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All Journal Pharmacoscript Journal of Natural Product for Degenerative Diseases
Andam Dewi, Mira
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health

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Enhanced Efficacy of Kaffir Lime (Citrus hystrix) Essential Oil Spray Gel Against Aedes aegypti Mosquitoes Nugroho, Gumilar Adhi; Desmiaty, Yesi; Fahleni, Fahleni; Lhu Muslimah, Lhu; Andam Dewi, Mira
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5469

Abstract

The primary mode of dengue disease transmission is by the Aedes aegypti mosquito. The essential oil derived from Kaffir lime (Citrus hystrix) leaves comprises 66.85% beta-citronellal, 6.59% beta-citronellol, 3.90% linalol, and 1.76% citronellol. These constituents exhibit repelling properties. The objective of this study was to develop a spray gel formulation using kaffir lime leaf essential oil to create an efficient repellent. The process involves tearing fresh kaffir lime leaves and subsequently distilling them with distilled water. The distillation procedure yields an essential oil that is subsequently incorporated into a spray gel formulation, with varying concentrations of 1%, 5%, and 10%. Based on the findings of the efficacy test from 3 spray gel formulas through mosquito repelling activity conducted over 6 hours, it can be concluded that all tested formulas exhibited variation in effectiveness in repelling mosquito bites. The efficacy of the protection index against Aedes aegypti mosquito bites is contingent upon the concentration of kaffir lime essential oil in the formulation. There is a positive correlation between concentration and the duration of protection.
AKTIVITAS ANTIBIOFILM EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP Staphylococcus aureus Andam Dewi, Mira; Gumilar, Anggi; Sari Indah, Wisma
Pharmacoscript Vol. 7 No. 1 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i1.1552

Abstract

Daun pepaya (Carica papaya L.) mengandung alkaloid, tanin, steroid, flavonoid dan papain yang dapat menghambat perlekatan sel dan pertumbuhan Actinomyces. Tujuan penelitian ini untuk melihat aktivitas antibiofilm ekstrak daun pepaya terhadap Staphylococcus aureus, bakteri penyebab infeksi dan resisten terhadap beberapa antibiotik. Staphylococcus aureus memiliki resistensi antibiotik yang lebih tinggi dalam bentuk biofilm dibandingkan dalam bentuk plankton. Uji turbidimetri dilakukan pada 96 well plate dengan penambahan kristal violet. Metode maserasi  dilakukan dengan pelarut air steril digunakan untuk mengekstraksi pada simplisia daun pepaya. Selanjutnya dibuat ekstrak kental daun pepaya diencerkan sehingga diperoleh dengan sepuluh konsentrasi berbeda dengan interval konsentrasi 9,76 – 5000 μg/mL.Tetrasiklin HCl dengan konsentrasi yang sama dengan ekstrak uji digunakan sebagai antibiotik pembanding. Uji aktivitas antibiofilm pada Staphylococcus aureus menunjukkan bahwa ekstrak daun pepaya memiliki aktivitas antibiofilm pada konsentrasi 625, 1250, 2500, dan 5000 μg/mL serta dapat menghambat pembentukan biofilm dengan nilai MBIC dari 625 g/mL.
Co-Authors Fahleni Fahleni Gumilar Adhi Nugroho Gumilar, Anggi Lhu Muslimah, Lhu Sari Indah, Wisma Yesi Desmiaty, Yesi