid dispersion gel of ibuprofen-PEG 6000. The release of substance was tested using franz diffusion cell through a cellophane membrane, then the optimum formula was determined based on the counterplot from Design Expert 10.0.1 trial version with critical parameters of adhesion, viscosity, and penetration of substance. The result of the study showed that carbopol and glycerin affecting the physical quality and the release of a drug in a gel. Glycerin has more impact to the release of the drug. The proportion of carbopol 1,011% and glycerin 7,389% produce the optimum formula with the most excellent physical quality and the release of the drug.]]>
