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All Journal Journal of Indonesian Specialized Nutrition Unnes Journal of Public Health
Kusuma, Refani Alycia
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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A New Opportunity Related Hypercholesterolemic and the Improvement of Glucose Levels, Lipid Profiles, and Microbial Activity: Red Dragon Fruit (Hylocereus polyrhizus) Peel Yogurt and Animal Study Putriningtyas, Natalia Desy; Cahyati, Widya Hary; Kusuma, Refani Alycia; Nugraheni, Kartika; Nisa, Alfiana Ainun
Unnes Journal of Public Health Vol. 13 No. 2 (2024)
Publisher : Universitas Negeri Semarang (UNNES) in cooperation with the Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v13i2.4365

Abstract

 Hypercholesterolemia estimated to cause 2.6 million deaths and 29.7 million disability problems.The incidence of Noncommunicable diseases (NCD) such as coronary heart disease (CHD), type2 diabetes, and some types of cancer can be involved with hypercholesterolemiaed. Red dragonfruit (Hylocereus polyrhizus) peel contains total phenolic compounds, flavonoids and dietary fiber.Red dragon fruit (Hylocereus polyrhizus) peel, which was originally considered as trash can beused to produce yogurt. This study aimed to analyse the effect of red dragon fruit (Hylocereuspolyrhizus) peel yogurt on levels of fasting blood glucose, lipid profile and microbial activity inhypercholesterolemic Wistar rats. This was an experimental- research with pre and post-test control group design. A total of 25 male Wistar rats were divided into five groups randomly. Hypercholesterolemic conditions in the Wistar rats were obtained from consuming solution consisted of 1% of cholesterol powder and 0.5% of cholic acid for 14 days. Each Wistar rats received 20 g/day standard feed. The grouping were Group 1 (negative control group); Group 2 (hypercholesterolemic group); Group 3 (1.8 ml/kg b.wt/day of dragon fruit peel yogurt); Group 4 (2.7 ml/kg b.wt/day of dragon fruit peel yogurt); Group 5 (3.6 ml/kg b.wt/day of dragon fruit peel yogurt). The intervention was performed for 28 days. Blood glucose levels and lipid profiles weremeasured before and after the intervention. Blood glucose, lipid profiles and microbial activity weremeasured using GOD-PAP, automatic biochemistry analyser and pour plate method respectively.Data were analysed using paired t test and one-way ANOVA. Blood glucose, TC, LDL-C, TGlevels were decreased, and the other side HDL-C was increased significantly in the Group dragonfruit peel. There was no difference in the total number of microbes in all groups. Dragon fruit peelyogurt is effective in improving glucose levels and lipid profile of hypercholesterolemic Wistar rats. 
IRON DEFICIENCY IN EARLY LIFE AND LATER BEHAVIORAL OUTCOMES: A SYSTEMATIC REVIEW Latifah, Suci; Septiani , Seala; Kusuma, Refani Alycia; Pratiwi, Dessy
Journal of Indonesian Specialized Nutrition Vol. 3 No. 4 (2025): Journal of Indonesian Specialized Nutrition
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63953/jisn.v3i4.67

Abstract

Background: Iron deficiency during early life is the most common micronutrient deficiency worldwide and may have lasting effects on neurodevelopment and behavior. This systematic review aimed to explore the relationship between iron deficiency in infancy (0–24 months) and behavioral outcomes beyond two years of age. Methods: This study was a systematic literature review of twenty-three articles. These articles were sourced from scientific journal articles on ScienceDirect, covering studies published between 2005 and 2025. Inclusion criteria were longitudinal cohort or randomized controlled trials assessing behavioral outcomes such as attention, hyperactivity, and socio-emotional regulation. Results: Early-life iron deficiency was consistently associated with increased internalizing and externalizing behaviors, attention deficits, and symptoms of ADHD and Sluggish Cognitive Tempo persisting into adolescence. Timing and severity of deficiency influenced outcomes, with prenatal deficiency affecting recognition memory and executive function, while infant deficiency predicted behavioral dysregulation and academic difficulties. Targeted iron supplementation reduced behavioral problems, whereas excessive or non-individualized supplementation showed limited benefits. Conclusions: Iron deficiency in early life has long-term behavioral consequences. Early detection and individualized interventions are crucial for preventing neurobehavioral impairments and optimizing child development.
Co-Authors Kartika Nugraheni Latifah, Suci Natalia Desy Putriningtyas, Natalia Desy Nisa, Alfiana Ainun Pratiwi, Dessy Septiani , Seala Widya Hary Cahyati