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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) SCRIPTA SCORE Scientific Medical Journal
Putri, Safa Nabila
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Medicine & Pharmacology

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Analisis Pengelolaan Linen Terhadap Pencegahan Dan Pengendalian Infeksi Di Rumah Sakit Islam Al Muchtar Karawang Putri, Safa Nabila; Nuraini, Ani; Aminingsih, Purwanti
Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) Vol 9, No 4 (2025): Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI)
Publisher : LPPM Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/marsi.v9i4.7143

Abstract

ABSTRAK Pengelolaan linen yang efektif merupakan elemen krusial dalam mencegah infeksi nosokomial dan meningkatkan mutu pelayanan kesehatan di rumah sakit. Penelitian ini bertujuan menganalisis pengelolaan linen di Rumah Sakit Islam Al-Muchtar Karawang dalam mendukung upaya pencegahan dan pengendalian infeksi. Pendekatan deskriptif dengan metode kualitatif eksploratif digunakan untuk mendalami praktik pengelolaan linen melalui wawancara mendalam, observasi non-partisipan, dan analisis dokumentasi. Hasil Penelitian menunjukkan bahwa Pengelolaan linen melibatkan berbagai pihak seperti Direktur, Komite PPI, dan Kepala Instalasi Laundry, namun evaluasi kebijakan yang insidental serta sosialisasi dan pelatihan yang tidak rutin menyebabkan penerapan standar operasional belum optimal. Keterbatasan fasilitas, pengawasan yang tidak konsisten, dan akses APD yang terbatas meningkatkan risiko kontaminasi dan potensi penyebaran infeksi. Penelitian ini menyimpulkan bahwa peningkatan evaluasi, sosialisasi, pelatihan, fasilitas operasional, dan pengawasan secara menyeluruh sangat diperlukan guna mengoptimalkan pengelolaan linen serta menekan risiko infeksi nosokomial. Kata Kunci: Pengelolaan Linen, Infeksi Nosokomial, Mutu Pelayanan
Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 Afladhanti, Putri Mahirah; Romadhan, Muhammad Despriansyah; Hamzah, Haidar Ali; Putri, Safa Nabila; Angelica, Ellen Callista
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8399

Abstract

COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2. This study aims to identify the potential compounds derived from Ginkgo biloba as potential SARS-CoV-2 inhibitors using a molecular docking study. A total of twenty-one compounds of Ginkgo biloba and comparative drugs were used in this study. The materials were downloaded from rcsb for protein targets and pubchem for comparative drugs and compounds. In this study, Lipinski rule of five using Swiss ADME web tool was used. Moreover, toxicity analysis using admetSAR 2.0 online test also used to predict toxicological profile of compounds. Dockings were carried out on Mpro, TMPRSS2, RdRp, and ACE2 protein targets by AutodockTools 1.5.6 and Autodock Vina. The visualization of molecular interaction was carried out by Discovery Studio v16. Nine compounds met the criteria as drug-like components and were safe. Docking results showed that ginkgolide-C and bilobetin showed strong molecular interactions to all protein targets compared to the comparative drugs and other compounds. In RdRp, ginkgolide-C showed the highest binding energy with -12.7 kcal/mol. Moreover, in TMPRSS2, ACE2 and Mpro, bilobetin also showed the highest binding energy with -12.7, -9.7 and -10 kcal/mol, respectively. Ginkgolide-C and bilobetin have the potential to be developed as SARS-CoV-2 inhibitors. Therefore, in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.
Potensi Modifikasi Eksosom Derivat Bone Marrow Mesenchymal Stem Cell (BMMSC) dengan Rabies Viral Glycoprotein (RVG) sebagai Modalitas Mutakhir dalam Penatalaksanaan Penyakit Alzheimer Putri, Safa Nabila; Hidayatullah, Muhammad Rizky; Alfadhanti, Putri Mahirah
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 2 (2023): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i2.10443

Abstract

Pendahuluan: Penyakit Alzheimer adalah penyakit neurodegeneratif yang menyebabkan gangguan progresif pada fungsi perilaku dan kognitif. Penyakit ini merupakan jenis demensia yang paling umum terjadi dengan prevalensi yang meningkat setiap tahunnya. Patofisiologi kompleks yang dimiliki penyakit ini menyebabkan belum adanya pengobatan yang efektif untuk penyakit Alzheimer. Tinjauan literatur ini bertujuan untuk meninjau lebih lanjut mengenai potensi Rabies Viral Glycoprotein (RVG)-modified exosomes yang berasal dari Bone Marrow Mesenchymal Stem Cell (BMMSC) melalui aktivasi mikroglial otak yang dapat mereduksi Aβ sebagai terapi kuratif terkini pada penyakit Alzheimer. Metode: Literatur dicari menggunakan situs pencari seperti Google Scholar, Science Direct, ResearchGate, dan NCBI. Kriteria inklusi dan eksklusi digunakan untuk mengeliminasi literatur yang tidak berkaitan sehingga diperoleh 24 literatur. Pembahasan: BMMSC dapat meringankan neuropatologi, penurunan memori, dan defisit perilaku. Selain itu, BMMSC yang ditransplantasikan dapat menghambat kematian sel terkait Aβ dan tau. Sementara itu, terjadi peningkatan regulasi ekspresi sitokin antiinflamasi (IL-10 dan IL-4) dan penurunan regulasi sitokin proinflamasi (TNF-a dan IL-1β). Studi ini menunjukkan bahwa penggunaan BMMSC yang diturunkan dari eksosom yang dimodifikasi RVG lebih baik daripada BMMSC yang diturunkan dari eksosom saja untuk meningkatkan fungsi kognitif pada mencit APP/ PS 1. Kesimpulan: RVG-eksosom derivat BMMSC dapat menghambat kematian sel dengan mengurangi akumulasi Aβ dan tau, menyeimbangkan faktor inflamasi otak, serta meningkatkan fungsi memori dan kognitif. RVG-eksosom BMMSC berpotensi sebagai terapi mutakhir penyakit Alzheimer serta penyakit neurogeneratif lainnya. Saran: Dibutuhkan penelitian lebih lanjut terkait mekanisme molekular, dosis, dan efek samping terapi RVG-eksosom derivate BMMSC pada penyakit Alzheimer. Kata Kunci: BMMSC, Defisit Memori, Penyakit Alzheimer, Peptida Amiloid β, Sitokin Inflamasi   Introduction: Alzheimer's disease is a neurodegenerative disease that causes progressive impairment of behavioral and cognitive functions. This disease is the most common type of dementia with an increasing prevalence every year. Due to its complex pathophysiology, there is no effective treatment to date for Alzheimer’s disease. This literature review aims to further review the potential of Rabies Viral Glycoprotein (RVG)-modified exosomes from Bone Marrow Mesenchymal Stem Cells (BMMSC) through microglial activation in the brain which can reduce Aβ as the latest curative therapy in Alzheimer's disease. Method: Literature is searched using search engines such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria were used to eliminate unrelated journals so that 24 journals were obtained. Discussion: BMMSC can alleviate neuropathology, memory decline, and behavioral deficits. In addition, transplanted BMMSC could inhibit Aβ and tau-associated cell death. Meanwhile, there is an upregulation of anti-inflammatory cytokines (IL-10 and IL-4) and a downregulation of pro-inflammatory cytokines (TNF-a and IL-1β). The study showed that the use of RVG-modified exosomes derived BMMSC was better than exosomes derived BMMSC to improve cognitive function in APP/PS 1 mice. Conclusion: RVG-modified exosomes derived BMMSC can inhibit cell death by reducing Aβ and tau accumulation, balancing brain inflammatory factors, and improving memory and cognitive function. RVG-modified exosomes derived BMMSC has the potential as an advanced therapy for Alzheimer's disease and other neurogenerative diseases. Suggestion: Further research on the molecular mechanism, dosage, and side effects of RVG-modified exosomes derived BMMSC therapy in Alzheimer’s disease is needed. Keywords: Alzheimer Disease, Amyloid β Peptide, BMMSC, Inflammatory Cytokine, Memory Deficit
Etlingera elatior Compounds as Anticancer Agents of Breast Cancer Through Inhibition of Progesterone Receptor: An In Silico Study Afladhanti, Putri Mahirah; Hamzah, Haidar Ali; Romadhan, Muhammad Despriansyah; Putri, Safa Nabila; Angelica, Ellen Callista; Theodorus, Theodorus
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp94-104

Abstract

Breast cancer is the leading cause of cancer-related death in women globally. Progesterone receptor (PR) is known as the prime example of receptors amenable to targeted breast cancer drug therapy. Etlingera elatior is an herbal plant that has been renowned to have anticancer effect. This study aimed to identify the potential compounds derived from Etlingera elatior as anticancer agents of PR in breast cancer using molecular docking method. This study used fifteen compounds from Etlingera elatior along with lonaprisan as the comparative drug. The PR was downloaded from RCSB, whereas compounds and lonaprisan were from Pubchem. The drug-likeness test based on Lipinski’s rule of five was conducted using SwissADME. Toxicity analysis using admetSAR 2.0 was used to predict toxicological profile of the compounds. Compounds and lonaprisan were docked on PR using AutoDock tools 1.5.6 and AutoDock Vina 1.1.2. Molecular interactions were visualized by Discovery Studio v16. A total of nine compounds met the criteria as drugs based on drug-likeness and toxicity tests. All nine compounds except caffeic acid and vanillic acid had higher binding affinities on PR compared with lonaprisan. Ergosterol peroxide exhibited the highest binding affinity on PR with values of -9.8 kcal/mol. Moreover, ergosterol peroxide-PR interaction had thirteen hydrophobic bonds and a hydrogen bond with amino acid residues were found in the active site of PR. Most of the compounds found in Etlingera elatior have the potential to be anticancer agents of PR in breast cancer with ergosterol peroxide being the most potential compound. Further in vitro and in vivo research are needed.Keywords: breast cancer, ergosterol peroxide, Etlingera elatior, progesterone receptor, in silico.
Co-Authors Afladhanti, Putri Mahirah Alfadhanti, Putri Mahirah Aminingsih, Purwanti Angelica, Ellen Callista Ani Nuraini, Ani Hamzah, Haidar Ali Hidayatullah, Muhammad Rizky Romadhan, Muhammad Despriansyah Theodorus Theodorus