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All Journal Prosiding University Research Colloquium Sinteza
Alfarizi, Muhammad Bahtiar
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Pengaruh Suhu Dan Waktu Penyimpanan Terhadap Penurunan Kadar Sirup Kering Cefadroxil Dengan Metode FTIR Alfarizi, Muhammad Bahtiar; Rahmasari, Khusna Santika; Slamet, S; Nur, Achmad Vandian
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Mahasiswa (Student Paper Presentation)
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Cefadroxil merupakan antibiotik golongan sefalosporin yang bersifat tidak stabil dan mengalami reaksi degradasi dalam larutan selama penyimpanannya karena adanya reaksi hidrolisis. Turunan 2,5-diketopiperazine merupakan senyawa hasil reaksi hidrolisis cefadroxil yang menyebabkan peningkatan efek toksisitas dan penurunan aktivitas antibakteri. Sediaan sirup kering dalam larutan sensitif terhadap suhu dan kelembapan udara sehingga dapat mempengaruhi stabilitasnya serta dapat terjadi pembentukan sedimentasi dan terjadinya caking. Penelitian ini bertujuan untuk mengetahui pengaruh suhu dan waktu penyimpanan terhadap persentase penurunan kadar sirup kering cefadroxil. Sirup kering disimpan pada suhu ruang (15-30 oC), suhu sejuk (8-15 oC) dan suhu dingin (2-8 oC) yang terhindar dari cahaya matahari dan dianalisis kadarnya pada hari ke 0, 3, 5 dan 7. Analisis kadar cefadroxil ditentukan menggunakan Fourier Transform Infra Red (FTIR). Hasil penelitian menunjukkan bahwa suhu dan waktu penyimpanan berpengaruh terhadap penurunan kadar cefadroxil, selama 7 hari penyimpanan telah terjadi penurunan kadar pada suhu ruang sebesar 7,67 %, suhu sejuk sebesar 40,16 % dan suhu dingin sebesar 51,93 %. Hasil penelitian menunjukkan bahwa sirup kering cefadroxil lebih stabil dalam penyimpanan suhu ruang dengan batas penggunaan sampai 7 hari penyimpanan.
Validasi Metode dan Penetapan Kadar Sirup Kering Cefadroxil dengan Metode FTIR-ATR Rahmasari, Khusna Santika; Alfarizi, Muhammad Bahtiar
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.19812

Abstract

Cefadroxil is a broad-spectrum bactericidal antibiotic belonging to the first group of cephalosporins produced by the fungus Cephalosporium acremonium. This study aims to validate the method and determine the concentration of cefadroxil dry syrup using FTIR-ATR. The method used is FTIR-ATR with aquabides as a solvent. Parameter Validation of the analysis method carried out includes linearity, accuracy, precision, Limit of Detection (LOD) and Limit of Quantification (LOQ). The results of the linearity test show a value of r = 0.999 which indicates linear. The accuracy obtained is 97 - 105.5%. Precision with an Relative Standard Deviation (RSD) value of 0.54%, LOD of 469.72 µg/mL and LOQ of 1423.6 µg/mL. The results of determining the levels of cefadroxil dry syrup with three samples, namely sample A 100.2%; sample B 100.5%; sample C 100.1%. Based on the research results, it can be concluded that the FTIR-ATR method is valid and the sample concentration complies with the provisions of the Indonesian Pharmacopoeia Edition VI, namely the concentration of cefadroxil in dry syrup preparations is not less than 90% and not more than 120%.
Co-Authors Achmad Vandian Nur, Achmad Vandian Khusna Santika Rahmasari S Slamet, S