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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Kedokteran Universitas Palangka Raya Barigas: Jurnal Riset Mahasiswa
Anugerahny, Margaretha Yayu Indah
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Level of Knowledge of Using Cotton Bud with The Accident of Cerumen Impaction in Students of Faculty of Medicine, Palangka Raya University Anggraini, Dwi Ria; Anugerahny, Margaretha Yayu Indah; Augustina, Indria; Surbakti, Ranintha Br; Jabal, Arif Rahman
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 2 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i2.18606

Abstract

The ear requires proper care to function as part of the auditory system. However, many people are unaware of maintaining ear health. A contributing factor is a lack of knowledge. Cotton buds disrupt the ear's natural cleaning mechanism by pushing earwax deeper, causing cerumen impaction. This study examined the relationship between knowledge levels and cerumen impaction using a cross-sectional approach with proportionate stratified random sampling. A total of 162 respondents were involved, including 76 students from the 2021 intake and 86 from the 2022 intake. The results showed 80 respondents (49.4%) had good knowledge, 62 (38.3%) sufficient knowledge, and 20 (12.3%) insufficient knowledge. A total of 53 respondents experienced cerumen impaction. Bivariate analysis indicated a significant relationship between knowledge level and cerumen impaction. There is a relationship between the level of knowledge and the incidence of cerumen impaction in students of the Faculty of Medicine, Palangka Raya University
siRNAs targeting icaD Gene of Staphylococcus aureus to Inhibit Biofilm Formation: Structural Analysis and Efficacy Sulistina, Dinda Ananda; Praja, Rian Ka; Anugerahny, Margaretha Yayu Indah; Hanasia, Hanasia; Ysrafil, Ysrafil
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.921-926

Abstract

Antibiotic resistance in Staphylococcus aureus infections, especially those involving biofilm formation, is a global health issue. Biofilm protects bacteria from the immune system and antibiotic treatment, making them 10 to 1000 times more resistant. The icaD gene, part of the ica operon, is crucial for biofilm synthesis by enhancing the enzymes responsible for forming the biofilm matrix. The icaD gene sequence of Staphylococcus aureus was obtained from the GenBank NCBI database with the accession code CP140612.1, with a gene sequence length of 306 bp and employed several bioinformatics methods, including siDirect for designing and evaluating effective siRNA sequences to select the most promising candidates. Additionally, siRNA Scales, MaxExpect, Duplex Fold, and siPred were employed to analyze the siRNA sequence length, secondary structure, binding energy, and efficacy predictions of siRNAs targeting the icaD gene. The study found that out of 54 siRNA candidates, siRNA22, siRNA50, and siRNA25 achieved inhibition rates of 93.69%, 92.82%, and 92.52%, respectively. These results bioinformatically demonstrated their potential to suppress the expression of the icaD gene and highlight their promise as siRNA-based antibacterial therapies to combat biofilm-related infections. The designed siRNA computationally shows potential as an innovative therapy to combat biofilm infections caused by Staphylococcus aureus.
Macroscopic Features of The External Auditory Canal in Patients with Otitis Externa With Otoscopic Examination at The Ent Polyclinic of Tamiang Layang Hospital Anugerahny, Margaretha Yayu Indah; Mutiasari, Dian
Jurnal Kedokteran Universitas Palangka Raya Vol 13 No 2 (2025): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v13i2.21517

Abstract

Otitis externa is one of the most painful types of inflammation is one of the common external auditory canal diseases in clinical practice. Otitis externa is an inflammation of the external auditory canal caused by bacteria, fungi. The aim of this study was to determine the characteristics of otitis externa treated at the ENT polyclinic of Tamiang Layang Hospital in 2022-2023. This study is a descriptive study using a retrospective approach using secondary data, namely medical records of patients diagnosed with otitis externa at the ENT-KL Polyclinic of Tamiang Layang Hospital in 2022-2023. This study had a sample of 335 otitis externa patients. Otitis externa occurs more in women, namely 196 patients (58.5%). The largest age group was 26-45 years, 132 patients (39.4%). The most common diagnosis was diffuse otitis externa, 291 patients (86.9%). Most macroscopic features were hyperemic
Co-Authors Anggraini, Dwi Ria Arif Rahman Jabal Augustina, Indria Dian Mutiasari, Dian Hanasia, Hanasia Ranintha br Surbakti Rian Ka Praja Sulistina, Dinda Ananda Ysrafil, Ysrafil