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TR Dewi, Sisilia
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The Effectiveness of Red Ginger Extract (Zingiber Officinale Var. Rubrum) on Decreased Blood Glucose Levels in Mice (Mus Musculus) khafyah, Nur; TR Dewi, Sisilia; Jumain, Jumain
Indonesian Health Journal Vol. 2 No. 1 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i1.23

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia conditions (increased blood glucose) caused by abnormalities in insulin secretion, abnormalities in the action of insulin or perhaps both. Red Ginger (Zingiber officinale var. rubrum) contains alkaloids, flavanoids, tannins, saponins, gingerol and shagol which have blood glucose-lowering, anti-inflammatory, anticancer and antitumor effects. This study aims to determine the effectiveness of Red Ginger extract against decreasing blood glucose levels in mice (Mus musculus). This research is a type of experimental study conducted to determine the effectiveness of red ginger extract against decreasing blood glucose levels in mice. This study was conducted using alloxane as a diabetes inducer, Na CMC 1% as a negative control, glibenclamide as a positive control, extract dose 2 %, 5 % and 7 % orally for 7 days in 5 groups of test animals. The results of the study obtained 1% Na-CMC results showed a percentage decrease, namely -16.32% and -103.03%. In the group of mice given Red Ginger extract 2% showed a percentage decrease, namely 105.57% and 102.04%. The group of mice given Red Ginger extract 5% showed a percentage decrease of 105.83% and 86.84%. The group of mice given 7% Red Ginger extract showed a percentage decrease, namely 67.34% and 97.45%. The group of mice suspended by glibenclamide showed a percentage decrease of 73.05% and 66.66%. It can be concluded that the administration of Red Ginger extract has been shown to reduce blood glucose levels in aloxane-induced mice at concentrations of 2%,5% and 7% with significant values (p < 0.05) indicating a difference and obtained the most effective concentration in lowering blood glucose levels in mice (Mus musculus) is a concentration of 7%.
Effectiveness of Fig Leaf Extract (Ficus Carica L.) in Lowering Blood Glucose in Mice (Mus Musculus) Aisyah, Nur; TR Dewi, Sisilia; Jumain, Jumain
Indonesian Health Journal Vol. 2 No. 1 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i1.26

Abstract

Fig leaves (Ficus carica L.) is a plant that has antidiabetic properties, because fig leaves contain alkaloid compounds, flavonoids, tannins, polyphenols, saponins, terpenoids, and steroids. This study aims to determine the extract of fig leaves (Ficus carica L.) in lowering blood glucose in mice (Mus musculus). Extraction is carried out by maceration with 96% ethanol solvent, then evaporated using Rotavapor. This study used alloxane as a diabetes inducer, the dose of fig leaf extract tested was 5%, 10% and 15% given orally. Observations were made on day 3 and day 7. As a positive control used Glibenclamide and Na. CMC 1% w/v as a negative control. The results showed an average percent reduction in blood glucose levels for negative controls by 18.6%, for 5% extracts by 29.1%, for 10% extracts by 46.6%, for 15% extracts by 83.9% and for positive controls by 45.8%. The results of research have been obtained that the administration of Fig Leaf extract (Ficus carica L.) is proven to reduce blood glucose levels in mice (Mus musculus) induced by alloxane at concentrations of 5%, 10%, 15%. In the One-way ANOVA test, it shows a significant value (p < 0.05) showing a significant difference in each contract. It can be concluded that fig leaves can be a potential alternative treatment for diabetes mellitus with the right concentration can be an effective and natural treatment option.
Co-Authors Jumain, Jumain khafyah, Nur Nur Aisyah