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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Ners SCRIPTA SCORE Scientific Medical Journal As-Sidanah : Jurnal Pengabdian Masyarakat Medicor : Journal of Health Informatics and Health Policy
Afladhanti, Putri Mahirah
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Religion Biochemistry, Genetics & Molecular Biology Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENINGKATAN PENGETAHUAN DETEKSI DINI KANKER PAYUDARA PADA WANITA PEKERJA PABRIK KARET DI KOTA PALEMBANG Murti, Krisna; Pariyana, Pariyana; Liberty, Iche Andriyani; Mariana, Mariana; Afladhanti, Putri Mahirah; Marylin, Dwi Tantri
As-Sidanah Vol 5 No 2 (2023): OKTOBER
Publisher : LP2M Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/assidanah.v5i2.283-293

Abstract

Breast cancer is a global and national health concern that affects women worldwide and it is responsible for causing the highest number of cancer-related deaths annually. Additionally, the high incidence of breast cancer imposes a financial burden on the nation. Early breast cancer detection in reproductive age women using breast self-examination (SADARI) was chosen due to simple, inexpensive, and non-invasive procedure. SADARI is very necessary to find out any breast abnormalities so that they can be treated early. This community service project involved providing counseling to female workers in a rubber factory at Palembang city. The counseling was delivered through a lecture and demonstration of SADARI using mannequin. A pre-and post-test questionnaire containing 30 questions was utilized as the evaluation instrument. This activity aimed to measure the increase in knowledge about breast cancer early detection with SADARI among female workers in a Palembang city rubber factory. After counseling, the mean score was 1.42 points higher than before counseling, with p-value of 0.155. The results showed non-significant increase in knowledge before and after the counseling session.
PENINGKATAN PENGETAHUAN INFEKSI MENULAR SEKSUAL DAN HIV/AIDS DENGAN PENDEKATAN CERAMAH PADA PELAJAR SMPN DI KOTA PALEMBANG Afladhanti, Putri Mahirah; Pariyana, Pariyana; Oktharina, Eka Handayani
As-Sidanah Vol 5 No 2 (2023): OKTOBER
Publisher : LP2M Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/assidanah.v5i2.342-354

Abstract

Sexually Transmitted Infections commonly abbreviated as STIs are caused by various types of microorganisms that are usually transmitted through sexual contact. Palembang is the largest contributor of STI and HIV/AIDS cases in South Sumatra. A lecture and discussion with a PowerPoint presentation and posters were used to carry out this community service project. This activity aimed to determine the increase in knowledge about STI and HIV/AIDS after health education for junior high school students in Palembang. A pre-and post-test questionnaire containing ten questions was utilized as the evaluation instrument. According to the frequency distribution of participants' knowledge before health education, 59.5% were in the category of moderate knowledge. In the meantime, after receiving health education, the participants' knowledge improved to 33.3% in the moderate category and 64.3% in the good category. Based on the mean score after health education, the value was 10.48 points greater than before health education with a p-value of 0.00. This health education about STI and HIV/AIDS can significantly improve the knowledge of participants. The most important thing in this community service was to educate students to prevent this disease, thus reducing the stigma and prevalence of these diseases.
Lasting Power Of Attorney - Provision Contemplating Help To Die West And East (Indonesia) Perspective Destra, Edwin; Firmansyah, Yohanes; Hendsun; Afladhanti, Putri Mahirah
Medicor : Journal of Health Informatics and Health Policy Vol. 1 No. 1 (2023): October 2023
Publisher : Indonesian Scientific Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61978/medicor.v1i1.61

Abstract

The enactment of legislation governing decision-making for incapacitated individuals serves a crucial purpose, primarily enabling individuals to proactively plan for future incapacity by appointing trusted agents to make decisions on their behalf. In the context of England and Wales, adults can achieve this through the utilization of a lasting power of attorney, as stipulated in the Mental Capacity Act 2005 (sections 9-14). Specifically, a health and care lasting power of attorney grants authority to an appointed agent to make day-to-day care decisions in situations where the individual is unable to do so. It is imperative for district nurses to obtain the consent of the appointed attorney before administering treatment to the donor. Furthermore, a district nurse should conduct a comprehensive review of the actions taken by the donor's attorney, involving consultation with the donor, the general practitioner (GP), and the attorney. Should conflicts regarding care persist, legal intervention by the courts may be necessary. Notably, life-sustaining or necessary therapies would continue in such instances. It is essential to emphasize that lasting health and care powers of attorney are not subject to illegality, encompassing situations where the donor expresses wishes for euthanasia or assisted dying. District nurses are required to obtain a copy of the health and care enduring power of attorney, respecting the authority of the appointed attorney to make decisions in cases where the donor lacks capacity. In the Eastern context, considerations of human rights, religion, ethics, and law collectively categorize euthanasia as a criminal act. Conversely, while Indonesia lacks specific regulations addressing euthanasia, various legal sources indicate that both seeking and performing euthanasia are deemed criminal activities.
The Potential Of Antisense Oligonucleotides (ASO) Through Inhalation Based On Gold Nanoparticle (AuNP) Delivery System In Inhibiting SARS-CoV-2 Replication And Transcription Deanasa, Raehan Satya; Afladhanti, Putri Mahirah; Syafira, Fara
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8384

Abstract

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This virus infects the respiratory, digestive, and nervous systems with a rapid transmission and a fairly high mortality rate. However, there has been no specific therapy to treat COVID-19. Previous studies have shown that antisense oligonucleotide (ASO) has good efficacy in DNA and RNA viral infections. This literature review aims to investigate the potential of inhaled ASO based on gold nanoparticles (AuNp) delivery system in inhibiting the replication and transcription of SARS-CoV-2. Literature searching using several databases, such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria are used to eliminate the journals that does not match the criteria, thus 28 journals are obtained. The results show that ASO has the potential to inhibit the replication and transcription of the SARS-CoV-2 virus through different mechanisms by binding to the target RNA and modulating the viral protein synthesis. One form of ASO modification that is often used is LNA GapmeR. LNA GapmeR stimulates viral RNA cleavage and can be administered by inhalation with nebulized ASO solution. AuNP as an ASO delivery system through inhalation can reduce toxicity and increase ASO concentrations in reaching target cells. Therefore, ASO therapy with AuNP through inhalation needs to be considered for COVID-19 treatment. Further clinical study about the ideal delivery system and optimal dosage of ASO based AuNP via inhalation for COVID-19 are needed to investigate soon.
Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 Afladhanti, Putri Mahirah; Romadhan, Muhammad Despriansyah; Hamzah, Haidar Ali; Putri, Safa Nabila; Angelica, Ellen Callista
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8399

Abstract

COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2. This study aims to identify the potential compounds derived from Ginkgo biloba as potential SARS-CoV-2 inhibitors using a molecular docking study. A total of twenty-one compounds of Ginkgo biloba and comparative drugs were used in this study. The materials were downloaded from rcsb for protein targets and pubchem for comparative drugs and compounds. In this study, Lipinski rule of five using Swiss ADME web tool was used. Moreover, toxicity analysis using admetSAR 2.0 online test also used to predict toxicological profile of compounds. Dockings were carried out on Mpro, TMPRSS2, RdRp, and ACE2 protein targets by AutodockTools 1.5.6 and Autodock Vina. The visualization of molecular interaction was carried out by Discovery Studio v16. Nine compounds met the criteria as drug-like components and were safe. Docking results showed that ginkgolide-C and bilobetin showed strong molecular interactions to all protein targets compared to the comparative drugs and other compounds. In RdRp, ginkgolide-C showed the highest binding energy with -12.7 kcal/mol. Moreover, in TMPRSS2, ACE2 and Mpro, bilobetin also showed the highest binding energy with -12.7, -9.7 and -10 kcal/mol, respectively. Ginkgolide-C and bilobetin have the potential to be developed as SARS-CoV-2 inhibitors. Therefore, in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.
Efektivitas Terapi Kombinasi Microneedling dan Vitamin C Terhadap Perbaikan Parameter Kulit Wajah Tan, Sukmawati Tansil; Yogie, Giovanno Sebastian; Destra, Edwin; Afladhanti, Putri Mahirah; Sarijuwita, Alicia; Tamaro, Anggita
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.22054

Abstract

UV rays can affect various skin physiology, including changes in skin thickness and skin color. Vitamin C acts as an antioxidant to reduce melanin and skin damage caused by the sun, but it requires a combination with other therapies to get optimal results. This research focuses on the effectiveness of microneedling with vitamin C against pigmentation and skin damage due to sun exposure. The design of this research is quasi experimental. Patients who have atrophic acne scars who meet the inclusion criteria and are treated at Sukma Cliniq Tangerang are the population in this study. The intervention in this study was microneedling with a mixture of 10% vitamin C serum to improve the skin (given when the intervention was carried out and used at home for 21 days). The intervention will be carried out on day 0 according to the procedure previously explained and measured again on day 42. The variable measurements in this study aim at the value of UV damage and skin pigmentation before and after the combination therapy. Results: There were 36 respondents who met the inclusion criteria for this study with an average age of 33.03 years and 69.4% of respondents were women. There were changes and improvements in roughness, porphyrin, and pigmentation parameters (p value <0.001), but there was no change in UV damage parameters (p value 0.500) both before and after the intervention. There were changes and improvements in roughness, porphyrin, and pigmentation parameters after microneedling and vitamin C therapy before and after 42 days of therapy. However, there are no changes and improvements to the UV damage parameters.
Etlingera elatior Compounds as Anticancer Agents of Breast Cancer Through Inhibition of Progesterone Receptor: An In Silico Study Afladhanti, Putri Mahirah; Hamzah, Haidar Ali; Romadhan, Muhammad Despriansyah; Putri, Safa Nabila; Angelica, Ellen Callista; Theodorus, Theodorus
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp94-104

Abstract

Breast cancer is the leading cause of cancer-related death in women globally. Progesterone receptor (PR) is known as the prime example of receptors amenable to targeted breast cancer drug therapy. Etlingera elatior is an herbal plant that has been renowned to have anticancer effect. This study aimed to identify the potential compounds derived from Etlingera elatior as anticancer agents of PR in breast cancer using molecular docking method. This study used fifteen compounds from Etlingera elatior along with lonaprisan as the comparative drug. The PR was downloaded from RCSB, whereas compounds and lonaprisan were from Pubchem. The drug-likeness test based on Lipinski’s rule of five was conducted using SwissADME. Toxicity analysis using admetSAR 2.0 was used to predict toxicological profile of the compounds. Compounds and lonaprisan were docked on PR using AutoDock tools 1.5.6 and AutoDock Vina 1.1.2. Molecular interactions were visualized by Discovery Studio v16. A total of nine compounds met the criteria as drugs based on drug-likeness and toxicity tests. All nine compounds except caffeic acid and vanillic acid had higher binding affinities on PR compared with lonaprisan. Ergosterol peroxide exhibited the highest binding affinity on PR with values of -9.8 kcal/mol. Moreover, ergosterol peroxide-PR interaction had thirteen hydrophobic bonds and a hydrogen bond with amino acid residues were found in the active site of PR. Most of the compounds found in Etlingera elatior have the potential to be anticancer agents of PR in breast cancer with ergosterol peroxide being the most potential compound. Further in vitro and in vivo research are needed.Keywords: breast cancer, ergosterol peroxide, Etlingera elatior, progesterone receptor, in silico.
Co-Authors Angelica, Ellen Callista Deanasa, Raehan Satya Destra, Edwin Hamzah, Haidar Ali Hendsun Iche Andriyani Liberty, Iche Andriyani Krisna Murti Mariana Mariana Marylin, Dwi Tantri Oktharina, Eka Handayani pariyana, Pariyana Putri, Safa Nabila Romadhan, Muhammad Despriansyah Sarijuwita, Alicia Syafira, Fara Tamaro, Anggita Tan, Sukmawati Tansil Theodorus Theodorus Yogie, Giovanno Sebastian Yohanes Firmansyah