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All Journal Nursing Genius Journal
Veronica, Alda Aprilia
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Health Professions Nursing Public Health

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Severe Persistent Bronchial Asthma: Literature Review Maryam Iribaram, Siti; Pratiwi, Ulfa Ayu; Arifah, Adila Nur; Aebi, Nur; Nur Azizah, Sepriani; Ayu Wulandari, Dinda; Fadillah, Khusnul; Almaida Banda, Dhija; Purnamasari, Anisa; Veronica, Alda Aprilia
Nursing Genius Journal Vol. 2 No. 1 (2025): Nursing Genius Journal Vol. 2 No. 1 Januari 2025
Publisher : PT. Nursing Genius Care

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65874/ngj/v2.i1.2025.100

Abstract

Background: Severe persistent asthma is the most complex form of asthma, characterized by symptoms that cannot be optimally controlled despite the administration of high-dose standard therapy such as inhaled corticosteroids (ICS) combined with long-acting beta-2 agonists (LABA) and/or oral corticosteroids. This type of asthma significantly impacts the patient’s quality of life, increases the frequency of exacerbations, and leads to higher healthcare costs. Purpose: To evaluate the impact of combination therapy and biological therapy approaches on key clinical outcomes such as reduction in exacerbations, improvement in quality of life, and decreased use of systemic corticosteroids. Methods: Articles were collected from the PubMed, ScienceDirect, and other peer-reviewed journal databases, with a publication range from 2021 to 2025. Results: The search yielded 10 articles that met the specified criteria and keywords. Biologic therapy has been proven effective in reducing exacerbations, improving lung function, and decreasing dependence on systemic corticosteroids. Conclusion: The importance of early intervention, accurate diagnostic approaches, and careful use of biologic therapy highlights the need for timely detection and treatment to prevent long-term damage.
Severe Persistent Bronchial Asthma: Literature Review Iribaram, Siti Maryam; Banda, Dhija Almaida; Veronica, Alda Aprilia; Azizah, Sepriani Nur; Wulandari, Dinda Ayu; Fadilah, Khusnul; Aebi, Nur; Arifa, Adila Nur; Pratiwi, Ulfa Ayu; Purnamasari, Anisa
Nursing Genius Journal Vol. 2 No. 1 (2025): Nursing Genius Journal Vol. 2 No. 1 January 2025
Publisher : PT. Nursing Genius Care

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65874/ngj/v2.i1.2025.100

Abstract

Background: Severe persistent asthma is the most complex form of asthma, characterized by symptoms that cannot be optimally controlled despite the administration of high-dose standard therapy such as inhaled corticosteroids (ICS) combined with long-acting beta-2 agonists (LABA) and/or oral corticosteroids. This type of asthma significantly impacts the patient’s quality of life, increases the frequency of exacerbations, and leads to higher healthcare costs. Purpose: To evaluate the impact of combination therapy and biological therapy approaches on key clinical outcomes such as reduction in exacerbations, improvement in quality of life, and decreased use of systemic corticosteroids. Methods: Articles were collected from the PubMed, ScienceDirect, and other peer-reviewed journal databases, with a publication range from 2021 to 2025. Results: The search yielded 10 articles that met the specified criteria and keywords. Biologic therapy has been proven effective in reducing exacerbations, improving lung function, and decreasing dependence on systemic corticosteroids. Conclusion: The importance of early intervention, accurate diagnostic approaches, and careful use of biologic therapy highlights the need for timely detection and treatment to prevent long-term damage.
Co-Authors Aebi, Nur Almaida Banda, Dhija Anisa Purnamasari Arifa, Adila Nur Arifah, Adila Nur Ayu Wulandari, Dinda Azizah, Sepriani Nur Banda, Dhija Almaida Fadilah, Khusnul Fadillah, Khusnul Iribaram, Siti Maryam Maryam Iribaram, Siti Nur Azizah, Sepriani Pratiwi, Ulfa Ayu Purnamasari, Anisa Wulandari, Dinda Ayu